T cells and aging (update February 1999)

Embryonic Stem Cell Lines Derived from Human Blastocysts

1998 • 15,541 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

The expanding universe of T-cell subsets: Th1, Th2 and more

1996 • 3,710 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

Changes in thymic function with age and during the treatment of HIV infection

1998 • 1,887 citations

Telomere reduction in human colorectal carcinoma and with ageing

1990 • 1,672 citations

Age Changes and Sex Differences in Serum Dehydroepiandrosterone Sulfate Concentrations throughout Adulthood

1984 • 1,345 citations

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

1997 • 1,244 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

Control of telomere length by the human telomeric protein TRF1

1997 • 1,197 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

1994 • 1,133 citations

Stress and immunity in humans: a meta-analytic review.

1993 • 1,096 citations

Age, Thymopoiesis, and CD4+ T-Lymphocyte Regeneration after Intensive Chemotherapy

1995 • 1,066 citations

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1998 • 1,001 citations

Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol.

1996 • 911 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

Activation of telomerase in human lymphocytes and hematopoietic progenitor cells.

1995 • 871 citations

Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.

1994 • 852 citations

The aging of hematopoietic stem cells

1996 • 850 citations

The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T–lymphocyte response

1996 • 832 citations

Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men

1997 • 822 citations

Chronic stress alters the immune response to influenza virus vaccine in older adults.

1996 • 791 citations

Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy".

1994 • 788 citations

Admission criteria for immunogerontological studies in man: The senieur protocol

1984 • 754 citations

Telomerase activity in normal and malignant hematopoietic cells.

1995 • 748 citations

Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.

1993 • 743 citations

Genetic determination of telomere size in humans: a twin study of three age groups.

1994 • 738 citations

Oxidative DNA damage and senescence of human diploid fibroblast cells.

1995 • 697 citations

The rate of telomere sequence loss in human leukocytes varies with age

1998 • 652 citations

Myc activates telomerase

1998 • 650 citations

Increased cytokine production in mononuclear cells of healthy elderly people

1993 • 648 citations

Lifespan of human lymphocyte subsets defined by CD45 isoforms

1992 • 642 citations

Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects

1990 • 581 citations

Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative.

1993 • 577 citations

NF-AT components define a family of transcription factors targeted in T-cell activation

1994 • 573 citations

Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes.

1996 • 560 citations

Relationship between donor age and the replicative lifespan of human cells in culture: A reevaluation

1998 • 547 citations

The immunology of exceptional individuals: the lesson of centenarians

1995 • 538 citations

HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies

1997 • 527 citations

Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood.

1992 • 510 citations

Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression.

1996 • 499 citations

Total cholesterol and risk of mortality in the oldest old

1997 • 487 citations

Glutathione in Human Plasma: Decline in Association with Aging, Age-Related Macular Degeneration, and Diabetes

1998 • 487 citations

AGEING, IMMUNE RESPONSE, AND MORTALITY

1974 • 480 citations

CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity.

1996 • 479 citations

The Association of Plasma IL-6 Levels With Functional Disability in Community-Dwelling Elderly

1997 • 476 citations

Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans.

1981 • 473 citations

In vivo loss of telomeric repeats with age in humans

1991 • 469 citations

Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis

1996 • 452 citations

Co-stimulation in T cell responses

1997 • 430 citations

Genetic control of the CD4/CD8 T-cell ratio in humans

1995 • 426 citations

Human naive and memory T lymphocytes differ in telomeric length and replicative potential.

1995 • 424 citations

Helper T‐Cell Subsets: Phenotype, Function and the Role of Lymphokines in Regulating their Development

1991 • 423 citations

Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase

1998 • 419 citations

Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing.

1996 • 418 citations

Developmental and maturational changes in human blood lymphocyte subpopulations

1992 • 415 citations

Evidence for a Critical Telomere Length in Senescent Human Fibroblasts

1995 • 391 citations

Differential Expression of Telomerase Activity in Hematopoietic Progenitors from Adult Human Bone Marrow

1996 • 390 citations

Anergic T Cells as Suppressor Cells in Vitro

1994 • 389 citations

Melatonin enhances IL-2, IL-6, and IFN-gamma production by human circulating CD4+ cells: a possible nuclear receptor-mediated mechanism involving T helper type 1 lymphocytes and monocytes.

1997 • 381 citations

Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts.

1996 • 378 citations

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

1996 • 377 citations

IMPACT OF EPIDEMIC TYPE A INFLUENZA IN A DEFINED ADULT POPULATION

1980 • 376 citations

Decline in CD28+ T cells in centenarians and in long-term T cell cultures: A possible cause for both in vivo and in vitro immunosenescence

1994 • 375 citations

An Enhanced Immune Response in Mice Lacking the Transcription Factor NFAT1

1996 • 375 citations

Immune Parameters in a Longitudinal Study of a Very Old Population of Swedish People: A Comparison Between Survivors and Nonsurvivors

1995 • 374 citations

BCL2 translocation frequency rises with age in humans.

1994 • 372 citations

T cell memory is short-lived in the absence of antigen.

1991 • 367 citations

Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells.

1994 • 367 citations

The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes.

1990 • 353 citations

Thymic involution with ageing: obsolescence or good housekeeping?

1996 • 351 citations

Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans

1997 • 334 citations

The Cellular and Subcellular Bases of Immunosenescence

1989 • 326 citations

DNA damage and repair in telomeres: relation to aging.

1995 • 326 citations

Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

1992 • 322 citations

Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents.

1996 • 305 citations

Cell-Mediated Immunity as a Predictor of Morbidity and Mortality in Subjects Over 60

1990 • 304 citations

Alterations of Antioxidant Enzymes and Oxidative Damage to Macromolecules in Different Organs of Rats During Aging

1998 • 298 citations

Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span.

1992 • 295 citations

Mechanism of Telomerase Induction during T Cell Activation

1996 • 291 citations

Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: Progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone

1997 • 291 citations

Chronic Tumor Necrosis Factor Alters T Cell Responses by Attenuating T Cell Receptor Signaling

1997 • 287 citations

GH3 pituitary adenoma cells can reverse thymic aging in rats.

1986 • 282 citations

Pineal control of aging: effect of melatonin and pineal grafting on aging mice.

1994 • 276 citations

In vivo estimates of division and death rates of human T lymphocytes.

1995 • 276 citations

Dehydroepiandrosterone enhances IL2 production and cytotoxic effector function of human T cells

1991 • 275 citations

Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor.

1994 • 271 citations

Beneficial effects of oral zinc supplementation on the immune response of old people

1981 • 270 citations

Novel repair action of vitamin C upon in vivo oxidative DNA damage

1998 • 260 citations

T cell reconstitution after bone marrow transplantation into adult patients does not resemble T cell development in early life.

