Circuitry of nuclear factor κB signaling

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

2003 • 3,104 citations

Towards a proteome-scale map of the human protein–protein interaction network

2005 • 2,923 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation

2002 • 1,805 citations

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

2004 • 1,759 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor

1988 • 1,200 citations

Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300

1998 • 1,200 citations

Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression

2004 • 1,170 citations

Constitutive Nuclear Factor κB Activity Is Required for Survival of Activated B Cell–like Diffuse Large B Cell Lymphoma Cells

2001 • 1,035 citations

A physical and functional map of the human TNF-α/NF-κB signal transduction pathway

2004 • 993 citations

The inhibitors of apoptosis (IAPs) and their emerging role in cancer

1998 • 985 citations

IKK-γ is an essential regulatory subunit of the IκB kinase complex

1998 • 950 citations

The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

2002 • 891 citations

Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal

1990 • 870 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

NF-κB Signals Induce the Expression of c-FLIP

2001 • 799 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

NF-κB Function in Growth Control: Regulation of Cyclin D1 Expression and G₀/G₁-to-S-Phase Transition

1999 • 777 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling

2001 • 725 citations

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.

1994 • 723 citations

Ordered Recruitment of Chromatin Modifying and General Transcription Factors to the IFN-β Promoter

2000 • 716 citations

BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells

2002 • 674 citations

Molecular Determinants of Crosstalk between Nuclear Receptors and Toll-like Receptors

2005 • 634 citations

Deciphering the Transcriptional Histone Acetylation Code for a Human Gene

2002 • 631 citations

Ferritin Heavy Chain Upregulation by NF-κB Inhibits TNFα-Induced Apoptosis by Suppressing Reactive Oxygen Species

2004 • 625 citations

IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation

2005 • 624 citations

Achieving Stability of Lipopolysaccharide-Induced NF-κB Activation

2005 • 595 citations

A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB.

1989 • 517 citations

Stimulus Specificity of Gene Expression Programs Determined by Temporal Control of IKK Activity

2005 • 504 citations

Allosteric effects of DNA on transcriptional regulators

1998 • 488 citations

Purified human IκB can rapidly dissociate the complex of the NF-κB transcription factor with its cognate DNA

1990 • 445 citations

Transcriptional Activation by NF-κB Requires Multiple Coactivators

1999 • 433 citations

NF-κB RelA Phosphorylation Regulates RelA Acetylation

2005 • 432 citations

The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers.

1993 • 416 citations

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

1999 • 410 citations

One Nucleotide in a κB Site Can Determine Cofactor Specificity for NF-κB Dimers

2004 • 383 citations

Two Pathways to NF-κB

2002 • 383 citations

The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms.

1993 • 361 citations

Activation of IKKα target genes depends on recognition of specific κB binding sites by RelB:p52 dimers

2004 • 336 citations

Genetic analysis of NF- B/Rel transcription factors defines functional specificities

2003 • 326 citations

Genetic approaches in mice to understand Rel/NF-κB and IκB function: transgenics and knockouts

1999 • 322 citations

Signaling Pathways and Genes that Inhibit Pathogen-Induced Macrophage Apoptosis— CREB and NF-κB as Key Regulators

2005 • 309 citations

Regulation of the transcriptional activity of the nuclear factor-κB p65 subunit

2002 • 305 citations

Limiting inflammatory responses during activation of innate immunity

2005 • 304 citations

Distribution of NF-κB-binding sites across human chromosome 22

2003 • 302 citations

A Comprehensive Analysis of Cytokine-induced and Nuclear Factor-κB-dependent Genes in Primary Rat Pancreatic β-Cells

2001 • 302 citations

Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages

2000 • 301 citations

Mathematical model of NF-κB regulatory module

2004 • 288 citations

Control of lymphocyte development by nuclear factor-κB

2005 • 271 citations

Essential role of IRF-3 in lipopolysaccharide-induced interferon-β gene expression and endotoxin shock

2003 • 266 citations

Identification of Direct Genomic Targets Downstream of the Nuclear Factor-κB Transcription Factor Mediating Tumor Necrosis Factor Signaling

2005 • 230 citations

Differential dependence of CD4 ⁺ CD25 ⁺ regulatory and natural killer-like T cells on signals leading to NF-κB activation

