The role of TRAF6 in signal transduction and the immune response

Innate Immune Recognition

2002 • 8,157 citations

Immunobiology of Dendritic Cells

2000 • 6,653 citations

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

1999 • 3,340 citations

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

2003 • 3,104 citations

Mouse and human dendritic cell subtypes

2002 • 2,311 citations

Unresponsiveness of MyD88-Deficient Mice to Endotoxin

1999 • 2,088 citations

Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

1998 • 2,047 citations

RANK is essential for osteoclast and lymph node development

1999 • 1,417 citations

TRAF6 is a signal transducer for interleukin-1

1996 • 1,287 citations

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

1999 • 1,267 citations

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

2001 • 1,231 citations

Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling

2002 • 1,228 citations

A Toll-like Receptor That Prevents Infection by Uropathogenic Bacteria

2004 • 1,013 citations

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

2002 • 985 citations

TIRAP: an adapter molecule in the Toll signaling pathway

2001 • 962 citations

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

2002 • 803 citations

Toll/IL-1 Receptor Domain-Containing Adaptor Inducing IFN-β (TRIF) Associates with TNF Receptor-Associated Factor 6 and TANK-Binding Kinase 1, and Activates Two Distinct Transcription Factors, NF-κB and IFN-Regulatory Factor-3, in the Toll-Like Receptor Signaling

2003 • 692 citations

Distinct molecular mechanism for initiating TRAF6 signalling

2002 • 642 citations

Severe osteopetrosis, defective interleukin‐1 signalling and lymph node organogenesis in TRAF6‐deficient mice

1999 • 639 citations

Tumor necrosis factor receptor-associated factors (TRAFs)—a family of adapter proteins that regulates life and death

1998 • 597 citations

All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction

2002 • 594 citations

Mammalian Toll-like receptors

2003 • 589 citations

Endotoxin-Induced Maturation of MyD88-Deficient Dendritic Cells

2001 • 505 citations

Identification of TRAF6, a Novel Tumor Necrosis Factor Receptor-associated Factor Protein That Mediates Signaling from an Amino-terminal Domain of the CD40 Cytoplasmic Region

1996 • 484 citations

Dendritic Cell Development and Survival Require Distinct NF-κB Subunits

2002 • 395 citations

Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice

2001 • 376 citations

TRAF6 Is a Critical Factor for Dendritic Cell Maturation and Development

2003 • 269 citations

TRAF6 -deficient mice display hypohidrotic ectodermal dysplasia

2002 • 177 citations

TRAF7 Potentiates MEKK3-induced AP1 and CHOP Activation and Induces Apoptosis

2004 • 168 citations

The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells

2002 • 147 citations

Characterization of the Roles of TNF Receptor-Associated Factor 6 in CD40-Mediated B Lymphocyte Effector Functions

2000 • 91 citations

Tumor Necrosis Factor Receptor-Associated Factor 6 (TRAF6) Deficiency Results in Exencephaly and Is Required for Apoptosis within the Developing CNS

2000 • 86 citations