TGF-? receptor function in the endothelium

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Smad-dependent and Smad-independent pathways in TGF-β family signalling

2003 • 5,052 citations

Role of Transforming Growth Factor β in Human Disease

2000 • 2,405 citations

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

1994 • 1,452 citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

1997 • 1,404 citations

Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation

2000 • 1,299 citations

New insights into TGF-β–Smad signalling

2004 • 1,169 citations

Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2

1996 • 1,089 citations

Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors

2002 • 1,088 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

1995 • 1,020 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Defective Angiogenesis in Mice Lacking Endoglin

1999 • 851 citations

Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.

1992 • 837 citations

Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis

2000 • 823 citations

PDGF, TGF-β, and Heterotypic Cell–Cell Interactions Mediate Endothelial Cell–induced Recruitment of 10T1/2 Cells and Their Differentiation to a Smooth Muscle Fate

1998 • 789 citations

Physiological Actions and Clinical Applications of Transforming Growth Factor-β (TGF-β)

1993 • 755 citations

The two faces of transforming growth factor β in carcinogenesis

2003 • 740 citations

A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 ( SMAD4)

2004 • 717 citations

Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity

1997 • 715 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

The serpin PAI-1 inhibits cell migration by blocking integrin αvβ3 binding to vitronectin

1996 • 680 citations

Activin Receptor-like Kinase (ALK)1 Is an Antagonistic Mediator of Lateral TGFβ/ALK5 Signaling

2003 • 657 citations

TGF-β Receptor Type II Deficiency Results in Defects of Yolk Sac Hematopoiesis and Vasculogenesis

1996 • 651 citations

Endoglin promotes endothelial cell proliferation and TGF-β/ALK1 signal transduction

2004 • 622 citations

Endoglin Is an Accessory Protein That Interacts with the Signaling Receptor Complex of Multiple Members of the Transforming Growth Factor-β Superfamily

1999 • 562 citations

Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice

2001 • 549 citations

CD105 is important for angiogenesis: evidence and potential applications

2003 • 545 citations

A murine model of hereditary hemorrhagic telangiectasia

1999 • 472 citations

TβRI Phosphorylation of Smad2 on Ser465 and Ser467 Is Required for Smad2-Smad4 Complex Formation and Signaling

1997 • 470 citations

Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects

1999 • 436 citations

Endoglin, an Ancillary TGFβ Receptor, Is Required for Extraembryonic Angiogenesis and Plays a Key Role in Heart Development

2000 • 433 citations

Transforming Growth Factor-β–induced Mobilization of Actin Cytoskeleton Requires Signaling by Small GTPases Cdc42 and RhoA

2002 • 405 citations

Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5

1999 • 394 citations

Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation

2001 • 383 citations

Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival

2003 • 369 citations

Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice.

2000 • 364 citations

Disruption ofacvrl1increases endothelial cell number in zebrafish cranial vessels

2002 • 364 citations

Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to three TGF-beta isoforms

1990 • 342 citations

Controlling the Angiogenic Switch

2003 • 329 citations

Vascular MAD s: Two novel MAD -related genes selectively inducible by flow in human vascular endothelium

1997 • 325 citations

Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta.

1994 • 324 citations

Endoglin Expression Is Regulated by Transcriptional Cooperation between the Hypoxia and Transforming Growth Factor-β Pathways

2002 • 320 citations

Endoglin modulates cellular responses to TGF-beta 1.

1996 • 306 citations

Double-Outlet Right Ventricle and Overriding Tricuspid Valve Reflect Disturbances of Looping, Myocardialization, Endocardial Cushion Differentiation, and Apoptosis in TGF-β ₂ –Knockout Mice

2001 • 302 citations

GADD34–PP1c recruited by Smad7 dephosphorylates TGFβ type I receptor

2004 • 252 citations

Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels

2003 • 243 citations

ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling

2003 • 241 citations

The Activin Receptor-Like Kinase 1 Gene: Genomic Structure and Mutations in Hereditary Hemorrhagic Telangiectasia Type 2

1997 • 241 citations

CD105 antagonizes the inhibitory signaling of transforming growth factor βl on human vascular endothelial cells

2000 • 232 citations

Heart and Liver Defects and Reduced Transforming Growth Factor β2 Sensitivity in Transforming Growth Factor β Type III Receptor-Deficient Embryos

2003 • 229 citations

Role of Endoglin in Cellular Responses to Transforming Growth Factor-β

1998 • 223 citations

Extracellular and Cytoplasmic Domains of Endoglin Interact with the Transforming Growth Factor-β Receptors I and II

2002 • 218 citations

Targets of transcriptional regulation by two distinct type I receptors for transforming growth factor‐β in human umbilical vein endothelial cells

2002 • 209 citations

Activin receptor–like kinase 1 is implicated in the maturation phase of angiogenesis

2002 • 201 citations

Elevated expression of endoglin, a component of the TGF-?-receptor complex, correlates with proliferation of tumor endothelial cells

1999 • 198 citations

Smurf1 Regulates the Inhibitory Activity of Smad7 by Targeting Smad7 to the Plasma Membrane

