Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Signal transduction via the MAP kinases: proceed at your own RSK.

1993 • 1,262 citations

The MAP kinase cascade is essential for diverse signal transduction pathways

1993 • 1,091 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 • 987 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product

1992 • 931 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2

1993 • 788 citations

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1992 • 714 citations

Role of Cyclic Nucleotides in Growth Control

1975 • 692 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro.

1993 • 420 citations

Microtubule‐associated‐protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells

1990 • 386 citations

Increasing cAMP attenuates activation of mitogen-activated protein kinase.

1993 • 383 citations

Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells.

1992 • 370 citations

Signal integration at the level of protein kinases, protein phosphatases and their substrates

1992 • 314 citations

The mitogen-activated protein kinase activator

1992 • 285 citations

MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase.

1992 • 256 citations

Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases.

1992 • 202 citations

Increasing the cAMP content of IM-9 cells alters the phosphorylation state and protein kinase activity of the insulin receptor.

1986 • 182 citations

Inhibition of CD3-linked phospholipase C by phorbol ester and by cAMP is associated with decreased phosphotyrosine and increased phosphoserine contents of PLC-gamma 1.

1992 • 146 citations

Phosphorylation of Xenopus mitogen-activated protein (MAP) kinase kinase by MAP kinase kinase kinase and MAP kinase.

1993 • 128 citations

Prostaglandin E1 inhibits DNA synthesis in arterial smooth muscle cells stimulated with platelet-derived growth factor

1984 • 123 citations

Phosphorylation of mitogen-activated protein kinases is involved in the epidermal growth factor and phorbol ester, but not in the thyrotropin/cAMP, thyroid mitogenic pathway.

1993 • 119 citations

Cell cycle-dependent inhibition of human vascular smooth muscle cell proliferation by prostaglandin E1

1985 • 115 citations

Phosphorylation of smg p21, a ras p21-like GTP-binding Protein, by Cyclic AMP-dependent Protein Kinase in a Cell-free System and in Response to Prostaglandin E1 in Intact Human Platelets

1989 • 110 citations

Inhibition of proliferation, but not of Ca2+ mobilization, by cyclic AMP and GMP in rabbit aortic smooth-muscle cells

1992 • 108 citations

Phosphorylation of the S. cerevisiae Cdc25 in response to glucose results in its dissociation from Ras

1992 • 85 citations

Mos Stimulates MAP Kinase in Xenopus Oocytes and Activates a MAP Kinase Kinase In Vitro

1993 • 82 citations

A protein factor for ras p21-dependent activation of mitogen-activated protein (MAP) kinase through MAP kinase kinase.

1993 • 73 citations

Induction of cyclic AMP synthesis by forskolin is followed by a reduction in the expression of c‐myc messenger RNA and inhibition of ³H‐thymidine incorporation in human fibroblasts

1989 • 72 citations

The amino acid sequence of a mammalian MAP kinase kinase.

1992 • 66 citations

Evidence for involvement of phospholipase C-γ2 in signal transduction of platelet-derived growth factor in vascular smooth-muscle cells

1993 • 56 citations

cAMP-dependent protein kinase stimulates epidermal growth factor-dependent phosphorylation of epidermal growth factor receptors.

1984 • 50 citations

Effect of cyclic AMP-dependent protein kinase on insulin receptor tyrosine kinase activity

1987 • 45 citations