1995 • 259 citations

Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals

1998 • 258 citations

Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1

1991 • 257 citations

CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to centenarians: implications for T cell memory

1996 • 254 citations

T-cell regeneration: all repertoires are not created equal

1997 • 246 citations

Thymic aging and T‐cell regeneration

1997 • 244 citations

Antigen-independent changes in naive CD4 T cells with aging.

1996 • 240 citations

Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress

1998 • 237 citations

Accelerated telomere shortening in young recipients of allogeneic bone-marrow transplants

1998 • 236 citations

Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease.

1996 • 233 citations

Cell aging in vivo and in vitro

1997 • 232 citations

Increased Apoptosis of T Cell Subsets in Aging Humans: Altered Expression of Fas (CD95), Fas Ligand, Bcl-2, and Bax

1998 • 231 citations

The Effect of Genetic Factors for Longevity: A Comparison of Identical and Fraternal Twins in the Swedish Twin Registry

1998 • 228 citations

Unexpected expansions of CD8-bearing cells in old mice.

1993 • 228 citations

Decrease of the lymphoproliferative response to varicella-zoster virus antigen in the aged

1981 • 219 citations

Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women

1993 • 212 citations

The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis

1994 • 210 citations

Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men

1992 • 207 citations

Telomerase regulation during entry into the cell cycle in normal human T cells.

1996 • 206 citations

Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging

1997 • 202 citations

Thymic Function Can Be Accurately Monitored by the Level of Recent T Cell Emigrants in the Circulation

1998 • 193 citations

Early stages in the development of human T, natural killer and thymic dendritic cells

1998 • 192 citations

Resistance to Apoptosis and Elevated Expression of Bcl-2 in Clonally Expanded CD4+CD28− T Cells from Rheumatoid Arthritis Patients

1998 • 192 citations

CD28 Expression in T Cell Aging and Human Longevity

1998 • 192 citations

The effect of donor age on the processing of UV-damaged DNA by cultured human cells: Reduced DNA repair capacity and increased DNA mutability

1996 • 191 citations

Effect of Age on Cytotoxic T Lymphocyte Memory as well as Serum and Local Antibody Responses Elicited by Inactivated Influenza Virus Vaccine

1993 • 189 citations

Functional properties of CD4+CD28− T cells in the aging immune system

1998 • 189 citations

Enumeration of T lymphocyte subsets by monoclonal antibodies in young and aged humans.

1981 • 187 citations

Constitutive activation of NF-kappa B in an animal model of aging

1997 • 185 citations

Aging-related Deficiency of CD28 Expression in CD4+ T Cells Is Associated with the Loss of Gene-specific Nuclear Factor Binding Activity

1998 • 183 citations

Necessity of the assessment of health status in human immunogerontological studies: Evaluation of the senieur protocol

1990 • 183 citations

Dysregulation between TH1 and TH2 T cell subpopulations in the elderly

1996 • 178 citations

Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice.

1996 • 175 citations

Immune response to influenza vaccination in a large healthy elderly population

1999 • 175 citations

Quantitative intracellular cytokine measurement: age-related changes in proinflammatory cytokine production

1998 • 174 citations

Immune dysregulation in the aging human lung.

1996 • 173 citations

Neutrophils and low-grade inflammation in the seemingly normal aging human lung

1998 • 173 citations

Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets

1998 • 172 citations

An investigation of antioxidant status, DNA repair capacity and mutation as a function of age in humans

1995 • 170 citations

Cytokine production and lymphocyte subpopulations in aged humans. An assessment during nocturnal sleep

1995 • 170 citations

Suppressor Lymphocytes in Young and Aged Humans

1977 • 169 citations

Physical activity and immune senescence in men

1995 • 167 citations

Human mast cells produce the CD4+ T lymphocyte chemoattractant factor, IL-16.

1997 • 164 citations

Activation of Immune Function by Dehydroepiandrosterone (DHEA) in Age-Advanced Men

1997 • 161 citations

Short telomeres on human chromosome 17p

1998 • 159 citations

Severe growth defect in mouse cells lacking the telomerase RNA component

1998 • 159 citations

Impact of Influenza on Mortality in Relation to Age and Underlying Disease, 1967–1989

1993 • 157 citations

Experimental elongation of telomeres extends the lifespan of immortal x normal cell hybrids.

1996 • 156 citations

Nutritional regulation of immunity and risk of infection in old age.

1989 • 152 citations

In vivo human somatic mutation: frequency and spectrum with age

1992 • 152 citations

Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice.

1995 • 151 citations

Alloantigen-specific cytotoxic and suppressor T lymphocytes are derived from phenotypically distinct precursors.

1983 • 151 citations

Thymic function in young/old chimeras: substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution

1998 • 151 citations

CD28 engagement and proinflammatory cytokines contribute to T cell expansion and long-term survival in vivo.

1997 • 148 citations

Overexpression of the heat shock protein 70 enhances the TCR/CD3- and Fas/Apo-1/CD95-mediated apoptotic cell death in Jurkat T cells.

1997 • 146 citations

Phenotypic and Immunohistological Analyses of the Human Adult Thymus: Evidence for an Active Thymus during Adult Life

1997 • 146 citations

THE IMMUNOLOGIC THEORY OF AGING

1969 • 146 citations

Natural Killer Cells in the Late Decades of Human Life

1997 • 143 citations

Copper/zinc ratio and systemic oxidant load: effect of aging and aging-related degenerative diseases

1998 • 142 citations

Intrinsic and Extrinsic Control of Hemopoietic Stem Cell Numbers: Mapping of a Stem Cell Gene

1997 • 142 citations

Effect of a Continuous Gamma Irradiation at a Very Low Dose on the Life Span of Mice

1998 • 142 citations

A physiological amount of zinc supplementation: effects on nutritional, lipid, and thymic status in an elderly population

1993 • 141 citations

Bacterial Meningitis in the Elderly

1984 • 137 citations

The effect of immunosuppressive agents on the induction of nuclear factors that bind to sites on the interleukin 2 promoter.

1990 • 137 citations

Oligoclonal T cell proliferation in patients with rheumatoid arthritis and their unaffected siblings

1996 • 136 citations

Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians

1998 • 135 citations

In vitro potentiation of lymphocyte activation by dehydroepiandrosterone, androstenediol, and androstenetriol.

1994 • 133 citations

Oxidative DNA damage measured in human lymphocytes: large differences between sexes and between countries, and correlations with heart disease mortality rates

1998 • 133 citations

Hypothesis: Interventions That Increase the Response to Stress Offer the Potential for Effective Life Prolongation and Increased Health

1996 • 132 citations

Effect of Vitamin C Supplements on Cell-Mediated Immunity in Old People

1983 • 129 citations

Longevity of lobsters is linked to ubiquitous telomerase expression

1998 • 128 citations

Effects of low-copper diets on human immune response

1995 • 128 citations

Mouse liver T cells: Their change with aging and in comparison with peripheral T cells

1997 • 126 citations

Functional anatomy of the thymic microenvironment.

