Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

The Cellular Functions of Small GTP-Binding Proteins

1990 • 881 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

The ras protein family: evolutionary tree and role of conserved amino acids

1991 • 573 citations

The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway

1987 • 491 citations

Bcr encodes a GTPase-activating protein for p21rac

1991 • 474 citations

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

1988 • 470 citations

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product

1991 • 424 citations

Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4.

1991 • 351 citations

Molecular cloning of cDNAs encoding the GAP-associated protein p190: Implications for a signaling pathway from ras to the nucleus

1992 • 343 citations

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells.

1990 • 327 citations

Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)

1990 • 305 citations

Insulin stimulation of gene expression mediated by p21ras activation.

1991 • 284 citations

The BCR gene encodes a novel serine/threonine kinase activity within a single exon

1991 • 273 citations

The ral gene: a new ras related gene isolated by the use of a synthetic probe.

1986 • 264 citations

Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells.

1990 • 242 citations

A Cytosolic Protein Catalyzes the Release of GDP from p21 ^ras

1990 • 231 citations

Dominant inhibitory mutations in the Mg(2+)-binding site of RasH prevent its activation by GTP.

1991 • 211 citations

Biochemical properties of Ha-ras encoded p21 mutants and mechanism of the autophosphorylation reaction.

1988 • 196 citations

The CDC25 protein of Saccharomyces cerevisiae promotes exchange of guanine nucleotides bound to ras.

1991 • 196 citations

Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42.

1990 • 172 citations

Enhancement of the GDP-GTP Exchange of RAS Proteins by the Carboxyl-Terminal Domain of SCD25

1990 • 152 citations

Identification of a nucleotide exchange-promoting activity for p21ras.

1990 • 144 citations

Homologous activators of ras in fission and budding yeast

1990 • 142 citations

Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression.

1991 • 138 citations

Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein.

1991 • 110 citations

cDNA sequence for human bcr, the gene that translocates to the abl oncogene in chronic myeloid leukaemia.

1987 • 107 citations

Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells.

1988 • 93 citations

Preferential inhibition of the oncogenic form of RasH by mutations in the GAP binding/“effector” domain

1991 • 83 citations

SDC25, a CDC25-like gene which contains a RAS-activating domain and is a dispensable gene of Saccharomyces cerevisiae.

1991 • 76 citations