Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF.

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Epidermal Growth Factor

1979 • 2,964 citations

Oncogenes and signal transduction

1991 • 2,816 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

In Vitro Cultivation of Human Tumors: Establishment of Cell Lines Derived From a Series of Solid Tumors2

1973 • 2,213 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

SH2 and SH3 domains: From structure to function

1992 • 977 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

The Cellular Functions of Small GTP-Binding Proteins

1990 • 881 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

1992 • 684 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

1993 • 555 citations

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1993 • 451 citations

Binding of Transforming Protein, P47 ^gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

1990 • 433 citations

Rat cell line 3y1 and its virogenic polyoma‐ and SV40‐transformed derivatives

1975 • 340 citations

Cellular ras activity and phospholipid metabolism

1988 • 331 citations

Molecular cloning of the bombesin/gastrin-releasing peptide receptor from Swiss 3T3 cells.

1991 • 330 citations

Epithelioid and fibroblastic rat kidney cell clones: Epidermal growth factor (EGF) receptors and the effect of mouse sarcoma virus transformation

1978 • 296 citations

Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries.

1992 • 168 citations

Mitogenesis in Response to PDGF and Bombesin Abolished by Microinjection of Antibody to PIP ₂

1988 • 146 citations

Rac and Rho in tune

1992 • 35 citations

Ras regulation: putting back the GTP

1992 • 20 citations

Missing links between receptors and ras

1992 • 16 citations