1991 • 126 citations

Lower serum concentrations of cytokines in elderly patients with pneumonia and the impaired production of cytokines by peripheral blood monocytes in the elderly.

1996 • 126 citations

Reversibility of the thymic involution and of age-related peripheral immune dysfunctions by zinc supplementation in old mice

1995 • 125 citations

Retrovirus-mediated expression of a DNA repair protein in bone marrow protects hematopoietic cells from nitrosourea-induced toxicity in vitro and in vivo.

1995 • 123 citations

Perspective: Aging and Infectious Diseases: Past, Present, and Future

1997 • 121 citations

Human T lymphocytes possess a limited in vitro life span

1989 • 121 citations

Influence of the main histocompatibility complex on ageing in mice

1977 • 120 citations

There is substantial agreement among interspecies estimates of DNA repair activity

1996 • 120 citations

Age-Related Decreases in IL-2 Production by Human T Cells Are Associated with Impaired Activation of Nuclear Transcriptional Factors AP-1 and NF-AT

1996 • 119 citations

Understanding the mechanism of the age-change of thymic function to promote T cell differentiation

1994 • 119 citations

Aged T cells are hyporesponsive to costimulation mediated by CD28.

1994 • 116 citations

Involvement of the Ink4 proteins p16 and p15 in T-lymphocyte senescence

1998 • 115 citations

The Repertoire of CD4+ CD28− T Cells in Rheumatoid Arthritis

1996 • 113 citations

Cytokine production after influenza vaccination in a healthy elderly population

1998 • 113 citations

Cytogenetic studies in leucocytes on the general population: subjects of ages 65 years and more

1963 • 112 citations

Changes in Lymphocyte Subsets, Interleukin 2, and Soluble Interleukin 2 Receptor in Old and Very Old Age

1996 • 110 citations

The pattern of T lymphocyte differentiation is altered during thymic involution

1995 • 110 citations

Retarding Effect of Dietary Restriction on the Accumulation of 8-Hydroxy-2′-Deoxyguanosine in Organs of Fischer 344 Rats During Aging

1997 • 109 citations

Increase of interleukin 6 and decrease of interleukin 2 production during the ageing process are influenced by the health status

1998 • 108 citations

Circadian Secretions of IL-2, IL-12, IL-6 and IL-10 in Relation to the Light/Dark Rhythm of the Pineal Hormone Melatonin in Healthy Humans

1998 • 107 citations

CD4 ligand IL-16 inhibits the mixed lymphocyte reaction.

1996 • 107 citations

Vitamin E Supplementation Decreases Lung Virus Titers in Mice Infected with Influenza

1997 • 107 citations

Oligoclonality of CD8 + T cells in health and disease: Aging, infection, or immune regulation?

1996 • 107 citations

Lymphocyte response is enhanced by supplementation of elderly subjects with selenium-enriched yeast

1991 • 105 citations

Serum Dehydroepiandrosterone (DHEA) and DHEA Sulfate Are Negatively Correlated with Serum Interleukin-6 (IL-6), and DHEA Inhibits IL-6 Secretion from Mononuclear Cells in Man in Vitro: Possible Link between Endocrinosenescence and Immunosenescence

1998 • 105 citations

Zinc and immunocompetence in the elderly: baseline data on zinc nutriture and immunity in unsupplemented subjects

1987 • 104 citations

Bacteremic Urinary Tract Infection in Older People

1996 • 104 citations

Vitamin D3 is a potent inhibitor of tumor cell-induced angiogenesis.

1996 • 103 citations

Regulation of an extrathymic T-cell development pathway by oncostatin M

1996 • 102 citations

Replicative Senescence in the Immune System: Impact of the Hayflick Limit on T-Cell Function in the Elderly

1998 • 101 citations

The influence of age on the canine immune system

1996 • 101 citations

Nutritional influences on immune response in healthy aged persons

1998 • 100 citations

Phenotype of lymphocyte subsets after autologous peripheral blood stem cell transplantation

1997 • 100 citations

Cytokine production by T lymphocytes from young and aged mice.

1996 • 99 citations

Zeta chain and CD28 are poorly expressed on T lymphocytes from chronic lymphocytic leukemia.

1996 • 99 citations

Disease incidence and longevity are unaltered by dietary antioxidant supplementation initiated during middle age in C57BL/6 mice

1998 • 99 citations

Serum free IGF‐I, total IGF‐I, IGFBP‐1 and IGFBP‐3 levels in an elderly population: relation to age and sex steroid levels

1998 • 98 citations

Aging and lymphocyte subpopulations: whole-blood analysis of immune markers in a large population sample of healthy elderly individuals

1998 • 98 citations

Investigations of the lymphokine system in elderly individuals

1993 • 98 citations

Emergence of oligoclonal t cell populations following therapeutic t cell depletion in rheumatoid arthritis

1995 • 97 citations

Human T‐cell clones in long‐term culture as a model of immunosenescence

1997 • 96 citations

Age-Related Reductions in the Activation of Mitogen-Activated Protein Kinases p44mapk/ERK1 and p42mapk/ERK2 in Human T Cells Stimulated via Ligation of the T Cell Receptor Complex

1996 • 94 citations

Monoclonal antibodies against P-glycoprotein, an MDR1 gene product, inhibit interleukin-2 release from PHA-activated lymphocytes.

1996 • 93 citations

Increased apoptosis of CD45RO− T cells with aging

1997 • 92 citations

Endogenous Melatonin Levels and the Fate of Exogenous Melatonin: Age Effects

1998 • 92 citations

Alternative pathways for the selection of antigen-specific peripheral T cells

1996 • 91 citations

The Role of Nutrition in Immunity in the Aged

2009 • 91 citations

Replicative senescence of normal human oral keratinocytes is associated with the loss of telomerase activity without shortening of telomeres.

1998 • 90 citations

The expanded null cell compartment in ageing: increase in the number of natural killer cells and changes in T-cell and NK-cell subsets in human blood.

1986 • 89 citations

Spontaneous loss and alteration of antigen receptor expression in mature CD4+ T cells.

1990 • 89 citations

Effect of ageing on human plasma glutathione concentrations as determined by high-performance liquid chromatography with fluorimetric detection

1995 • 88 citations

Age‐Related Decline in Interleukin 2 Production in Response to Influenza Vaccine

1990 • 88 citations

Chagasic Patients Lack CD28 Expression on Many of Their Circulating T Lymphocytes

1996 • 88 citations

Evidence of enhanced type 2 immune response and impaired upregulation of a type 1 response in frail elderly nursing home residents

1997 • 88 citations

Dysregulation of IL-10 production with aging: Possible linkage to the age-associated decline in DHEA and its sulfated derivative

1996 • 87 citations

Age-Related Differences in Cytokine Secretion

1994 • 87 citations

Prevalence of organ-specific and non organ-specific autoantibodies in healthy centenarians

1997 • 87 citations

Suppression of apoptosis by Bcl-2 or Bcl-xL promotes susceptibility to mutagenesis.

