Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition.

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

Two G Protein Oncogenes in Human Endocrine Tumors

1990 • 1,038 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro.

1987 • 604 citations

A dual receptor system is required for basic fibroblast growth factor activity

1991 • 589 citations

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

1991 • 579 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

cDNA cloning and expression of a hamster α‐thrombin receptor coupled to Ca²⁺ mobilization

1991 • 464 citations

Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6

1991 • 442 citations

Mast cell tryptase is a mitogen for cultured fibroblasts.

1991 • 392 citations

Microtubule‐associated‐protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells

1990 • 386 citations

MAP kinase by any other name smells just as sweet

1992 • 341 citations

A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases.

1988 • 282 citations

Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6.

1991 • 265 citations

Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin

1987 • 254 citations

Identification and characterization of a mitogen-activated S6 kinase.

1988 • 223 citations

MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways

1991 • 208 citations

Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase.

1990 • 194 citations

Serotonin as a growth factor

1990 • 180 citations

Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily.

1990 • 179 citations

The mitogenic signaling pathway of fibroblast growth factor is not mediated through polyphosphoinositide hydrolysis and protein kinase C activation in hamster fibroblasts.

1986 • 178 citations

Synthetic alpha-thrombin receptor peptides activate G protein-coupled signaling pathways but are unable to induce mitogenesis.

1992 • 178 citations

Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase.

1989 • 174 citations

Pertussis toxin inhibits thrombin-induced activation of phosphoinositide hydrolysis and Na+/H+ exchange in hamster fibroblasts.

1986 • 165 citations

Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapk.

1992 • 156 citations

Mitogen-activated 70K S6 kinase. Identification of in vitro 40 S ribosomal S6 phosphorylation sites.

1991 • 152 citations

Transmembrane Receptors and Intracellular Pathways that Control Cell Proliferation

1992 • 151 citations

EGF induces biphasic S6 kinase activation: Late phase is protein kinase C-dependent and contributes to mitogenicity

1989 • 122 citations

p42/mitogen-activated protein kinase as a converging target for different growth factor signaling pathways: use of pertussis toxin as a discrimination factor.

1991 • 121 citations

Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity.

1991 • 118 citations

Regulation of pp90rsk phosphorylation and S6 phosphotransferase activity in Swiss 3T3 cells by growth factor-, phorbol ester-, and cyclic AMP-mediated signal transduction.

1991 • 113 citations

Phosphorylation of ribosomal protein S6 by cAMP-dependent protein kinase and mitogen-stimulated S6 kinase differentially alters translation of globin mRNA.

1987 • 102 citations

N4-Acetylcytidine. A previously unidentified labile component of the small subunit of eukaryotic ribosomes

1978 • 101 citations

Phosphorylation of hepatic ribosomal protein S6 on 80 and 40 S ribosomes. Primary structure of S6 in the region of the major phosphorylation sites for cAMP-dependent protein kinases.

1984 • 91 citations

Strong and persistent activation of inositol lipid breakdown induces early mitogenic events but not Go to S phase progression in hamster fibroblasts. Comparison of thrombin and carbachol action in cells expressing M1 muscarinic acetylcholine receptors.

1990 • 89 citations

alpha-Thrombin-induced early mitogenic signalling events and G0 to S-phase transition of fibroblasts require continual external stimulation.

1985 • 83 citations

Thrombin exerts a dual effect on stimulated adenylate cyclase in hamster fibroblasts, an inhibition via a GTP-binding protein and a potentiation via activation of protein kinase C

1988 • 75 citations

Tyrosine kinase-activating growth factors potentiate thrombin- and AIF4- -induced phosphoinositide breakdown in hamster fibroblasts. Evidence for positive cross-talk between the two mitogenic signaling pathways.

1988 • 73 citations

EGF, PGF2α and insulin induce the phosphorylation of identical S6 peptides in Swiss mouse 3T3 cells: Effect of cAMP on early sites of phosphorylation

1984 • 71 citations

Coordinate regulation of pp90rsk and a distinct protein-serine/threonine kinase activity that phosphorylates recombinant pp90rsk in vitro.

1991 • 70 citations

Cyclic AMP inhibits mitogen‐induced DNA synthesis in hamster fibroblasts, regardless of the signalling pathway involved

1989 • 67 citations

Homologous desensitization of thrombin-induced phosphoinositide breakdown in hamster lung fibroblasts.

1988 • 57 citations

α-thrombin-induced tyrosine phosphorylation of 43,000- and 41,000-Mr proteins is independent of cytoplasmic alkalinization in quiescent fibroblasts

1986 • 54 citations

Molecular cloning of protein phosphatase inhibitor-1 and its expression in rat and rabbit tissues.

1990 • 48 citations

Growth factor requirements of Chinese hamster lung fibroblasts in serum free media: High mitogenic action of thrombin

1981 • 46 citations

Two distinct enzymes contribute to biphasic S6 phosphorylation in serum-stimulated chicken embryo fibroblasts.

1990 • 39 citations

Cloning, Functional Expression and Role in Cell Growth Regulation of a Hamster 5-HT2 Receptor Subtype

1991 • 38 citations

G Protein-Controlled Signal Transduction Pathways and the Regulation of Cell Proliferation

1992 • 36 citations

Identical Mr 70,000 S6 kinase is activated biphasically by epidermal growth factor: a phosphopeptide that characterizes the late phase.

1990 • 30 citations

Differential dependence of early and late increases in 1,2-diacylglycerol on the presence of catalytically active alpha-thrombin: evidence for regulation at the level of 1,2-diacylglycerol generation.

1991 • 13 citations

Fibroblast growth factor potentiates receptor- and nonreceptor-mediated stimulation of adenylate cyclase in hamster-fibroblasts

1989 • 13 citations