GTPase-Activating Protein SH2-SH3 Domains Induce Gene Expression in a Ras-Dependent Fashion

ras GENES

1987 • 3,818 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

DNA cloning : a practical approach

1985 • 2,302 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

The Cellular Functions of Small GTP-Binding Proteins

1990 • 881 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Cloning of bovine GAP and its interaction with oncogenic ras p21

1988 • 666 citations

Binding of SH2 Domains of Phospholipase Cγ1, GAP, and Src to Activated Growth Factor Receptors

1990 • 608 citations

Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain

1988 • 533 citations

High efficiency gene transfer into mammalian cells

1984 • 498 citations

Src homology region 2 domains direct protein-protein interactions in signal transduction.

1990 • 498 citations

Molecular Cloning of Two Types of GAP Complementary DNA from Human Placenta

1988 • 492 citations

PDGF induction of tyrosine phosphorylation of GTPase activating protein

1989 • 478 citations

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product

1988 • 402 citations

Binding of GAP to Activated PDGF Receptors

1990 • 396 citations

Molecular cloning of cDNAs encoding the GAP-associated protein p190: Implications for a signaling pathway from ras to the nucleus

1992 • 343 citations

Differential regulation of rasGAP and neurofibromatosis gene product activities

1991 • 338 citations

[75] Assay of transforming activity of tumor virus DNA

1980 • 331 citations

Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo.

1992 • 317 citations

The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.

1990 • 314 citations

Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)

1990 • 305 citations

Insulin stimulation of gene expression mediated by p21ras activation.

1991 • 284 citations

Platelet-derived growth factor stimulates formation of active p21ras.GTP complex in Swiss mouse 3T3 cells.

1990 • 282 citations

Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein.

1991 • 279 citations

Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62

1992 • 271 citations

Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity.

1990 • 264 citations

ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels

1990 • 244 citations

Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells.

1990 • 242 citations

Suppression of c-ras transformation by GTPase-activating protein

1990 • 166 citations

A C-terminal domain of GAP is sufficient to stimulate ras p21 GTPase activity.

1989 • 161 citations

Gap Domains Responsible for Ras P21-Dependent Inhibition of Muscarinic Atrial K ⁺ Channel Currents

1992 • 154 citations

Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression.

1991 • 138 citations

GTPase-activating protein interactions with the viral and cellular Src kinases.

1991 • 79 citations

Protein-Tyrosine Kinases Regulate the Phosphorylation, Protein Interactions, Subcellular Distribution, and Activity of p21^rasGTPase-Activating Protein

1991 • 50 citations

Interaction between the p21ras GTPase activating protein and the insulin receptor.

1992 • 46 citations

Association of a tyrosine kinase activity with GAP complexes in v-src transformed fibroblasts.

1992 • 14 citations