1996 • 87 citations

Telomerase Regulation, Cell Cycle, and Telomere Stability in Primitive Hematopoietic Cells

1997 • 86 citations

An investigation of mutation as a function of age in humans

1994 • 86 citations

Cytokine Antagonists in Aged Subjects and Their Relation With Cellular Immunity

1997 • 86 citations

Effect of dietary restriction on in vivo somatic mutation in mice

1993 • 85 citations

Detection and measurement of cytokines

1992 • 85 citations

Age Patterns of the Life Table Aging Rate for Major Causes of Death in Japan, 1951-1990

1997 • 84 citations

Cell division in the compartment of naive and memory T lymphocytes

1996 • 84 citations

Susceptibility to apoptosis of T lymphocytes from elderly humans is associated with increased in vivo expression of functional Fas receptors

1997 • 84 citations

Plasticity of neuroendocrine-thymus interactions during aging

1997 • 84 citations

The weight of the human thymus gland at necropsy.

1980 • 83 citations

Expanded CD4+CD45RO+ phenotype and defective proliferative response in T lymphocytes from patients with Crohn's disease

1996 • 83 citations

Depression and immunity: A meta-analytic review.

1993 • 82 citations

Age-associated changes in human T cell phenotype and function

1994 • 81 citations

Immortalization of human T cell clones by Herpesvirus saimiri. Signal transduction analysis reveals functional CD3, CD4, and IL-2 receptors.

1993 • 81 citations

Excessive intake of zinc impairs immune responses

1984 • 80 citations

Immunodeficiency of Aging

1997 • 80 citations

Human T cell activation through the activation-inducer molecule/CD69 enhances the activity of transcription factor AP-1.

1992 • 80 citations

Up-regulation of telomerase activity in human lymphocytes

1996 • 79 citations

Evidence for Lowered Induction of Nuclear Factor Kappa B in Activated Human T Lymphocytes during Aging

1996 • 79 citations

Control of fibroblast senescence and activation of programmed cell death

1994 • 78 citations

In Vitro Secretion of Cytokines by Human Bone Marrow: Effects of Age and Estrogen Status

1998 • 78 citations

Dehydroepiandrosterone (DHEA) treatment reverses the impaired immune response of old mice to influenza vaccination and protects from influenza infection

1995 • 78 citations

Excessive apoptosis of mature T lymphocytes is a characteristic feature of human immune senescence

1996 • 78 citations

Exercise, immunity and aging

1997 • 77 citations

Tissue-specific distribution and age-dependent increase of human CD11b+ T cells.

1993 • 77 citations

Age-related changes in T cell surface markers: a longitudinal analysis in genetically heterogeneous mice

1997 • 76 citations

Age-associated changes in CD8+ and CD16+ cell reactivity: clonal analysis

1990 • 74 citations

Similar Gene Expression Pattern in Senescent and Hyperoxic-Treated Fibroblasts

1998 • 74 citations

Nutrition and Immunoregulation. Significance for Host Resistance to Tumors and Infectious Diseases in Humans and Rodents

1992 • 74 citations

Immunosenescence in HIV Pathogenesis

1997 • 73 citations

T cell cultures and the Hayflick limit

1984 • 72 citations

A comprehensive analysis of peripheral blood lymphocytes in healthy aged humans by flow cytometry

1993 • 72 citations

Stress Response of Senescent T Lymphocytes Reduced hsp70 Is Independent of the Proliferative Block

1994 • 72 citations

Age-Related Changes in the Peroxyl Radical Scavenging Capacity of Human Plasma

1997 • 70 citations

Age and gender dependent levels of glutathione and glutathione S- transferases in human lymphocytes

1998 • 70 citations

Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed cell death.

1997 • 69 citations

In vivo antioxidant status, DNA damage, mutation and DNA repair capacity in cultured lymphocytes from healthy 75- to 80-year-old humans

1997 • 68 citations

Decreased proliferative capacity and increased susceptibility to activation-induced cell death in late-passage human cd4+ tcr2+ cultured T cell clones

1996 • 68 citations

Cytokine production in varicella zoster virus-stimulated limiting dilution lymphocyte cultures

1994 • 68 citations

A functional link for major TCR expansions in healthy adults caused by persistent Epstein-Barr virus infection.

1998 • 68 citations

Thyroid autoimmunity and aging

1998 • 68 citations

The relationship of dehydroepiandrosterone sulfate (DHEAS) to endocrine- metabolic parameters and functional status in the oldest-old. Results from an Italian study on healthy free-living over-ninety-year-olds

1996 • 67 citations

CD4 memory T cell levels predict life span in genetically heterogeneous mice

1997 • 67 citations

Decreased Immunity and Increased Morbidity in the Elderly

2009 • 67 citations

Changes in Telomerase Activity and Telomere Length during Human T Lymphocyte Senescence

1997 • 67 citations

Effect of age on lymphocyte proliferation

1987 • 67 citations

Changes in Lymphocyte Subsets and Immune Competence in Very Advanced Age

1990 • 66 citations

Effect of melatonin and pineal grafting on thymocyte apoptosis in aging mice

1996 • 66 citations

Differential Tyrosine Phosphorylation of Zeta Chain Dimers in Mouse CD4 T Lymphocytes: Effect of Age

1997 • 66 citations

The photoperiod transducer melatonin and the immune-hematopoietic system

1998 • 65 citations

Cytokine production and aging: overproduction of IL-8 in elderly males in response to lipopolysaccharide

1994 • 65 citations

Long-term culture of monoclonal human T lymphocytes: models for immunosenescence?

1995 • 64 citations

The Decline of Cell-mediated Immunity in Aging Mice

1974 • 63 citations

Short- and long-term beta-carotene supplementation do not influence T cell-mediated immunity in healthy elderly persons

1997 • 63 citations

Diminished heat-shock protein synthesis following mitogen stimulation of lymphocytes from aged donors

1989 • 63 citations

Alterations in sympathetic innervation of thymus and spleen in aged mice

1997 • 62 citations

Signal Transduction in LPS-Activated Aged and Young Monocytes

1998 • 62 citations

Does multivitamin supplementation prevent infections in healthy elderly subjects? A controlled trial.

