Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Mechanisms of angiogenesis

1997 • 5,696 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Cellular and developmental control of O₂ homeostasis by hypoxia-inducible factor 1α

1998 • 2,392 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

1994 • 1,452 citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

1997 • 1,404 citations

Implantation and the placenta: key pieces of the development puzzle

1994 • 1,362 citations

Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2

1996 • 1,089 citations

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

1995 • 1,027 citations

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

1995 • 1,020 citations

Transforming growth factor–β3 is required for secondary palate fusion

1995 • 895 citations

The Transforming Growth Factor-βs

1991 • 882 citations

Defective Angiogenesis in Mice Lacking Endoglin

1999 • 851 citations

Peptide growth factors are multifunctional

1988 • 835 citations

Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis

2000 • 823 citations

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

1993 • 779 citations

Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta.

1987 • 736 citations

Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity

1997 • 715 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors

1993 • 656 citations

TGF-β Receptor Type II Deficiency Results in Defects of Yolk Sac Hematopoiesis and Vasculogenesis

1996 • 651 citations

Lymphoid Potential, Probed before Circulation in Mouse, Is Restricted to Caudal Intraembryonic Splanchnopleura

1996 • 591 citations

Characterization of Type I Receptors for Transforming Growth Factor-β and Activin

1994 • 558 citations

Maternal Rescue of Transforming Growth Factor-β 1 Null Mice

1994 • 494 citations

Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects

1999 • 436 citations

Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5

1999 • 394 citations

The L45 loop in type I receptors for TGF‐β family members is a critical determinant in specifying Smad isoform activation

1998 • 390 citations

Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice.

2000 • 364 citations

Inhibitory action of transforming growth factor beta on endothelial cells.

1987 • 324 citations

Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta.

1994 • 324 citations

Transforming growth factor β: a matter of life and death

1994 • 306 citations

Transforming growth factor-β: pleiotropic role in the regulation of hematopoiesis

2000 • 298 citations

Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene

1988 • 255 citations

Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins

1994 • 252 citations

Responsiveness to transforming growth factor-beta (TGF-beta) restored by genetic complementation between cells defective in TGF-beta receptors I and II

1991 • 252 citations

Transforming growth factor-β: pleiotropic role in the regulation of hematopoiesis

2000 • 232 citations

Transforming growth factor beta 1 directly and reversibly inhibits the initial cell divisions of long-term repopulating hematopoietic stem cells

1996 • 204 citations

Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse

1996 • 203 citations

Properties of the earliest clonogenic hemopoietic precursors to appear in the developing murine yolk sac.

1986 • 174 citations

Assignment of Transforming Growth Factor β1 and β3 and a Third New Ligand to the Type I Receptor ALK-1

1999 • 144 citations

Vascular cells respond differentially to transforming growth factors beta 1 and beta 2 in vitro.

1991 • 137 citations

Early embryonic vascular development

1996 • 132 citations

Large T antigens of simian virus 40 and polyomavirus efficiently establish primary fibroblasts

1986 • 131 citations

Expression of ALK-1, a type 1 serine/threonine kinase receptor, coincides with sites of vasculogenesis and angiogenesis in early mouse development

1997 • 121 citations

Transforming Growth Factor-β signalling in extraembryonic mesoderm is required for yolk sac vasculogenesis in mice

1999 • 108 citations

Transforming growth factors β

1989 • 86 citations

Expression of transforming-growth-factor (TGF)-? receptors and Smad proteins in glioblastoma cell lines with distinct responses to TGF-?1

1999 • 77 citations

Transforming growth factor‐β: A bidirectional regulator of hematopoietic cell growth

1992 • 66 citations

Transforming growth factor beta (TGF-beta), a potent inhibitor of erythropoiesis: neutralizing TGF-beta antibodies show erythropoietin as a potent stimulator of murine burst-forming unit erythroid colony formation in the absence of a burst-promoting activity

1995 • 52 citations

Restricted expression of type-II TGFβ receptor in murine embryonic development suggests a central role in tissue modeling and CNS patterning

1995 • 44 citations

A Mouse TGFβType I Receptor That Requires Type II Receptor for Ligand Binding

1994 • 34 citations

Ectopic expression of the transforming growth factor ? type II receptor disrupts mesoderm organisation during mouse gastrulation

1999 • 21 citations

Inhibition of transforming growth factor-induced cell growth in soft agar by oxidized polyamines

1984 • 15 citations

Expression of ALK‐1, a type 1 serine/threonine kinase receptor, coincides with sites of vasculogenesis and angiogenesis in early mouse development

1997 • 10 citations

Expression of transforming‐growth‐factor (TGF)‐β receptors and Smad proteins in glioblastoma cell lines with distinct responses to TGF‐β1

1999 • 1 citations