2004 • 228 citations

Transient and Selective NF-κB p65 Serine 536 Phosphorylation Induced by T Cell Costimulation Is Mediated by IκB Kinase β and Controls the Kinetics of p65 Nuclear Import

2004 • 224 citations

IKKα, IKKβ, and NEMO/IKKγ Are Each Required for the NF-κB-mediated Inflammatory Response Program

2002 • 220 citations

IκBε provides negative feedback to control NF-κB oscillations, signaling dynamics, and inflammatory gene expression

2006 • 220 citations

The glucocorticoid receptor blocks P-TEFb recruitment by NFκB to effect promoter-specific transcriptional repression

2005 • 214 citations

RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF

2002 • 213 citations

Regulation of secondary lymphoid organ development by the nuclear factor‐κB signal transduction pathway

2003 • 204 citations

Failure of Lymphopoiesis after Adoptive Transfer of NF-κB–Deficient Fetal Liver Cells

1997 • 193 citations

Lymphotoxin ॆ Receptor Induces Sequential Activation of Distinct NF-κB Factors via Separate Signaling Pathways

2003 • 171 citations

Differential Requirement for Rel/Nuclear Factor κB Family Members in Natural Killer T Cell Development

2003 • 158 citations

Novel NEMO/IκB Kinase and NF-κB Target Genes at the Pre-B to Immature B Cell Transition

2001 • 154 citations

Cytoplasmic Sequestration of Rel Proteins by IκBα Requires CRM1-Dependent Nuclear Export

2000 • 151 citations

Distinct roles of IκB proteins in regulating constitutive NF-κB activity

2005 • 150 citations

Identification of NF-κB-Dependent Gene Networks in Respiratory Syncytial Virus-Infected Cells

2002 • 135 citations

Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-κB activation pathways

2004 • 130 citations

Lymphotoxin and lipopolysaccharide induce NF‐κB‐p52 generation by a co‐translational mechanism

2003 • 127 citations

A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation

2005 • 121 citations

c-Rel Is Required for Chromatin Remodeling Across the IL-2 Gene Promoter

2003 • 120 citations

The combined absence of NF-κB1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells

2002 • 110 citations

Gene Expression Profiling of Diffuse Large B-Cell Lymphoma

2003 • 106 citations

Requirement for the NF-κB Family Member RelA in the Development of Secondary Lymphoid Organs

2002 • 105 citations

Biophysical characterization of the free IκBα ankyrin repeat domain in solution

2004 • 105 citations

Molecular mechanism for activation and regulation of matrix metalloproteinases during bacterial infections and respiratory inflammation

2004 • 100 citations

Coordination between NF-κB family members p50 and p52 is essential for mediating LTβR signals in the development and organization of secondary lymphoid tissues

2005 • 100 citations

Phorbol-ester-induced Activation of the NF- B Transcription Factor Involves Dissociation of an Apparently Cytoplasmic NF- B/Inhibitor Complex

1988 • 94 citations

Human endothelial cell response to gram-negative lipopolysaccharide assessed with cDNA microarrays

2001 • 89 citations

Comment on "Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression"

2005 • 85 citations

The κB DNA Sequence from the HIV Long Terminal Repeat Functions as an Allosteric Regulator of HIV Transcription

2002 • 85 citations

Effect of interleukin-1β and tumor necrosis factor-α on gene expression in human endothelial cells

2003 • 71 citations

The role of Rel/NF-κB transcription factors in B lymphocyte survival

2003 • 59 citations

The p65 subunit of NF-kappa B is redundant with p50 during B cell proliferative responses, and is required for germline CH transcription and class switching to IgG3.

1999 • 58 citations

Characterization of the Nuclear Import and Export Functions of IκBε

2002 • 57 citations

NF-κB RelB Forms an Intertwined Homodimer

2005 • 44 citations

The p65 Subunit of NF-κB Is Redundant with p50 During B Cell Proliferative Responses, and Is Required for Germline CH Transcription and Class Switching to IgG3

1999 • 42 citations

Use of an array technology for profiling and comparing transcription factors activated by TNFα and PMA in HeLa cells

2003 • 19 citations