1993 • 61 citations

Sex and parity modulate cytokine production during murine ageing

1997 • 61 citations

Annually repeated influenza vaccination improves humoral responses to several influenza virus strains in healthy elderly

1997 • 61 citations

Effect of age on serum immunoglobulin G subclass antibody responses to inactivated influenza virus vaccine

1994 • 60 citations

Influence of age on the signal transduction of T cells in mice

1993 • 60 citations

HIV infection and aging: mechanisms to explain the accelerated rate of progression in the older patient

1997 • 60 citations

Modulation of Cytokine Production by Dehydroepiandrosterone (DHEA) Plus Melatonin (MLT) Supplementation of Old Mice

1998 • 60 citations

Age-Related Persistent Clonal Expansions of CD28−Cells: Phenotypic and Molecular TCR Analysis Reveals both CD4+and CD4+CD8+Cells with Identical CDR3 Sequences

1998 • 60 citations

Dietary restriction from middle age attenuates age-associated lymphoma development and interleukin 6 dysregulation in C57BL/6 mice.

1994 • 60 citations

T lymphocyte proliferative capability to defined stimuli and costimulatory CD28 pathway is not impaired in healthy centenarians

1997 • 60 citations

Naive murine neonatal T cells undergo apoptosis in response to primary stimulation.

1996 • 59 citations

Altered expression of various receptors on T cells in young and old mice after mitogenic stimulation: a flow cytometric analysis

1997 • 59 citations

Improvement of the immunoglobulin subclass response to influenza vaccine in elderly nursing-home residents by the use of high-dose vaccines

1993 • 59 citations

Impairment of signal transduction in T cells from old mice

1997 • 58 citations

Cellular basis of decreased immune responses to pneumococcal vaccines in aged mice

1996 • 58 citations

The effect of age on the antigen-presenting mechanism in limiting dilution precursor cell frequency analysis

1984 • 58 citations

Aging accelerates but life-long dietary restriction suppresses apoptosis-related Fas expression on hepatocytes.

1997 • 58 citations

Long-Term in vitro Growth of Human T Cell Clones: Can Postmitotic ‘Senescent’ Cell Populations Be Defined?

1994 • 58 citations

Effect of aging on cytokine production in normal and experimental systemic lupus erythematosus afflicted mice

1997 • 57 citations

Bone marrow declines as a site of B-cell precursor differentiation with age: relationship to thymus involution.

1994 • 57 citations

Retarded thymic involution and massive germinal center formation in NF-ATp-deficient mice

1998 • 57 citations

Diminished activation of the MAP kinase pathway in CD3-stimulated T lymphocytes from old mice

1997 • 57 citations

Cellular distribution of protein kinase C isozymes in CD3‐mediated stimulation of human T lymphocytes with aging

1995 • 57 citations

Maturation of B Cell Precursors Is Impaired in Thymic-Deprived Nude and Old Mice

1998 • 56 citations

T-cell immunosenescence and its clinical relevance in man

1998 • 55 citations

On a causal mechanism of chronic thymic involution in man

1994 • 54 citations

Prevalence of CD8+ T-Cell Expansions in Relation to Age in Healthy Individuals

1998 • 54 citations

T cell activation in the elderly: Evidence for specific deficiencies in T cell/accessory cell interactions

1990 • 54 citations

Evidence for in vitro senescence of T-lymphocytes cultured from normal human peripheral blood

1981 • 53 citations

Age-related tyrosine-specific protein phosphorylation defect in human T lymphocytes activated through CD3, CD4, CD8 or the IL-2 receptor

1996 • 53 citations

Supplementation with Selenium Restores Age-Related Decline in Immune Cell Function

1995 • 52 citations

Dehydroepiandrosterone Sulfate: A Biomarker of Primate Aging Slowed by Calorie Restriction

1997 • 52 citations

Responses to influenza vaccination in different T-cell subsets: a comparison of healthy young and older adults

1998 • 52 citations

Highly sensitive ELISA for soluble Fas in serum: increased soluble Fas in the elderly

1996 • 52 citations

In vitro antioxidant treatment recovers proliferative responses of anergic CD4+ lymphocytes from human immunodeficiency virus-infected individuals

1996 • 52 citations

Accessory Function and Properties of Monocytes from Healthy Elderly Humans for T Lymphocyte Responses to Mitogen and Antigen

1993 • 51 citations

Immunological Functions of Aged Human Monocytes

1995 • 51 citations

Activation of p21ras/MAPK Signal Transduction Molecules Decreases with Age in Mitogen-Stimulated T Cells from Rats

1998 • 51 citations

Progressive increase of CD7- T cells in human blood lymphocytes with ageing

1994 • 50 citations

Modulation of immune dysfunction during murine leukaemia retrovirus infection of old mice by dehyroepiandrosterone sulphate (DHEAS)

1997 • 49 citations

The use of oral dehydroepiandrosterone sulfate as an adjuvant in tetanus and influenza vaccination of the elderly

1996 • 49 citations

Aging and Immune Function: A Possible Role for Growth Hormone

1996 • 49 citations

Reduced Immune Responses in Rhesus Monkeys Subjected to Dietary Restriction

1996 • 49 citations

Collection of peripheral blood stem cells from normal donors 60 years of age or older

1997 • 48 citations

Effects of caloric restriction on age-related oxidative modifications of macromolecules and lymphocyte proliferation in rats

1995 • 48 citations

Penetrating Anti-DNA Monoclonal Antibodies Induce Activation of Human Peripheral Blood Mononuclear Cells

1998 • 48 citations

1,25-Dihydroxyvitamin D3 and the Immune System

1989 • 48 citations

Is the Phenotypic Combination A1B8Cw7DR3 a Marker for Male Longevity?

1994 • 48 citations

Differences in the degree of depletion, rate of recovery, and the preferential elimination of naive CD4+ T cells by anti-CD4 monoclonal antibody (GK1.5) in young and aged mice.

1995 • 48 citations

Differential Expression of Fas Antigen and Bcl-2 Protein on CD4+ T Cells, CD8+ T Cells, and Monocytes

1995 • 48 citations

Age-related decline in proliferative potential of purified stem cell candidates.

1994 • 48 citations

Major Histocompatibility Complex Regulation of Cytokine Production

1996 • 48 citations

Growth Hormone and Aging

1998 • 46 citations

Functional disability and antibody response to influenza vaccine in elderly patients in a Dutch nursing home

1996 • 46 citations

Human lymphocyte telomerase is genetically regulated

1998 • 45 citations

Reduced Activation of Transcriptional Factor AP-1 among Peripheral Blood T Cells from Elderly Humans after PHA Stimulation: Restorative Effect of Phorbol Diesters

1993 • 45 citations

Vaccine-Induced Antibodies to Heterologous Influenza A H1N1 Viruses: Effects of Aging and “Original Antigenic Sin”

1994 • 45 citations

Evaluation of live, cold-adapted influenza A and B virus vaccines in elderly and high-risk subjects

1998 • 45 citations

Decreased steady state c-myc mRNA in activated T cell cultures from old humans is caused by a smaller proportion of T cells that transcribe the c-myc gene.

1990 • 44 citations

Interleukin-12 release by mitogen-stimulated mononuclear cells in the elderly

1998 • 44 citations

Oxidative stress suppresses transcription factor activities in stimulated lymphocytes

1998 • 44 citations

Extrusion of the P glycoprotein substrate rhodamine-123 distinguishes CD4 memory T cell subsets that differ in IL-2-driven IL-4 production.

