Increasing cAMP attenuates activation of mitogen-activated protein kinase.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Metabolism of Isolated Fat Cells

1964 • 4,431 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Okadaic acid: a new probe for the study of cellular regulation

1990 • 1,396 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

The MAP kinase cascade is essential for diverse signal transduction pathways

1993 • 1,091 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 • 987 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product

1992 • 931 citations

[1] Assays of protein kinase

1983 • 832 citations

Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein.

1981 • 735 citations

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1992 • 714 citations

An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control

1990 • 701 citations

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro.

1987 • 604 citations

A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase.

1986 • 581 citations

Effects of Lipolytic and Antilipolytic Substances on Adenosine 3′,5′-Monophosphate Levels in Isolated Fat Cells

1968 • 555 citations

The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

1990 • 529 citations

Extracellular signal-regulated kinases: ERKs in progress.

1991 • 519 citations

Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.

1993 • 465 citations

The Relationship between the Insulin-binding Capacity of Fat Cells and the Cellular Response to Insulin

1971 • 464 citations

Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.

1991 • 344 citations

MAP kinase by any other name smells just as sweet

1992 • 341 citations

Monoclonal antibodies to phosphotyrosine

1988 • 242 citations

A phosphorylation site located in the NH2-terminal domain of c-Myc increases transactivation of gene expression.

1991 • 231 citations

Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases.

1992 • 202 citations

Increasing the cAMP content of IM-9 cells alters the phosphorylation state and protein kinase activity of the insulin receptor.

1986 • 182 citations

Evidence for an epidermal growth factor-stimulated protein kinase cascade in Swiss 3T3 cells. Activation of serine peptide kinase activity by myelin basic protein kinases in vitro.

1990 • 175 citations

Forskolin as an activator of cyclic AMP accumulation and lipolysis in rat adipocytes.

1982 • 141 citations

Purification and characterisation of the insulin‐stimulated protein kinase from rabbit skeletal muscle; close similarity to S6 kinase II

1991 • 117 citations

Phosphorylation of the glucose transporter in rat adipocytes. Identification of the intracellular domain at the carboxyl terminus as a target for phosphorylation in intact-cells and in vitro.

1990 • 110 citations

Phosphorylation of Purified Insulin Receptor by cAMP Kinase

1987 • 104 citations

The Insulin-Like Effect of Vanadate on Lipolysis in Rat Adipocytes Is Not Accompanied by an Insulin-Like Effect on Tyrosine Phosphorylation*

1989 • 98 citations

Insulin rapidly stimulates phosphorylation of a 46-kDa membrane protein on tyrosine residues as well as phosphorylation of several soluble proteins in intact fat cells.

1987 • 97 citations

Phosphorylation of the S. cerevisiae Cdc25 in response to glucose results in its dissociation from Ras

1992 • 85 citations

Characterization of a cyclic AMP-resistant Chinese hamster ovary cell mutant containing both wild-type and mutant species of type I regulatory subunit of cyclic AMP-dependent protein kinase.

1985 • 33 citations