ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

ATP-regulated K+ channels in cardiac muscle

1983 • 2,350 citations

GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours

1989 • 1,405 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

Cloning of bovine GAP and its interaction with oncogenic ras p21

1988 • 666 citations

ras GTPase activating protein: Signal transmitter and signal terminator

1989 • 621 citations

Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain

1988 • 533 citations

On the mechanism of activation of muscarinic K+ channels by adenosine in isolated atrial cells: involvement of GTP-binding proteins

1986 • 510 citations

Molecular Cloning of Two Types of GAP Complementary DNA from Human Placenta

1988 • 492 citations

Direct Activation of Mammalian Atrial Muscarinic Potassium Channels by GTP Regulatory Protein G _k

1987 • 441 citations

Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells

1984 • 436 citations

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product

1988 • 402 citations

The mas oncogene encodes an angiotensin receptor

1988 • 390 citations

Ectopic Expression of the Serotonin 1c Receptor and the Triggering of Malignant Transformation

1989 • 355 citations

The α Subunit of the GTP Binding Protein G _k Opens Atrial Potassium Channels

1987 • 317 citations

Rapid β-Adrenergic Modulation of Cardiac Calcium Channel Currents by a Fast G Protein Pathway

1989 • 307 citations

The Effect of GTPase Activating Protein Upon Ras Is Inhibited by Mitogenically Responsive Lipids

1989 • 287 citations

The stimulatory G protein of adenylyl cyclase, Gs, also stimulates dihydropyridine-sensitive Ca2+ channels. Evidence for direct regulation independent of phosphorylation by cAMP-dependent protein kinase or stimulation by a dihydropyridine agonist.

1988 • 273 citations

The agonist effect of dihydropyridines on Ca channels

1984 • 264 citations

Purification of ras GTPase activating protein from bovine brain.

1988 • 255 citations

Acetylcholine analogue stimulates DNA synthesis in brain-derived cells via specific muscarinic receptor subtypes

1989 • 254 citations

Non-catalytic domains of cytoplasmic protein-tyrosine kinases: regulatory elements in signal transduction.

1988 • 250 citations

'Concentration‐clamp' study of gamma‐aminobutyric‐acid‐induced chloride current kinetics in frog sensory neurones.

1986 • 218 citations

Mechanism of muscarinic receptor-induced K+ channel activation as revealed by hydrolysis-resistant GTP analogues.

1988 • 205 citations

Reconstitution of Somatostatin and Muscarinic Receptor Mediated Stimulation of K⁺Channels by Isolated G_KProtein in Clonal Rat Anterior Pituitary Cell Membranes *

1987 • 188 citations

Identification of the GTP-binding protein encoded by Gi3 complementary DNA.

1988 • 169 citations

A C-terminal domain of GAP is sufficient to stimulate ras p21 GTPase activity.

1989 • 161 citations

Patch and whole cell calcium currents recorded simultaneously in snail neurons.

1984 • 116 citations

Biochemical and biological properties of the human N-ras p21 protein.

1987 • 106 citations

Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G protein of receptor-regulated K+ channels.

1988 • 104 citations

A Monoclonal Antibody to the α Subunit of G _k Blocks Muscarinic Activation of Atrial K ⁺ Channels

1988 • 85 citations

Isolation of GTP-binding proteins from myeloid HL-60 cells. Identification of two pertussis toxin substrates.

1987 • 66 citations

?-Adrenergic activation of the muscarinic K+ channel is mediated by arachidonic acid metabolites

1989 • 57 citations

Detection of activated Mr 21,000 protein, the product of ras oncogenes, using antibodies with specificity for amino acid 12.

1986 • 39 citations

Molecular mechanisms of signal transduction

2000 • 22 citations

Saxitoxin binding and "fast" sodium channel inhibition in sheep heart plasma membrane

1985 • 9 citations

Deleted Work

1955 • 0 citations