2002 • 195 citations

Transforming Growth Factor β1 (TGF-β1) Promotes Endothelial Cell Survival during In Vitro Angiogenesis via an Autocrine Mechanism Implicating TGF-α Signaling

2001 • 192 citations

Targeted Mutagenesis of Smad1 Reveals an Essential Role in Chorioallantoic Fusion

2001 • 181 citations

Extracellular Signal-regulated Kinase and the Small GTP-binding Protein, Rac, Contribute to the Effects of Transforming Growth Factor-β1 on Gene Expression

1996 • 181 citations

Receptors for Transforming Growth Factor-β

1993 • 181 citations

Endoglin regulates nitric oxide‐dependent vasodilatation

2004 • 178 citations

Inhibition of Angiogenesis in Vivo by Plasminogen Activator Inhibitor-1

2001 • 177 citations

CD105 prevents apoptosis in hypoxic endothelial cells

2003 • 170 citations

TGF-β receptor kinase inhibitor enhances growth and integrity of embryonic stem cell–derived endothelial cells

2003 • 169 citations

Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells

2002 • 165 citations

Endoglin Regulates Cytoskeletal Organization through Binding to ZRP-1, a Member of the Lim Family of Proteins

2004 • 159 citations

Complementation between kinase-defective and activation-defective TGF-beta receptors reveals a novel form of receptor cooperativity essential for signaling.

1996 • 158 citations

Defective paracrine signalling by TGFβ in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia

2004 • 157 citations

Mutant endoglin in hereditary hemorrhagic telangiectasia type 1 is transiently expressed intracellularly and is not a dominant negative.

1997 • 154 citations

Vascular cells respond differentially to transforming growth factors beta 1 and beta 2 in vitro.

1991 • 137 citations

Analysis of ALK-1 and endoglin in newborns from families with hereditary hemorrhagic telangiectasia type 2

2000 • 132 citations

Expression of Transforming Growth Factor Type III Receptor in Vascular Endothelial Cells Increases Their Responsiveness to Transforming Growth Factor β2

1995 • 128 citations

Endoglin Controls Cell Migration and Composition of Focal Adhesions

2004 • 123 citations

Signaling by chimeric erythropoietin-TGF-beta receptors: homodimerization of the cytoplasmic domain of the type I TGF-beta receptor and heterodimerization with the type II receptor are both required for intracellular signal transduction.

1996 • 120 citations

Endoglin-deficient Mice, a Unique Model to Study Hereditary Hemorrhagic Telangiectasia

2000 • 118 citations

Mouse Model for Hereditary Hemorrhagic Telangiectasia Has a Generalized Vascular Abnormality

2003 • 117 citations

Expression Analysis of Four Endoglin Missense Mutations Suggests That Haploinsufficiency Is the Predominant Mechanism for Hereditary Hemorrhagic Telangiectasia Type 1

1999 • 117 citations

Hepatic vascular malformations in hereditary hemorrhagic telangiectasia: Doppler sonographic screening in a large family

1997 • 108 citations

Vascular Endothelial Growth Factor Induces Abnormal Microvasculature in the Endoglin Heterozygous Mouse Brain

2004 • 100 citations

A hereditary haemorrhagic telangiectasia family with pulmonary involvement is unlinked to the known HHT genes, endoglin and ALK-1

2000 • 96 citations

Analysis of several endoglin mutants reveals no endogenous mature or secreted protein capable of interfering with normal endoglin function

2001 • 89 citations

Hereditary haemorrhagic telangiectasia with extensive liver involvement is not caused by either HHT1 or HHT2.

1996 • 88 citations

p38 MAPK activation by TGF-β1 increases MLC phosphorylation and endothelial monolayer permeability

2002 • 77 citations

Synergy between anti‐endoglin (CD105) monoclonal antibodies and TGF‐β in suppression of growth of human endothelial cells

2003 • 61 citations

Expression of the TGF-β coreceptor endoglin in epidermal keratinocytes and its dual role in multistage mouse skin carcinogenesis

2003 • 60 citations

Biochemical characterization of the 44G4 antigen from the HOON pre-B leukemic cell line.

1988 • 56 citations

CD105 inhibits transforming growth factor-beta-Smad3 signalling.

2004 • 55 citations

Endoglin Expression Regulates Basal and TGF-β1-induced Extracellular Matrix Synthesis in Cultured L<sub>6</sub>E<sub>9</sub> Myoblasts

2004 • 47 citations

Mutation Analysis in Spanish Patients with Hereditary Hemorrhagic Telangiectasia: Deficient Endoglin Up-regulation in Activated Monocytes

2004 • 46 citations

TNF alpha down-regulates CD105 expression in vascular endothelial cells: a comparative study with TGF beta 1.

2003 • 45 citations

Isolation of a Regulatory Region of Activin Receptor-Like Kinase 1 Gene Sufficient for Arterial Endothelium-Specific Expression

2004 • 41 citations

Supermodels and disease: insights from the HHT mice

1999 • 17 citations