Signaling by chimeric erythropoietin-TGF-beta receptors: homodimerization of the cytoplasmic domain of the type I TGF-beta receptor and heterodimerization with the type II receptor are both required for intracellular signal transduction.

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

1995 • 1,020 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

Dimerization of the Extracellular Domain of the Human Growth Hormone Receptor by a Single Hormone Molecule

1991 • 879 citations

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

1993 • 779 citations

Expression cloning of the murine erythropoietin receptor

1989 • 776 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

Expression cloning and characterization of the TGF-β type III receptor

1991 • 638 citations

Rational Design of Potent Antagonists to the Human Growth Hormone Receptor

1992 • 633 citations

Activation of cell growth by binding of Friend spleen focus-forming virus gp55 glycoprotein to the erythropoietin receptor

1990 • 468 citations

Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity

1990 • 325 citations

Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta.

1994 • 324 citations

A Transforming Growth Factor β Type I Receptor that Signals to Activate Gene Expression

1994 • 296 citations

Loss of receptors for transforming growth factor beta in human T-cell malignancies.

1994 • 219 citations

Activation and inhibition of erythropoietin receptor function: role of receptor dimerization.

1994 • 201 citations

The types II and III transforming growth factor-beta receptors form homo-oligomers.

1994 • 199 citations

Dimerization of the Extracellular Domain of the Erythropoietin (EPO) Receptor by EPO: One High-Affinity and One Low-Affinity Interaction

1996 • 196 citations

Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia.

1994 • 189 citations

The transforming growth factor beta receptors types I, II, and III form hetero-oligomeric complexes in the presence of ligand.

1993 • 181 citations

Trypanosome invasion of mammalian cells requires activation of the TGFβ signaling pathway

1995 • 158 citations

Complementation between kinase-defective and activation-defective TGF-beta receptors reveals a novel form of receptor cooperativity essential for signaling.

1996 • 158 citations

Homomeric interactions between type II transforming growth factor-beta receptors.

1994 • 137 citations

The Soluble Exoplasmic Domain of the Type II Transforming Growth Factor (TGF)-β Receptor

1995 • 116 citations

Biochemical evidence for the autophosphorylation and transphosphorylation of transforming growth factor beta receptor kinases.

1995 • 116 citations

[22] Iodine monochloride (ICI) iodination techniques

1983 • 95 citations

Reconstitution and transphosphorylation of TGF-beta receptor complexes.

1994 • 81 citations

Phosphorylation-dependent Interaction of the Cytoplasmic Domains of the Type I and Type II Transforming Growth Factor-β Receptors

1995 • 80 citations

Signaling Activity of Homologous and Heterologous Transforming Growth Factor-β Receptor Kinase Complexes

1995 • 78 citations

Cooperative Binding of Transforming Growth Factor (TGF)-β2 to the Types I and II TGF-β Receptors

1995 • 73 citations

Distinct roles of the intracellular domains of transforming growth factor-beta type I and type II receptors in signal transduction.

1994 • 66 citations

GH3 Pituitary Tumor Cells Contain Heteromeric Type I and Type II Receptor Complexes for Transforming Growth Factor β and Activin-A

1995 • 64 citations

Expression of a constitutively active erythropoietin receptor in primary hematopoietic progenitors abrogates erythropoietin dependence and enhances erythroid colony-forming unit, erythroid burst-forming unit, and granulocyte/macrophage progenitor growth.

1993 • 61 citations

A single heteromeric receptor complex is sufficient to mediate biological effects of transforming growth factor-beta ligands.

1994 • 54 citations

Activation and Inhibition of Erythropoietin Receptor Function: Role of Receptor Dimerization

1994 • 53 citations

Analysis of Hornozygous TGFβ1 Null Mouse Embryos Demonstrates Defects in Yolk Sac. Vasculogenesis and Hematopoiesis

1995 • 44 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 33 citations

Distinct roles of the intracellular domains of transforming growth factor-β type I and type II receptors in signal transduction

1996 • 16 citations