Cloning of a Grb2 Isoform with Apoptotic Properties

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase

1991 • 1,779 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

1992 • 684 citations

Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors

1989 • 607 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

1993 • 555 citations

Identification of a Protein that Binds to the SH3 Region of Abl and Is Similar to Bcr and GAP-rho

1992 • 553 citations

Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice

1980 • 551 citations

The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity.

1991 • 224 citations

Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3

1990 • 209 citations

Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction.

1991 • 175 citations

Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries.

1992 • 168 citations

Identification of the SH3 Domain of GAP as an Essential Sequence for Ras-GAP-Mediated Signaling

1993 • 137 citations

Implication of GAP in Ras-Dependent Transactivation of a Polyoma Enhancer Sequence

1992 • 56 citations

The Saccharomyces cerevisiae SDC25 C-domain gene product overcomes the dominant inhibitory activity of Ha-Ras Asn-17.

1993 • 52 citations

Interference with endogenous ras function inhibits cellular responses to wounding.

1993 • 48 citations

Signal Transduction in Hamster Fibroblasts Overexpressing the Human EGF Receptor

1989 • 23 citations