Transforming Growth Factor β1 (TGF-β1) Promotes Endothelial Cell Survival during In Vitro Angiogenesis via an Autocrine Mechanism Implicating TGF-α Signaling

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Angiogenic Factors

1987 • 3,702 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Angiogenesis.

1992 • 2,581 citations

Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells

1998 • 2,282 citations

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

1998 • 1,963 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

PI3K: Downstream AKTion Blocks Apoptosis

1997 • 1,693 citations

Tyrosine Kinase Inhibition: An Approach to Drug Development

1995 • 1,655 citations

Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

1994 • 1,452 citations

Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and Angiogenesis

1999 • 1,291 citations

Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2

1996 • 1,089 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

1995 • 1,020 citations

Vascular Endothelial Growth Factor Induces Expression of the Antiapoptotic Proteins Bcl-2 and A1 in Vascular Endothelial Cells

1998 • 996 citations

VEGF is required for growth and survival in neonatal mice

1999 • 901 citations

Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

1986 • 856 citations

Defective Angiogenesis in Mice Lacking Endoglin

1999 • 851 citations

Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis

2000 • 823 citations

Role of transforming growth factor-beta in the development of the mouse embryo.

1987 • 760 citations

TGF-β induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop

1990 • 756 citations

The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand‐receptor interactions

1997 • 719 citations

Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells.

1994 • 702 citations

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

1997 • 699 citations

Integrin signaling and cell growth control

1998 • 655 citations

TGF-β Receptor Type II Deficiency Results in Defects of Yolk Sac Hematopoiesis and Vasculogenesis

1996 • 651 citations

Differentiation of endothelium

1995 • 617 citations

In vitro rapid organization of endothelial cells into capillary-like networks is promoted by collagen matrices.

1983 • 616 citations

Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix.

1988 • 571 citations

Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects

1995 • 553 citations

Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor beta: a proposed model for indirect mitogenesis involving autocrine activity.

1986 • 541 citations

Vascular development: cellular and molecular regulation

1997 • 532 citations

The TGF-α precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction

1989 • 482 citations

Molecular mechanisms of blood vessel formation

1997 • 480 citations

Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane.

1990 • 470 citations

Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways

1997 • 470 citations

Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro.

1990 • 466 citations

Inhibition of Endothelial Regeneration by Type-Beta Transforming Growth Factor from Platelets

1986 • 439 citations

Arteriovenous malformations in mice lacking activin receptor-like kinase-1

2000 • 438 citations

Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects

1999 • 436 citations

Transmembrane TGF-α precursors activate EGF/TGF-α receptors

1989 • 432 citations

Integrin αvβ3 Requirement for Sustained Mitogen-activated Protein Kinase Activity during Angiogenesis

1998 • 397 citations

Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5

1999 • 394 citations

Signaling inputs converge on nuclear effectors in TGF-β signaling

2000 • 359 citations

Integrins, Oncogenes, and Anchorage Independence

1997 • 345 citations

Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta

1999 • 337 citations

Inhibitory action of transforming growth factor beta on endothelial cells.

1987 • 324 citations

Transforming growth factor-beta inhibits endothelial cell proliferation

1986 • 313 citations

Inhibition of endothelial cell proliferation by type β-transforming growth factor: Interactions with acidic and basic fibroblast growth factors

1986 • 312 citations

Endothelial apoptosis in Braf-deficient mice

1997 • 291 citations

Distinct signal transduction pathways are utilized during the tube formation and survival phases of in vitro angiogenesis

1998 • 266 citations

The Physiology Of Transforming Growth Factor-α

1992 • 257 citations

A General Strategy for Isolation of Endothelial Cells From Murine Tissues

1997 • 232 citations

Expression of transforming growth factor β2 RNA during murine embryogenesis

1989 • 202 citations

Transforming growth factor beta₁ modulates extracellular matrix organization and cell‐cell junctional complex formation during in vitro angiogenesis

1990 • 184 citations

The p42/p44 MAP Kinase Pathway Prevents Apoptosis Induced by Anchorage and Serum Removal

2000 • 179 citations

TGF-β Plays a Key Role in Morphogenesis of the Pancreatic Islets of Langerhans by Controlling the Activity of the Matrix Metalloproteinase MMP-2

1998 • 174 citations

Progressive growth in immunodeficient mice and host cell recruitment by mouse endothelial cells transformed by polyoma middle-sized T antigen: implications for the pathogenesis of opportunistic vascular tumors.

1994 • 168 citations

Transforming Growth Factor β1 Down-regulates Vascular Endothelial Growth Factor Receptor 2/flk-1 Expression in Vascular Endothelial Cells

1996 • 164 citations

Novel Regulation of Type IV Collagenase (Matrix Metalloproteinase-9 and -2) Activities by Transforming Growth Factor-β1 in Human Prostate Cancer Cell Lines

1999 • 163 citations

Modulation of transforming growth factor beta receptor levels on microvascular endothelial cells during in vitro angiogenesis.

1996 • 161 citations

p70 S6 Kinase-mediated Protein Synthesis Is a Critical Step for Vascular Endothelial Cell Proliferation

1999 • 160 citations

TGF‐β stimulates primary human skin fibroblast DNA synthesis via an autocrine production of PDGF‐related peptides

1989 • 154 citations

Complementary patterns of expression of c-ets 1, c-myb and c-myc in the blood-forming system of the chick embryo

1989 • 147 citations

VEGF deprivation-induced apoptosis is a component of programmed capillary regression

1999 • 144 citations

Effects Of Culture Conditions On The Proliferation, Morphology And Migration Of Bovine Aortic Endothelial Cells

1983 • 131 citations

An Immunological Approach Reveals Biological Differences between the Two NDF/Heregulin Receptors, ErbB-3 and ErbB-4

1996 • 130 citations

Transforming Growth Factor β1 Rescues Serum Deprivation-induced Apoptosis via the Mitogen-activated Protein Kinase (MAPK) Pathway in Macrophages

1999 • 101 citations

cAMP-mediated Growth Inhibition in Fibroblasts Is Not Mediated via Mitogen-activated Protein (MAP) Kinase (ERK) Inhibition

1996 • 95 citations

Endothelial cell integrin α5β1 expression is modulated by cytokines and during migration in vitro

1999 • 83 citations

A model system for tumor angiogenesis: Involvement of transforming growth factor-α in tube formation of human microvascular endothelial cells induced by esophageal cancer cells

1992 • 82 citations

Transforming growth factor β‐1 positively modulates the bioactivity of fibroblast growth factor on corneal endothelial cells

1989 • 73 citations

The Latent Transforming Growth Factor-β–binding Protein-1 Promotes In Vitro Differentiation of Embryonic Stem Cells into Endothelium

2000 • 73 citations

Endothelial adhesion molecules in the development of the vascular tree: the garden of forking paths

1999 • 72 citations

Evidence that Vascular Endothelial Cells Can Induce the Retraction of Fibrin Clots

1981 • 58 citations

Cyclic Adenosine 3′,5′-Monophosphate Regulates GLUT4 and GLUT1 Glucose Transporter Expression and Stimulates Transcriptional Activity of the GLUT1 Promoter in Muscle Cells*

1997 • 36 citations

Virally activated ras cooperates with integrin to induce tubulogenesis in sinusoidal endothelial cell lines

1998 • 36 citations

Regional Expression of Transforming Growth Factor-α in Rat Ventral Prostate during Postnatal Development, after Androgen Ablation, and after Androgen Replacement*

1998 • 23 citations