Isolation of multiple mouse cDNAs with coding homology to Saccharomyces cerevisiae CDC25: identification of a region related to Bcr, Vav, Dbl and CDC24.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

The Cellular Functions of Small GTP-Binding Proteins

1990 • 881 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

1990 • 684 citations

Bcr encodes a GTPase-activating protein for p21rac

1991 • 474 citations

Two promoters of different strengths control the transcription of the mouse alpha-amylase gene Amy-1a in the parotid gland and the liver

1983 • 469 citations

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product

1991 • 424 citations

Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia

1987 • 405 citations

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

1992 • 361 citations

S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein

1990 • 333 citations

Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates

1992 • 306 citations

Regulators and Effectors of ras Proteins

1991 • 303 citations

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.

1992 • 286 citations

Vaccination against ovine cysticercosis using a defined recombinant antigen

1989 • 280 citations

A novel c-abl protein product in Philadelphia-positive acute lymphoblastic leukaemia

1987 • 278 citations

Molecular characterization of two myosin heavy chain genes expressed in the adult heart

1982 • 277 citations

The BCR gene encodes a novel serine/threonine kinase activity within a single exon

1991 • 273 citations

Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator.

1992 • 234 citations

A Cytosolic Protein Catalyzes the Release of GDP from p21 ^ras

1990 • 231 citations

A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21.

1991 • 202 citations

The CDC25 protein of Saccharomyces cerevisiae promotes exchange of guanine nucleotides bound to ras.

1991 • 196 citations

Sequence homology shared by neurofibromatosis type-1 gene and IRA-1 and IRA-2 negative regulators of the RAS cyclic AMP pathway

1990 • 193 citations

The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization

1992 • 170 citations

Identification of a nucleotide exchange-promoting activity for p21ras.

1990 • 144 citations

A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr.

1991 • 129 citations

Regulatory mechanisms for ras proteins

1992 • 129 citations

Nerve Growth Factor Stimulation of the Ras-Guanine Nucleotide Exchange Factor and GAP Activities

1992 • 120 citations

Mechanistic Aspects of Signaling Through Ras in NIH 3T3 Cells

1992 • 88 citations

The Primary Structure of Skeletal Muscle Myosin Heavy Chain: IV. Sequence of the Rod, and the Complete 1,938-Residue Sequence of the Heavy Chain

1991 • 83 citations

Purification of a factor capable of stimulating the guanine nucleotide exchange reaction of ras proteins and its effect on ras-related small molecular mass G proteins.

1990 • 73 citations

Analysis of cloned mRNA sequences encoding subfragment 2 and part of subfragment 1 of alpha- and beta-myosin heavy chains of rabbit heart.

1984 • 69 citations

Regulation of p21ras activity

1991 • 60 citations

The CDC25 Protein of Saccharomyces cerevisiae Promotes Exchange of Guanine Nucleotides Bound to Ras

1991 • 42 citations

Four murine c-abl mRNAs arise by usage of two transcriptional promoters and alternative splicing.

1988 • 33 citations

Genetic analysis of ras homologs in yeasts.

1992 • 9 citations