1994 • 44 citations

Enhancement of leukocyte functions in aged mice supplemented with the antioxidant thioproline

1998 • 44 citations

The effect of age on mitogen responsive T cell precursors in human beings is completely restored by interleukin-2

1992 • 43 citations

The Lack of Association Between Aging and Postvaccination Levels of IgG Antibody to Capsular Polysaccharides of Streptococcus pneumoniae

1996 • 43 citations

Idiosyncratic Alterations of TCR Size Distributions Affecting Both CD4 and CD8 T Cell Subsets in Aging Mice

1998 • 43 citations

Aging and immune response to exercise

1998 • 43 citations

Immunogenicity of standard and low dose vaccination using yeast-derived recombinant hepatitis B surface antigen in elderly volunteers

1994 • 42 citations

Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice

1998 • 42 citations

Ageing, nutritional status and immune response.

1998 • 42 citations

Expansion of T cells negative for CD28 expression in hiv infection. Relation to activation markers and cell adhesion molecules, and correlation with prognostic markers

1996 • 41 citations

Insulin Exposure and Aging Theory

1997 • 40 citations

Marker Loci Associated With Life Span in Genetically Heterogeneous Mice

1998 • 40 citations

Impairment of lymphocyte activities in depressed aged subjects

1991 • 40 citations

Aging and the Immune Response to Tetanus Toxoid: Diminished Frequency and Level of Cellular Immune Reactivity to Antigenic Stimulation

1998 • 40 citations

Attenuated stress responses in young and old human lymphocytes

1997 • 39 citations

Adjuvant effect of low-dose interleukin-2 on antibody response to influenza virus vaccination in healthy elderly subjects

1994 • 39 citations

Zinc and metallothioneins on cellular immune effectiveness during liver regeneration in young and old mice

1997 • 39 citations

Psychoneuroimmunology and Aging

1998 • 39 citations

Altered major histocompatibility complex‐restricted antigen recognition by T cells from elderly humans

1992 • 39 citations

Age-dependent remodeling of rat thymus. Morphological and cytofluorimetric analysis from birth up to one year of age

1998 • 38 citations

Variation of Heat Shock Protein 70 through the Cell Cycle in HL-60 Cells and Its Relationship to Apoptosis

1997 • 38 citations

HLA Phenotypes in Healthy Aged Subjects

1997 • 38 citations

Dietary· supplements of antioxidants reduce hprt mutant frequency in splenocytes of aging mice

1995 • 38 citations

Immune response of the elderly to rabies vaccines

1994 • 38 citations

Demonstration of identical expanded clones within both CD8+ CD28+ and CD8+ CD28− T cell subsets in HIV type 1-infected individuals

1998 • 38 citations

A New Type of Cytokine Receptor Antagonist Directly Targeting gp130

1998 • 37 citations

Genetic control of immune responsiveness, aging and tumor incidence

1997 • 37 citations

The effect of age on antigen retention in lymphoid follicles and in collagenous tissue of mice

1984 • 37 citations

Effects of Insulin-Like Growth Factor Administration and Bone Marrow Transplantation on Thymopoiesis in Aged Mice

1998 • 37 citations

The Age-Related Decline in the Induction of IL-2 Transcription Is Correlated to Changes in the Transcription Factor NFAT

1995 • 37 citations

The prolongation of survival in mice by dietary antioxidants depends on their age by the start of feeding this diet

1996 • 37 citations

Cytokine Production by Subsets of CD4 Memory T Cells Differing in P-Glycoprotein Expression: Effects of Aging

1997 • 36 citations

Impaired expression of hematopoietic growth factors: A candidate mechanism for the hematopoietic defect of aging

1996 • 36 citations

Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals

1995 • 36 citations

Effects of the aged microenvironment on CD4+ T cell maturation

1997 • 35 citations

Telomere shortening in peripheral blood cells was related with aging but not with white blood cell count

1996 • 35 citations

In vitro T cell activation in elderly individuals: failure in CD69 and CD71 expression

1996 • 34 citations

Age-related changes of expression of IL-2 receptor subunits and kinetics of IL-2 internalization in T cells after mitogenic stimulation

1988 • 34 citations

IL-4-responsive human helper T cell clones are resistant to growth inhibition by tumor necrosis factor-alpha.

1989 • 34 citations

Mortality and Biomarkers of Aging in Heterogeneous Stock (HS) Mice

1998 • 33 citations

Lymphocyte content of amyloid precursor protein is increased in Down's syndrome and aging

1997 • 33 citations

Dehydroepiandrosterone Treatment Is Not Beneficial to the Immune Response to Influenza in Elderly Subjects

1997 • 33 citations

Aged-Rodent Models of Long-Term Growth Hormone Therapy: Lack of Deleterious Effect on Longevity

1998 • 33 citations

Expression of c-fos, c-jun and jun B in peripheral blood lymphocytes from young and elderly adults

1992 • 32 citations

Relevance of oxidative stress to the limited replicative capacity of cultured human diploid cells: the limit of cumulative population doublings increases under low concentrations of oxygen and decreases in response to aminotriazole

1995 • 32 citations

Quantitative and qualitative analysis of anti-tetanus toxoid antibody response in the elderly. Humoral immune response enhancement by thymostimulin

1993 • 32 citations

CD11b+CD28-CD4+ human T cells: activation requirements and association with HLA-DR alleles.

1996 • 32 citations

HLA‐B8,DR3 PHENOTYPE AND LYMPHOCYTE RESPONSES TO PHYTOHAEMAGGLUTININ

1990 • 31 citations

Feedback regulation of T cell development: manifestations in aging

1996 • 31 citations

Decreased maturation of T-cell populations in the healthy elderly: Influence of nutritional factors on the appearance of double negative CD4-, CD8-, CD2+ cells

1994 • 31 citations

Down‐regulation of CD28 via Fas (CD95): influence of CD28 on T‐cell apoptosis

1998 • 31 citations

Differential Expression of Various T Cell Surface Markers in Young and Elderly Subjects

1995 • 31 citations

Thymocyte progenitors and T cell development in aging

1997 • 31 citations

The Age‐Associated Increase in Autoreactive Immunoglobulins Reflects a Quantitative Increase in Specificities Detectable at Lower Concentrations in Young Mice

1996 • 30 citations

Mouse Strain-Dependent Changes in Frequency and Proliferation of Hematopoietic Stem Cells During Aging: Correlation Between Lifespan and Cycling Activity

1997 • 30 citations

Aged Murine T-lymphocytes Are More Resistant to Oxidative Damage Due to the Predominance of the Cells Possessing the Memory Phenotype

1996 • 30 citations

Induction and repair of benzo[a]pyrene-DNA adducts in C57BL/6 and BALB/c mice: association with aging and longevity

1995 • 30 citations

Phytohemagglutinin induced proliferation by aged lymphocytes: Reduced expression of high affinity interleukin-2 receptors and interleukin-2 secretion

1988 • 30 citations

Effects of six-month administration of recombinant human growth hormone to healthy elderly subjects

1997 • 30 citations

Age-related enhancement of tumor necrosis factor (TNF) production in mice

1995 • 29 citations

Vitamin E prevents oxidative modification of brain and lymphocyte band 3 proteins during aging.

