The role of p21ras in receptor tyrosine kinase signalling

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

Signal transduction via the MAP kinases: proceed at your own RSK.

1993 • 1,262 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1993 • 1,169 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

The neurofibromatosis type 1 gene encodes a protein related to GAP

1990 • 1,099 citations

The MAP kinase cascade is essential for diverse signal transduction pathways

1993 • 1,091 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 • 987 citations

The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21

1990 • 984 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

SH2 and SH3 domains: From structure to function

1992 • 977 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene

1982 • 928 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

The Cellular Functions of Small GTP-Binding Proteins

1990 • 881 citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1993 • 876 citations

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

1992 • 874 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

1990 • 834 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

1994 • 814 citations

Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2

1993 • 788 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

1985 • 738 citations

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1993 • 730 citations

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1992 • 714 citations

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

1993 • 705 citations

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

1992 • 692 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

1990 • 684 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

1993 • 667 citations

Cloning of bovine GAP and its interaction with oncogenic ras p21

1988 • 666 citations

Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1993 • 658 citations

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

1992 • 648 citations

Complex formation between RAS and RAF and other protein kinases.

1993 • 633 citations

Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src

1991 • 630 citations

The Function of GRB2 in Linking the Insulin Receptor to Ras Signaling Pathways

1993 • 629 citations

T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes

1982 • 617 citations

Binding of SH2 Domains of Phospholipase Cγ1, GAP, and Src to Activated Growth Factor Receptors

1990 • 608 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis

1992 • 583 citations

PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

1990 • 561 citations

The GTPase dynamin binds to and is activated by a subset of SH3 domains

1993 • 557 citations

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

1993 • 555 citations

Biological and biochemical properties of human rasH genes mutated at codon 61

1986 • 538 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

An Unidentified Virus which causes the Rapid Production of Tumours in Mice

1964 • 535 citations

Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain

1988 • 533 citations

The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

1990 • 529 citations

Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C.

1993 • 521 citations

Extracellular signal-regulated kinases: ERKs in progress.

1991 • 519 citations

Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor

1989 • 513 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells

1982 • 494 citations

Molecular Cloning of Two Types of GAP Complementary DNA from Human Placenta

1988 • 492 citations

The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway

1987 • 491 citations

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.

1992 • 490 citations

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1991 • 489 citations

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.

1992 • 486 citations

PDGF induction of tyrosine phosphorylation of GTPase activating protein

1989 • 478 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1994 • 477 citations

Physical Conditions at the Base of a Fast Moving Antarctic Ice Stream

1990 • 477 citations

cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells.

1994 • 473 citations

Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.

1993 • 465 citations

Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway.

1994 • 454 citations

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1993 • 451 citations

Phospholipase C-β1 is a GTPase-activating protein for Gq/11, its physiologic regulator

1992 • 430 citations

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product

1991 • 424 citations

Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

1986 • 421 citations

Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro.

1993 • 420 citations

Involvement of p21ras in activation of extracellular signal-regulated kinase 2

1992 • 403 citations

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product

1988 • 402 citations

Microinjection of the oncogene form of the human H-ras (t-24) protein results in rapid proliferation of quiescent cells

1984 • 401 citations

Somatic mutations in the neurofibromatosis 1 gene in human tumors

1992 • 399 citations

Binding of GAP to Activated PDGF Receptors

1990 • 396 citations

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

1994 • 388 citations

Increasing cAMP attenuates activation of mitogen-activated protein kinase.

1993 • 383 citations

Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein

1984 • 379 citations

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.

1993 • 377 citations

cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor.

1993 • 362 citations

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

1992 • 361 citations

Molecular cloning of cDNAs encoding the GAP-associated protein p190: Implications for a signaling pathway from ras to the nucleus

1992 • 343 citations

Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73.

1992 • 343 citations

Interaction of Shc with the ζ Chain of the T Cell Receptor Upon T Cell Activation

1993 • 343 citations

SH3 domains direct cellular localization of signaling molecules

1993 • 339 citations

Differential regulation of rasGAP and neurofibromatosis gene product activities

1991 • 338 citations

Cellular ras activity and phospholipid metabolism

1988 • 331 citations

Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1

1994 • 331 citations

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells.

1990 • 327 citations

Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells.

1994 • 326 citations

Association between GTPase activators for Rho and Ras families

1992 • 322 citations

Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo.

1992 • 317 citations

Signalling by the sevenless protein tyrosine kinase is mimicked by Rasl activation

1992 • 315 citations

Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins.

1993 • 308 citations

Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)

1990 • 305 citations

Binding of the Ras Activator Son of Sevenless to Insulin Receptor Substrate-1 Signaling Complexes

1993 • 298 citations

Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor

1991 • 298 citations

Activation of the c-Raf protein kinase by protein kinase C phosphorylation.

