Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction.

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 • 987 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1993 • 876 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1993 • 730 citations

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1992 • 714 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

Complex formation between RAS and RAF and other protein kinases.

1993 • 633 citations

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.

1992 • 490 citations

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1991 • 489 citations

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

1988 • 470 citations

Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.

1992 • 453 citations

Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

1986 • 421 citations

Involvement of p21ras in activation of extracellular signal-regulated kinase 2

1992 • 403 citations

let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein

1990 • 397 citations

Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts

1987 • 330 citations

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells.

1990 • 327 citations

Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene

1987 • 303 citations

Activation of the c-Raf protein kinase by protein kinase C phosphorylation.

1992 • 288 citations

Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells.

1990 • 242 citations

Definition of the human raf amino-terminal regulatory region by deletion mutagenesis.

1989 • 240 citations

Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases.

1992 • 202 citations

Phospholipase C-mediated hydrolysis of phosphatidlycholine is an important step in PDGF-stimulated DNA synthesis

1990 • 163 citations

Molecular Species Analysis of 1,2-Diglycerides Stimulated by α-Thrombin in Cultured Fibroblasts

1989 • 161 citations

Stimulation of Phosphatidylcholine Hydrolysis, Diacylglycerol Release, and Arachidonic Acid Production by Oncogenic Ras Is a Consequence of Protein Kinase C Activation

1989 • 136 citations

Dissociation of protein kinase C activation and sn-1,2-diacylglycerol formation. Comparison of phosphatidylinositol- and phosphatidylcholine-derived diglycerides in alpha-thrombin-stimulated fibroblasts.

1991 • 120 citations

Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase

1993 • 116 citations

Ras controls coupling of growth factor receptors and protein kinase C in the membrane to Raf-1 and B-Raf protein serine kinases in the cytosol.

1992 • 111 citations

Molecular species analysis of mitogen-stimulated 1,2-diglycerides in fibroblasts. Comparison of alpha-thrombin, epidermal growth factor, and platelet-derived growth factor.

1990 • 110 citations

Kinetic evidence of a rapid activation of phosphatidylcholine hydrolysis by Ki-ras oncogene. Possible involvement in late steps of the mitogenic cascade.

1990 • 64 citations

Methods in inositide research

1991 • 60 citations

Biochemical characterization of the inhibitory effect of CsA on cytolytic T lymphocyte effector functions.

1989 • 59 citations

Hydrolysis of Phosphatidylcholine Is Stimulated by Ras Proteins during Mitogenic Signal Transduction

1992 • 59 citations

Stimulation of phosphatidylcholine breakdown by thrombin and carbachol but not by tyrosine kinase receptor ligands in cells transfected with M1 muscarinic receptors. Rapid desensitization of phosphocholine-specific (PC) phospholipase D but sustained activity of PC-phospholipase C

1992 • 52 citations

Role of Ras in signal transduction from the nerve growth factor receptor: relationship to protein kinase C, calcium and cyclic AMP.

1992 • 41 citations

H-ras and raf-1 cooperate in transformation of NIH3T3 fibroblasts.

1993 • 37 citations

Activation of phospholipase D by α-thrombin or epidermal growth factor contributes to the formation of phosphatidic acid, but not to observed increases in 1,2-diacylglycerol

1992 • 33 citations

Phosphorylation occurs in the amino terminus of the Raf-1 protein.

1992 • 12 citations