Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo.

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

1986 • 1,244 citations

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

1985 • 813 citations

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1991 • 785 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Autophosphorylation sites on the epidermal growth factor receptor

1984 • 730 citations

Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

1987 • 670 citations

Signal Transduction by the Platelet-Derived Growth Factor Receptor

1989 • 653 citations

Association between the PDGF receptor and members of the src family of tyrosine kinases

1990 • 650 citations

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

1991 • 641 citations

Two Different Subunits Associate to Create Isoform-Specific Platelet-derived Growth Factor Receptors

1989 • 633 citations

Isolation of a Novel Receptor cDNA Establishes the Existence of Two PDGF Receptor Genes

1989 • 610 citations

Binding of SH2 Domains of Phospholipase Cγ1, GAP, and Src to Activated Growth Factor Receptors

1990 • 608 citations

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

1991 • 585 citations

PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

1990 • 561 citations

Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins

1989 • 524 citations

Role of Phosphatidylinositol Kinase in PDGF Receptor Signal Transduction

1989 • 516 citations

Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor

1989 • 513 citations

Src homology region 2 domains direct protein-protein interactions in signal transduction.

1990 • 498 citations

Platelet-derived growth factor: mechanism of action and possible in vivo function.

1990 • 491 citations

Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle

1989 • 474 citations

A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor.

1988 • 467 citations

A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.

1991 • 443 citations

Binding of Transforming Protein, P47 ^gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

1990 • 433 citations

Binding of GAP to Activated PDGF Receptors

1990 • 396 citations

An 81 kd protein complexed with middle T antigen and pp60c-src: A possible phosphatidylinositol kinase

1987 • 346 citations

The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase

1989 • 342 citations

The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.

1990 • 314 citations

Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.

1988 • 314 citations

A Phosphatidylinositol-3 Kinase Binds to Platelet-Derived Growth Factor Receptors through a Specific Receptor Sequence Containing Phosphotyrosine

1991 • 294 citations

The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.

1991 • 264 citations

Expression of human class II major histocompatibility complex antigens using retrovirus vectors.

1987 • 257 citations

Non-catalytic domains of cytoplasmic protein-tyrosine kinases: regulatory elements in signal transduction.

1988 • 250 citations

Presence of an SH2 Domain in the Actin-Binding Protein Tensin

1991 • 248 citations

Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase.

1990 • 244 citations

Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3′-kinase SH2 domains: a model for SH2-mediated receptor-target interactions.

1992 • 241 citations

Platelet-derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase C.

1989 • 235 citations

The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity.

1991 • 224 citations

An investigation of protein subunit and domain interfaces

1988 • 208 citations

Platelet-Derived Growth Factor (PDGF)-Dependent Association of Phospholipase C-γ with the PDGF Receptor Signaling Complex

1990 • 204 citations

Isoform-specific induction of actin reorganization by platelet-derived growth factor suggests that the functionally active receptor is a dimer.

1989 • 191 citations

Ligand-induced dimerization of the platelet-derived growth factor receptor

1989 • 190 citations

Phosphorylation of middle T by pp60c-src: A switch for binding of phosphatidylinositol 3-kinase and optimal tumorigenesis

1989 • 178 citations

Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor.

1990 • 167 citations

A specific combination of substrates is involved in signal transduction by the kit-encoded receptor.

1991 • 155 citations

Phospholipase C-gamma, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine during the mitogenic response to CSF-1.

1989 • 145 citations

Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction.

1991 • 109 citations

Relationship of site-specific beta subunit tyrosine autophosphorylation to insulin activation of the insulin receptor (tyrosine) protein kinase activity.

1988 • 103 citations

Functions of the major tyrosine phosphorylation site of the PDGF receptor beta subunit.

1991 • 96 citations

A Tyrosine-Phosphorylated Carboxy-Terminal Peptide of the Fibroblast Growth Factor Receptor (Flg) Is a Binding Site for the SH2 Domain of Phospholipase C-γ1

1991 • 93 citations

Mutations of the Platelet-Derived Growth Factor Receptor That Cause a Loss of Ligand-Induced Conformational Change, Subtle Changes in Kinase Activity, and Impaired Ability To Stimulate DNA Synthesis

1989 • 89 citations

Geometry of interaction of metal ions with sulfur-containing ligands in protein structures

1989 • 79 citations

A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine

1991 • 57 citations

The Steel/W Transduction Pathway: Kit Autophosphorylation and Its Association with a Unique Subset of Cytoplasmic Signaling Proteins Is Induced by the Steel Factor

1991 • 48 citations

Platelet-derived growth factor (PDGF)-induced disulfide-linked dimerization of PDGF receptor in living cells.

1991 • 45 citations

Interactions of Phosphatidylinositol Kinase, GTPase-Activating Protein (GAP), and GAP-Associated Proteins with the Colony-Stimulating Factor 1 Receptor

1990 • 38 citations

Peptide antisera to human colony-stimulating factor 1 receptor detect ligand-induced conformational changes and a binding site for phosphatidylinositol 3-kinase.

1991 • 29 citations

Platelet-Derived Growth Factor (PDGF)-Induced Disulfide-Linked Dimerization of PDGF Receptor in Living Cells

1991 • 16 citations

Peptide Antisera to Human Colony-Stimulating Factor 1 Receptor Detect Ligand-Induced Conformational Changes and a Binding Site for Phosphatidylinositol 3-Kinase

1991 • 11 citations