1992 • 288 citations

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.

1992 • 286 citations

Insulin stimulation of gene expression mediated by p21ras activation.

1991 • 284 citations

Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein.

1991 • 279 citations

Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62

1992 • 271 citations

Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity.

1992 • 268 citations

Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity.

1990 • 264 citations

The Son of sevenless Gene Product: a Putative Activator of Ras

1992 • 263 citations

Epidermal growth factor—induced actin remodeling is regulated by 5-lipoxygenase and cyclooxygenase products

1993 • 255 citations

Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro.

1993 • 251 citations

Molecular cloning and expression of the major protein kinase C substrate of platelets

1988 • 250 citations

Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva

1991 • 246 citations

ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels

1990 • 244 citations

Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells.

1990 • 242 citations

Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase.

1993 • 241 citations

Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells.

1993 • 238 citations

Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition.

1992 • 235 citations

Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator.

1992 • 234 citations

Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts.

1993 • 234 citations

Lysophosphatidic acid stimulates mitogen-activated protein kinase activation via a G-protein-coupled pathway requiring p21ras and p74raf-1.

1993 • 233 citations

A Cytosolic Protein Catalyzes the Release of GDP from p21 ^ras

1990 • 231 citations

GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit.

1992 • 228 citations

Ras p21 as a Potential Mediator of Insulin Action in Xenopus Oocytes

1987 • 224 citations

Activation of p21ras by transforming growth factor beta in epithelial cells.

1992 • 223 citations

Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells.

1994 • 218 citations

Role of IRS-1-GRB-2 complexes in insulin signaling.

1994 • 215 citations

Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex.

1993 • 209 citations

The effector interactions of p21ras

1993 • 193 citations

Differentiation factors, including nerve growth factor, fibroblast growth factor, and interleukin-6, induce an accumulation of an active Ras.GTP complex in rat pheochromocytoma PC12 cells.

1992 • 185 citations

Insulin induction of Xenopus laevis oocyte maturation is inhibited by monoclonal antibody against p21 ras proteins.

1987 • 183 citations

Ras Activation by Insulin and Epidermal Growth Factor through Enhanced Exchange of Guanine Nucleotides on p21^ras

1993 • 176 citations

Involvement of She in Insulin- and Epidermal Growth Factor-Induced Activation of p21^ras

1994 • 174 citations

Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries.

1992 • 168 citations

Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor.

1990 • 167 citations

Suppression of c-ras transformation by GTPase-activating protein

1990 • 166 citations

A dominant-negative mutant of raf blocks mitogen-activated protein kinase activation by growth factors and oncogenic p21ras.

1993 • 161 citations

Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways.

1993 • 159 citations

Gap Domains Responsible for Ras P21-Dependent Inhibition of Muscarinic Atrial K ⁺ Channel Currents

1992 • 154 citations

Role of Protein Kinase C in T-Cell Antigen Receptor Regulation of p21^ras: Evidence that Two p21^ras Regulatory Pathways Coexist in Τ Cells

1992 • 151 citations

Identification of a nucleotide exchange-promoting activity for p21ras.

1990 • 144 citations

Identification of insulin‐stimulated protein kinase‐1 as the rabbit equivalent of rsk^mo‐2

1993 • 141 citations

Erythropoietin induces p21ras activation and p120GAP tyrosine phosphorylation in human erythroleukemia cells.

1992 • 139 citations

Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression.

1991 • 138 citations

Identification of the SH3 Domain of GAP as an Essential Sequence for Ras-GAP-Mediated Signaling

1993 • 137 citations

Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction.

1993 • 135 citations

Characterization of full-length neurofibromin: tubulin inhibits Ras GAP activity.

1993 • 128 citations

Stimulation of tyrosine phosphorylation and accumulation of GTP-bound p21ras upon antibody-mediated alpha 2 beta 1 integrin activation in T-lymphoblastic cells.

1993 • 127 citations

Raf-1 is a potential substrate for mitogen-activated protein kinase in vivo

1991 • 126 citations

Microinjection of Transforming ras protein induces c-fos Expression

1987 • 123 citations

Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts.

1992 • 123 citations

Raf-1 protein kinase is important for progesterone-induced Xenopus oocyte maturation and acts downstream of mos.

1993 • 120 citations

A novel membrane factor stimulates guanine nucleotide exchange reaction of ras proteins

1990 • 119 citations

Epidermal Growth Factor Regulates the Exchange Rate of Guanine Nucleotides on p21^ras in Fibroblasts

1993 • 117 citations

Proliferative but not nonproliferative responses to granulocyte colony- stimulating factor are associated with rapid activation of the p21ras/MAP kinase signalling pathway

1994 • 113 citations

Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF.