1996 • 29 citations

Effect of age on mitogen induced protein tyrosine phosphorylation in human T cell and its subsets: down-regulation of tyrosine phosphorylation of ZAP-70

1998 • 28 citations

Age-dependent changes in the expression of dopamine receptor subtypes in human peripheral blood lymphocytes

1996 • 28 citations

Suppressor cell function in man: Evidence for altered sensitivity of responder cells with age

1979 • 28 citations

In Vitro Effects of Melatonin on Mitogen-Induced Lymphocyte Proliferation and Cytokine Expression in Young and Old Rats

1997 • 28 citations

Age-related changes in the absolute number of CD95 positive cells in T cell subsets in the blood

1998 • 28 citations

Distinctions Between CD8+ and CD4+ T-Cell Regenerative Pathways Result in Prolonged T-Cell Subset Imbalance After Intensive Chemotherapy

1997 • 28 citations

Dehydroepiandrosterone (DHEA) Sulfate Prevents Reduction in Tissue Vitamin E and Increased Lipid Peroxidation Due to Murine Retrovirus Infection of Aged Mice

1998 • 28 citations

Age-Sensitive T Cell Phenotypes Covary in Genetically Heterogeneous Mice and Predict Early Death From Lymphoma

1994 • 28 citations

In vitro genetically aberrant T-cell clones with continuous growth are associated with atopic dermatitis

1994 • 27 citations

GROWTH HORMONE AS THERAPY FOR OLDER MEN AND WOMEN

1998 • 27 citations

Aging of the recipients but not of the bone marrow donors enhances autoimmunity in syngeneic radiation chimeras

1997 • 27 citations

Enhanced immune responses and resistance against infection in aged mice conferred by Flu-ISCOMs vaccine correlate with up-regulation of costimulatory molecule CD86

1998 • 26 citations

Age-Related Changes of Cytokine Production by Murine Helper T Cell Subpopulations

1997 • 26 citations

An Age-Related Decrease in Rescue from T Cell Death Following Costimulation Mediated by CD28

1996 • 26 citations

Effects of a protein-free diet or food restriction on the immune system of Wistar and Buffalo rats at different ages

1993 • 26 citations

The Hsp90-specific inhibitor, geldanamycin, blocks CD28-mediated activation of human T lymphocytes

1998 • 26 citations

Stress Exacerbates Age-Related Decrements in the Immune Response to an Experimental Influenza Viral Infection

1998 • 26 citations

Dihydrotestosterone exerts a depressive influence on the production of interleukin-4 (IL-4), IL-5, and gamma-interferon, but not IL-2 by activated murine T cells

1991 • 25 citations

Immunogenicity and efficacy of DNA vaccines encoding influenza A proteins in aged mice

1998 • 25 citations

Bone marrow progenitor cell growth and karyotype changes in healthy 88‐year‐old subjects

1995 • 25 citations

Age-dependent remodeling of peripheral blood CD4+ CD8+ T lymphocytes in cynomolgus monkeys

1998 • 25 citations

Immunogenetic analysis of the HLA complex with alloreactive T cell clones

1983 • 24 citations

Phenotypic and Functional Characterization of Tumor Infiltrating Lymphocytes in Mycosis Fungoides: Continuous Growth of CD4+ CD45R+ T-Cell Clones with Suppressor-Inducer Activity

1990 • 24 citations

Altered Switch in Lipid Composition During T-Cell Blast Transformation in the Healthy Elderly

1995 • 24 citations

Expression of the human T cell antigen receptor complex in advanced age

1988 • 24 citations

Increased acute-phase response and renal amyloidosis in aged CD2-fas-transgenic mice.

1997 • 24 citations

Melatonin: immune modulation of spleen cells in young, middle-aged and senescent mice

1998 • 24 citations

Age- and microenvironment-associated influences by platelet-derived growth factor on T cell function.

1994 • 23 citations

Age-related variations in human lymphocyte DNA

1981 • 23 citations

Antagonistic interactions among T cell subsets of old mice revealed by limiting dilution analysis.

1995 • 23 citations

TCR signaling regulates thymic organization: lessons from TCR-transgenic mice

1997 • 23 citations

Moderate Caloric Restriction Prevents the Age-Related Decline in Growth Hormone Receptor Signal Transduction

1996 • 23 citations

Telomerase Activity, Telomere Length, and Chromosome Aberrations in the Extension of Life Span of Human Embryo Cells Induced by Low-dose X-rays.

1998 • 23 citations

Thymocytopoiesis in aging: the bone marrow-thymus axis

1997 • 23 citations

HLA-B8,DR3 haplotype affects lymphocyte blood levels

1997 • 22 citations

An antibody specific for interleukin‐6 reverses age‐associated changes in spontaneous and induced cytokine production in mice

1997 • 22 citations

Zinc Status and Serum Testosterone Levels of Healthy Adults

1996 • 22 citations

Reciprocal Expression of P-Glycoprotein and TAP1 Accompanied by Higher Expression of MHC Class I Antigens in T Cells of Old Mice

1996 • 21 citations

Genetic instability in human T-lymphocytes

1998 • 21 citations

Long-term melatonin supplementation does not recover the impairment of natural killer cell activity and lymphocyte proliferation in aging mice

1997 • 21 citations

Effect of Oxidative Stress on Lymphocytes from Elderly Subjects

1998 • 21 citations

Telomerase Activity in Candidate Stem Cells From Fetal Liver and Adult Bone Marrow

1998 • 21 citations

Transient Normalization of Lymphocyte Blastogenic and Specific Antibody Responses Following Boosting of Healthy Elderly Subjects With Tetanus Toxoid

1993 • 20 citations

Age-related impairment of T cell proliferative responses related to the decline of CD28+ T cell subsets

1997 • 20 citations

Treatment of old mice with IL-2 corrects dysregulated IL-2 and IL-4 production

1996 • 20 citations

PULMONARY INFLAMMATORY RESPONSES AND CYTOKINE AND ANTIOXIDANT mRNA LEVELS IN THE LUNGS OF YOUNG AND OLD C57BL/6 MICE AFTER EXPOSURE TO TEFLON FUMES

1998 • 20 citations

Relationship between Plasma IGF-I Levels,in VitroCorrelates of Immunity, and Human Senescence

1998 • 19 citations

Essential Role of the Thymus to Reconstitute Naive (CD45RA+) T-Helper Cells After Human Allogeneic Bone Marrow Transplantation

1997 • 19 citations

Augmentation of the immune response to influenza vaccine by acetylsalicylic acid: a clinical trial in a geriatric population.

