Smurf1 Regulates the Inhibitory Activity of Smad7 by Targeting Smad7 to the Plasma Membrane

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation

2000 • 1,299 citations

Peptide Growth Factors and Their Receptors

1991 • 1,221 citations

Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

1986 • 1,044 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

Crystal Structure of the PTEN Tumor Suppressor

1999 • 1,011 citations

Betaglycan presents ligand to the TGFβ signaling receptor

1993 • 887 citations

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

1999 • 833 citations

Smurf1 Interacts with Transforming Growth Factor-β Type I Receptor through Smad7 and Induces Receptor Degradation

2001 • 828 citations

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

1998 • 714 citations

Smads as transcriptional co-modulators

2000 • 522 citations

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

2001 • 506 citations

Characterization of a membrane receptor for transforming growth factor-beta in normal rat kidney fibroblasts.

1984 • 477 citations

Smurf2 Is a Ubiquitin E3 Ligase Mediating Proteasome-dependent Degradation of Smad2 in Transforming Growth Factor-β Signaling

2000 • 473 citations

Substrate Targeting in the Ubiquitin System

1999 • 447 citations

TGF-β signaling by Smad proteins

2000 • 406 citations

Deadly encounter: ubiquitin meets apoptosis

2002 • 356 citations

Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation

1999 • 314 citations

TGF-β induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradation

2001 • 304 citations

Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors

1998 • 281 citations

Smad6 Is a Smad1/5-induced Smad Inhibitor

2000 • 277 citations

Regulation of Smad7 Promoter by Direct Association with Smad3 and Smad4

1999 • 249 citations

The N domain of Smad7 is essential for specific inhibition of transforming growth factor-β signaling

2001 • 221 citations

Ligand-dependent Degradation of Smad3 by a Ubiquitin Ligase Complex of ROC1 and Associated Proteins

2001 • 219 citations

Membrane Targeting by C1 and C2 Domains

2001 • 218 citations

Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions

1999 • 199 citations

The C2 Domain of the Ubiquitin Protein Ligase Nedd4 Mediates Ca2+-dependent Plasma Membrane Localization

1997 • 199 citations

Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses.

1996 • 132 citations

The DSmurf Ubiquitin-Protein Ligase Restricts BMP Signaling Spatially and Temporally during Drosophila Embryogenesis

2001 • 119 citations

Structure of the C2 domain from novel protein kinase Cϵ. A membrane binding model for Ca2+-independent C2 domains

2001 • 100 citations

Multiple WW Domains, but Not the C2 Domain, Are Required for Inhibition of the Epithelial Na+ Channel by Human Nedd4

2001 • 84 citations

Identification of Developmentally Expressed Proteins That Functionally Interact with Nedd4 Ubiquitin Ligase

2002 • 77 citations

Maitotoxin activates a nonselective cation channel and stimulates Ca2+ entry in MDCK renal epithelial cells.

1994 • 51 citations

Genetic approaches to TGFβ signaling pathways

1999 • 13 citations