1993 • 108 citations

Isolation of multiple mouse cDNAs with coding homology to Saccharomyces cerevisiae CDC25: identification of a region related to Bcr, Vav, Dbl and CDC24.

1992 • 106 citations

GTPase-Activating Protein SH2-SH3 Domains Induce Gene Expression in a Ras-Dependent Fashion

1992 • 101 citations

Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function.

1994 • 101 citations

Suppression of src transformation by overexpression of full-length GTPase-activating protein (GAP) or of the GAP C terminus.

1991 • 101 citations

Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types.

1993 • 100 citations

Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2

1993 • 100 citations

Regulation of Ras-GAP and the Neurofibromatosis-1 Gene Product by Eicosanoids

1991 • 100 citations

Interleukin-2-induced tyrosine phosphorylation of p52shc in T lymphocytes.

1993 • 98 citations

Inhibition of v-src-induced transformation by a GTPase-activating protein.

1991 • 94 citations

Cloning of a Grb2 Isoform with Apoptotic Properties

1994 • 91 citations

Mechanistic Aspects of Signaling Through Ras in NIH 3T3 Cells

1992 • 88 citations

Phosphorylation of the S. cerevisiae Cdc25 in response to glucose results in its dissociation from Ras

1992 • 85 citations

Interleukin 2-induced activation of Ras requires two domains of interleukin 2 receptor beta subunit, the essential region for growth stimulation and Lck-binding domain.

1992 • 83 citations

Preferential inhibition of the oncogenic form of RasH by mutations in the GAP binding/“effector” domain

1991 • 83 citations

Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein.

1994 • 78 citations

Growth factors differentially stimulate the phosphorylation of Shc proteins and their association with Grb2 in PC-12 pheochromocytoma cells.

1994 • 78 citations

Signal transduction during C. elegans vulval induction

1991 • 75 citations

Activation of Ras by insulin in 3T3 L1 cells does not involve GTPase-activating protein phosphorylation.

1992 • 73 citations

Release from G1 growth arrest by transforming growth factor beta 1 requires cellular ras activity.

1993 • 69 citations

Purification, characterization, and western blot analysis of human GTPase-activating protein from native and recombinant sources.

1990 • 69 citations

Plasma Membrane-Targeted ras GTPase-Activating Protein Is a Potent Suppressor of p21^ras Function

1993 • 67 citations

The epidermal growth factor receptor phosphorylates GTPase-activating protein (GAP) at Tyr-460, adjacent to the GAP SH2 domains.

1991 • 66 citations

Insulin activation of protein kinase C: a reassessment

1991 • 65 citations

In vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinase.

1993 • 63 citations

Relation between the insulin receptor number in cells, autophosphorylation and insulin-stimulated Ras.GTP formation.

1992 • 60 citations

CD2 antigen mediated activation of the guanine nucleotide binding proteins p21ras in human T lymphocytes.

1991 • 60 citations

Implication of GAP in Ras-Dependent Transactivation of a Polyoma Enhancer Sequence

1992 • 56 citations

Identification of SHC as a Substrate of the Insulin Receptor Kinase Distinct from the GAP-Associated 62-kDa Tyrosine Phosphoprotein

1993 • 56 citations

Interaction between the p21ras GTPase activating protein and the insulin receptor.

1992 • 46 citations

Insulin-dependent covalent reassociation of isolated alpha beta heterodimeric insulin receptors into an alpha 2 beta 2 heterotetrameric disulfide-linked complex.

1988 • 44 citations

Raf-1 Protein Kinase Is an Integral Component of the Oncogenic Signal Cascade Shared by Epidermal Growth Factor and Platelet-Derived Growth Factor

1992 • 38 citations

Critical Role of Cellular ras Proteins in Proliferative Signal Transduction

1988 • 31 citations

Functional Role of GTPase-Activating Protein in Cell Transformation by pp6O^v-src

1993 • 29 citations

Differential regulation of cellular activities by GTPase-activating protein and NF1.

1993 • 29 citations

Platelet-derived growth factor increases the turnover of GTP/GDP on ras in permeabilized fibroblasts.

1993 • 26 citations

Activated Src tyrosine kinase phosphorylates Tyr-457 of bovine GTPase-activating protein (GAP) in vitro and the corresponding residue of rat GAP in vivo.

1992 • 26 citations

Epidermal‐growth‐factor receptors generate Ras · GTP more efficiently than insulin receptors

1993 • 25 citations

Genetic definition of ras effector elements.

1991 • 19 citations

Platelet-derived growth factor-induced p21ras-mediated signaling is independent of platelet-derived growth factor receptor interaction with GTPase-activating protein or phosphatidylinositol-3-kinase.

1994 • 16 citations