Endoglin, an Ancillary TGFβ Receptor, Is Required for Extraembryonic Angiogenesis and Plays a Key Role in Heart Development

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Simplified mammalian DNA isolation procedure

1991 • 1,508 citations

Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

1994 • 1,452 citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

1997 • 1,404 citations

Blood Vessel Formation: What Is Its Molecular Basis?

1996 • 1,242 citations

Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2

1996 • 1,089 citations

Hereditary Hemorrhagic Telangiectasia

1995 • 1,052 citations

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

1995 • 1,027 citations

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

1995 • 1,020 citations

Transforming growth factor–β3 is required for secondary palate fusion

1995 • 895 citations

Betaglycan presents ligand to the TGFβ signaling receptor

1993 • 887 citations

Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.

1992 • 837 citations

Role of transforming growth factor-beta in the development of the mouse embryo.

1987 • 760 citations

Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity

1997 • 715 citations

Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-β receptor system

1991 • 661 citations

TGF-β Receptor Type II Deficiency Results in Defects of Yolk Sac Hematopoiesis and Vasculogenesis

1996 • 651 citations

Endoglin Is an Accessory Protein That Interacts with the Signaling Receptor Complex of Multiple Members of the Transforming Growth Factor-β Superfamily

1999 • 562 citations

Maternal Rescue of Transforming Growth Factor-β 1 Null Mice

1994 • 494 citations

Requirement of Type III TGF-β Receptor for Endocardial Cell Transformation in the Heart

1999 • 376 citations

Endoglin modulates cellular responses to TGF-beta 1.

1996 • 306 citations

Mouse embryonic hematopoiesis

1995 • 266 citations

Role of Endoglin in Cellular Responses to Transforming Growth Factor-β

1998 • 223 citations

Tissue Distribution and Regulation of Murine von Willebrand Factor Gene Expression In Vivo

1998 • 212 citations

Angioblast differentiation and morphogenesis of the vascular endothelium in the mouse embryo

1991 • 181 citations

Mapping of a major genetic modifier of embryonic lethality in TGFβ1 knockout mice

1997 • 166 citations

Characterization of Endoglin and Identification of Novel Mutations in Hereditary Hemorrhagic Telangiectasia

1997 • 166 citations

Mutant endoglin in hereditary hemorrhagic telangiectasia type 1 is transiently expressed intracellularly and is not a dominant negative.

1997 • 154 citations

Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor-beta binding protein of endothelial and stromal cells.

1994 • 133 citations

Antibodies to the Type II TGFβ Receptor Block Cell Activation and Migration during Atrioventricular Cushion Transformation in the Heart

1996 • 126 citations

Expression of ALK-1, a type 1 serine/threonine kinase receptor, coincides with sites of vasculogenesis and angiogenesis in early mouse development

1997 • 121 citations

Six novel mutations in the endoglin gene in hereditary hemorrhagic telangiectasia type 1 suggest a dominant-negative effect of receptor function

1995 • 109 citations

Differential expression of endoglin on fetal and adult hematopoietic cells in human bone marrow.

1995 • 102 citations

Mutation and expression analysis of the endoglin gene in hereditary hemorrhagic telangiectasia reveals null alleles

1998 • 98 citations

Cloning and expression of a cDNA encoding mouse endoglin, an endothelial cell TGF-β ligand

1994 • 88 citations

Expression of Endoglin mRNA and Protein in Human Vascular Smooth Muscle Cells

1998 • 86 citations

Distribution of endoglin in early human development reveals high levels on endocardial cushion tissue mesenchyme during valve formation

1998 • 62 citations

Type I receptor serine-threonine kinase preferentially expressed in pulmonary blood vessels

1996 • 56 citations

A Constitutive Mutation ofALK5Disrupts Cardiac Looping and Morphogenesis in Mice

1998 • 39 citations

Production of the transforming growth factor-β binding protein endoglin is regulated during chick heart development

1998 • 23 citations