1994 • 19 citations

Changes in the amount and level of phosphorylation of p56lck in PBL from aging humans

1998 • 19 citations

Interleukin-6 (IL-6) Prevents Activation-Induced Cell Death: IL-2–Independent Inhibition of Fas/fasL Expression and Cell Death

1998 • 19 citations

Evaluation of presence and functional activity of potentially self-reactive T cells in aged mice

1996 • 18 citations

Diminished Cell-Cell Binding by Lymphocytes from Healthy, Elderly Humans: Evidence for Altered Activation of LFA-1 Function With Age

1995 • 18 citations

Determinants of survival: An analysis of the effects of age at observation and length of the predictive period

1996 • 18 citations

Phytohemagglutinin induced changes of membrane lipid packing , c-myc and c-myb encoded protein expression in human lymphocytes during aging

1992 • 18 citations

Frequency and cytokine profile of HPRT mutant T cells in HIV-infected and healthy donors: implications for T cell proliferation in HIV disease.

1997 • 17 citations

Immunogenicity and Efficacy of a DNA Vaccine in Aged Mice

1998 • 17 citations

Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-gamma in normal human T lymphocytes

1996 • 16 citations

Pattern of cytokine expression in circulation CD57+ T cells from long-term renal allograft recipients

1998 • 16 citations

Induction of thymic hyperplasia and suppression of splenic T cells by lesioning of the anterior hypothalamus in aging Wistar rats

1997 • 16 citations

Aging and Lymphocyte Subsets in the Spleen and Peripheral Blood of the Sprague-Dawley Rat

1997 • 16 citations

Influence of age on the production of Fos and Jun by influenza virus-exposed T cells

1994 • 16 citations

Age-dependent appearance of non-major histocompatibility complex-restricted helper T cells.

1993 • 16 citations

The generation of CD4 T lymphocytes in patients with HIV infection.

1995 • 15 citations

T cell telomere length in HIV-1 infection: No evidence for increased CD4+ T cell turnover

1997 • 15 citations

The hematopoietic stem cell in elderly patients with leukemia.

1996 • 15 citations

Age-related defects in CD2 receptor-induced activation in human T-cell subsets.

1995 • 15 citations

Expansion of CD4+CD7- T helper cells with a TH0-TH2 function in kidney transplant recipients.

1995 • 15 citations

Differential Expression of p53 Tumor Suppressor Protein and IL-2 in Activated T Cells from Elderly Humans

1998 • 15 citations

Effects of aging on the dynamics of lymphocyte organ distribution in mice: use of a radioiodinated cell membrane probe

1998 • 14 citations

Vaccination-induced HI antibody to influenza A(H1N1) viruses in poorly primed adults under circumstances of low antigenic drift

1993 • 14 citations

Promotion of interleukin-2 activity as a strategy for ‘rejuvenating’ geriatric immune function

1997 • 14 citations

Age-Related Decline of Perforin Expression in Human Cytotoxic T Lymphocytes and Natural Killer Cells

1998 • 13 citations

Memory and the lifespan of human T lymphocytes.

1993 • 13 citations

Age-related changes in plasma lipid peroxidation and antioxidant system in humans and rats

1997 • 13 citations

Correlation between the antibody response to influenza vaccine and helper T cell subsets in healthy ageing

1996 • 13 citations

Neonatal T cells as a model system to study the possible in vitro senescence of lymphocytes

1987 • 13 citations

Life-span, T-cell responses, and incidence of lymphomas in congenic mice.

1995 • 13 citations

P-glycoprotein plays an insignificant role in the presentation of antigenic peptides to CD8+ T cells.

1998 • 12 citations

In vivo and in vitro study of the primary and secondary antibody response to a bacterial antigen in aged mice.

1995 • 11 citations

Downregulation of DNA topoisomerase I in old versus young human diploid fibroblasts

1997 • 11 citations

Age-related changes in CD4+ T-cell subsets associated with prolonged skin graft survival in aging rats.

1993 • 11 citations

Redox state as a correlate of senescence and wasting and as a target for therapeutic intervention

1998 • 10 citations

Failure of aged rats to accumulate eosinophils in allergic inflammation of the airway

1997 • 10 citations

The Association of Ageing with Calcium Active Hormone Status in Men

1994 • 10 citations

Age-related loss of immunoregulatory function in peripheral blood CD8 T cells

1998 • 9 citations

Effect of reduced glutathione on mitochondrial parameters of proliferating splenocytes from young and old rats

1994 • 9 citations

CD95 Expression in Aged Mice Infected with Tuberculosis

1998 • 9 citations

Elderly high NK responders are characterized by intensive proliferative response to PHA and Con A and optimal health status

1993 • 8 citations

Inhibition of IL-2 production by Nil-2-a in murine T cells

1998 • 8 citations

Effect of rIL-2 treatment on anti-tetanus toxoid response in the elderly

1997 • 8 citations

Age-related events in active T lymphocyte subpopulation. A morphological study

1994 • 8 citations

Low MLR stimulation index and depressed CD28 antigen expression in long-term renal transplant recipients

1998 • 6 citations

Function of GH/IGF-I axis in aging: Multicenter study in 152 healthy elderly subjects with different degrees of physical activity

1997 • 6 citations

Lymphocyte aging in allophenic mice

1985 • 6 citations

Comparison between serum interleukin-2 concentrations in healthy adult and elderly subjects

1996 • 6 citations

Aging and immune function (184-187)

1999 • 6 citations

Depressed Expression of CD 28 Antigen on Lymphocytes in Long-Term Kidney Transplant Patients

1998 • 6 citations

T Cell Receptor V-Segment Frequencies in Aged Individuals

1996 • 5 citations

Thymus influences liver functions through hypothalamus-pituitary-gonad axis in rats

1996 • 4 citations

Flow cytometric analysis of CD3/TCR complex, zinc, and glucocorticoid‐mediated regulation of apoptosis and cell cycle distribution in thymocytes from old mice

1998 • 4 citations

HPRT mutant T cells in the peripheral blood and synovial tissue of patients with rheumatoid arthritis

1998 • 4 citations

Life extension and stress resistance in Caenorhabditis elegans modulated by the tkr-1 gene

1999 • 3 citations

Surface antigen expression in spleen cells of C57B1/6 mice during ageing : influence of sex and parity

1997 • 2 citations

Decreased Resistance to Primary Intravenous Cryptococcus neoformans Infection in Aged Mice despite Adequate Resistance to Intravenous Rechallenge

1998 • 2 citations

Elevated frequency of the C2 allele of the ETS-I oncogene in elderly subjects

1996 • 2 citations

Genetics of life span in mice

1994 • 2 citations