Supermodels and disease: insights from the HHT mice

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

1994 • 1,452 citations

Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2

1996 • 1,089 citations

Hereditary Hemorrhagic Telangiectasia

1995 • 1,052 citations

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

1995 • 1,020 citations

Defective Angiogenesis in Mice Lacking Endoglin

1999 • 851 citations

Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity

1997 • 715 citations

TGF-β Receptor Type II Deficiency Results in Defects of Yolk Sac Hematopoiesis and Vasculogenesis

1996 • 651 citations

Age‐related clinical profile of hereditary hemorrhagic telangiectasia in an epidemiologically recruited population

1989 • 567 citations

Endoglin Is an Accessory Protein That Interacts with the Signaling Receptor Complex of Multiple Members of the Transforming Growth Factor-β Superfamily

1999 • 562 citations

A murine model of hereditary hemorrhagic telangiectasia

1999 • 472 citations

Endoglin, an Ancillary TGFβ Receptor, Is Required for Extraembryonic Angiogenesis and Plays a Key Role in Heart Development

2000 • 433 citations

Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5

1999 • 394 citations

Rare diseases bullet 4: Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations: issues in clinical management and review of pathogenic mechanisms

1999 • 365 citations

Role of Endoglin in Cellular Responses to Transforming Growth Factor-β

1998 • 223 citations

Mapping of a major genetic modifier of embryonic lethality in TGFβ1 knockout mice

1997 • 166 citations

Characterization of Endoglin and Identification of Novel Mutations in Hereditary Hemorrhagic Telangiectasia

1997 • 166 citations

Mutant endoglin in hereditary hemorrhagic telangiectasia type 1 is transiently expressed intracellularly and is not a dominant negative.

1997 • 154 citations

Assignment of Transforming Growth Factor β1 and β3 and a Third New Ligand to the Type I Receptor ALK-1

1999 • 144 citations

Morphogenesis of the First Blood Vessels

1998 • 138 citations

Hereditary haemorrhagic telangiectasia with extensive liver involvement is not caused by either HHT1 or HHT2.

1996 • 88 citations

Strain dependency of TGF?1 function during embryogenesis

1999 • 84 citations