A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Oncogenes and signal transduction

1991 • 2,816 citations

A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback

1989 • 2,555 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

Drosophila: a laboratory manual

1990 • 1,081 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

SH2 and SH3 domains: From structure to function

1992 • 977 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity

1984 • 913 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1992 • 714 citations

Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

1992 • 684 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

1991 • 641 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

Identification of a Protein that Binds to the SH3 Region of Abl and Is Similar to Bcr and GAP-rho

1992 • 553 citations

Sequence similarity of phospholipase C with the non-catalytic region of src

1988 • 541 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

1993 • 497 citations

Crystal structure of a Src-homology 3 (SH3) domain

1992 • 474 citations

Making a difference: The role of cell-cell interactions in establishing separate identities for equivalent cells

1992 • 452 citations

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1993 • 451 citations

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

1992 • 438 citations

Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

1986 • 421 citations

Sevenless , a Cell-Specific Homeotic Gene of Drosophila , Encodes a Putative Transmembrane Receptor with a Tyrosine Kinase Domain

1987 • 421 citations

The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

1990 • 420 citations

Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis

1992 • 414 citations

Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction

1990 • 412 citations

Involvement of p21ras in activation of extracellular signal-regulated kinase 2

1992 • 403 citations

let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein

1990 • 397 citations

The white gene as a marker in a new P-element vector for gene transfer inDrosophila

1987 • 355 citations

Solution Structure of the SH3 Domain of Src and Identification of Its Ligand-Binding Site

1992 • 334 citations

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells.

1990 • 327 citations

Raf functions downstream of Rasl in the Sevenless signal transduction pathway

1992 • 323 citations

Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)

1990 • 305 citations

A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase

1992 • 288 citations

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.

1992 • 286 citations

Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck

1991 • 284 citations

SH3 — an abundant protein domain in search of a function

1992 • 280 citations

The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog

1989 • 268 citations

Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity.

1990 • 264 citations

Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye

1991 • 255 citations

Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva

1991 • 246 citations

The Drosophila EGF receptor homolog (DER) gene is allelic to faint little ball, a locus essential for embryonic development

1989 • 235 citations

Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3

1990 • 209 citations

Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases

1991 • 209 citations

Sevenless : A Cell-Specific Homeotic Mutation of the Drosophila Eye

1986 • 197 citations

Evidence that autophosphorylation of solubilized receptors for epidermal growth factor is mediated by intermolecular cross-phosphorylation.

1989 • 193 citations

Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain

1988 • 177 citations

Ras Activation by Insulin and Epidermal Growth Factor through Enhanced Exchange of Guanine Nucleotides on p21^ras

1993 • 176 citations

Three-dimensional solution structure of the src homology 2 domain of c-abl

1992 • 174 citations

High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains.

1992 • 170 citations

Structure of an SH2 domain of the p85α subunit of phosphatidylinositol-3-OH kinase

1992 • 166 citations

Receptor tyrosine kinases: genetic evidence for their role in Drosophila and mouse development

1990 • 161 citations

Torso receptor activity is regulated by a diffusible ligand produced at the extracellular terminal regions of the Drosophila egg

1992 • 154 citations

Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways in Drosophila.

1993 • 99 citations

A site of tyrosine phosphorylation in the C terminus of the epidermal growth factor receptor is required to activate phospholipase C.

1992 • 98 citations

Mechanistic Aspects of Signaling Through Ras in NIH 3T3 Cells

1992 • 88 citations

Prepattern in the developing Drosophila eye revealed by an activated torso--sevenless chimeric receptor.

1992 • 80 citations

Identification of residues in GTPase-activating protein Src homology 2 domains that control binding to tyrosine phosphorylated growth factor receptors and p62

1992 • 78 citations

Neuronal development in the Drosophila retina: the sextra gene defines an inhibitory component in the developmental pathway of R7 photoreceptor cells.

1992 • 41 citations

CRYSTAL-STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN (SH2) OF THE V-SRC TYROSINE KINASE COMPLEXED WITH TYROSINE PHOSPHORYLATED PEPTIDES

1993 • 10 citations