Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Structure and function of telomeres

1991 • 3,524 citations

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

1997 • 2,256 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

1997 • 1,786 citations

A theory of marginotomy

1973 • 1,770 citations

Clonal selection and learning in the antibody system

1996 • 1,710 citations

Telomere reduction in human colorectal carcinoma and with ageing

1990 • 1,672 citations

Origin of Concatemeric T7DNA

1972 • 1,591 citations

Telomere elongation in immortal human cells without detectable telomerase activity.

1995 • 1,249 citations

Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

1994 • 1,133 citations

Activation of telomerase in human lymphocytes and hematopoietic progenitor cells.

1995 • 871 citations

Heterogeneity in telomere length of human chromosomes

1996 • 861 citations

Telomeres: Beginning to Understand the End

1995 • 855 citations

Structure and variability of human chromosome ends.

1990 • 833 citations

Loss of a yeast telomere: Arrest, recovery, and chromosome loss

1993 • 787 citations

Telomerase activity in normal and malignant hematopoietic cells.

1995 • 748 citations

Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.

1993 • 743 citations

Genetic determination of telomere size in humans: a twin study of three age groups.

1994 • 738 citations

Qualitative Analysis of Immune Function in Patients with the Acquired Immunodeficiency Syndrome

1985 • 737 citations

A Human Telomeric Protein

1995 • 689 citations

Analysis of somatic mutation in five B cell subsets of human tonsil.

1994 • 667 citations

A Mammalian Telomerase-Associated Protein

1997 • 656 citations

Telomere length and replicative aging in human vascular tissues.

1995 • 630 citations

Sugar and Disease

1972 • 532 citations

TELOMERASES

1992 • 531 citations

Mechanism and Regulation of Immunoglobulin Isotype Switching

1993 • 516 citations

Complex Complexes: Signaling at the TCR

1996 • 512 citations

ON IMMUNOLOGICAL MEMORY

1996 • 482 citations

In vivo loss of telomeric repeats with age in humans

1991 • 469 citations

Human naive and memory T lymphocytes differ in telomeric length and replicative potential.

1995 • 424 citations

Regulated expression of telomerase activity in human T lymphocyte development and activation.

1996 • 416 citations

Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues.

1996 • 403 citations

Differential Expression of Telomerase Activity in Hematopoietic Progenitors from Adult Human Bone Marrow

1996 • 390 citations

Telomerase Activity in Hematopoietic Cells Is Associated with Self-Renewal Potential

1996 • 385 citations

Telomere dynamics in an immortal human cell line.

1994 • 380 citations

Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts.

1996 • 378 citations

Human telomeres contain at least three types of G–rich repeat distributed non-randomly

1989 • 374 citations

Germinal center development

1997 • 370 citations

Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes

1994 • 360 citations

Regulation of Telomerase Activity in Immortal Cell Lines

1996 • 360 citations

New Concepts in the Immunopathogenesis of HIV Infection

1995 • 323 citations

Life and Death in Germinal Centers (Redux)

1996 • 315 citations

Mechanism of Telomerase Induction during T Cell Activation

1996 • 291 citations

Activation of telomerase in a human tumor.

1994 • 289 citations

T Cell Telomere Length in HIV-1 Infection: No Evidence for Increased CD4 ⁺ T Cell Turnover

1996 • 288 citations

Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation

1993 • 283 citations

Telomerase Regulation, Cell Cycle, and Telomere Stability in Primitive Hematopoietic Cells

1997 • 273 citations

Telomere lengthening and telomerase activation during human B cell differentiation

1997 • 263 citations

Somatic hypermutation

1995 • 248 citations

Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex.

1996 • 230 citations

Variability at the Telomeres of the Human X/Y Pseudoautosomal Region

1986 • 229 citations

Telomerase regulation during entry into the cell cycle in normal human T cells.

1996 • 206 citations

Block in Anaphase Chromosome Separation Caused by a Telomerase Template Mutation

1997 • 204 citations

Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells

1996 • 201 citations

Memory B and T Cells

1991 • 183 citations

Telomerase and cancer: revisiting the telomere hypothesis

1996 • 167 citations

The germinal center: a crucible for lymphocyte selection

1996 • 166 citations

Telomerase in the early detection of cancer.

1997 • 162 citations

Telomerase activation in normal B lymphocytes and non-Hodgkin's lymphomas

1996 • 154 citations

Growth factors can enhance lymphocyte survival without committing the cell to undergo cell division.

1995 • 152 citations

CD28 ligands CD80 (B7-1) and CD86 (B7-2) induce long-term autocrine growth of CD4⁺ T cells and induce similar patterns of cytokine secretion in vitro

1995 • 152 citations

Bcl-2 Modulates Telomerase Activity

1997 • 149 citations

Is rapid proliferation in B centroblasts linked to somatic mutation in memory B cell clones?

1988 • 135 citations

Telomere Length, Telomerase Activity, and Replicative Potential in HIV Infection: Analysis of CD4+ and CD8+T Cells from HIV-discordant Monozygotic Twins

1997 • 131 citations

Spontaneous and glucocorticoid-induced apoptosis in human mature T lymphocytes

1995 • 128 citations

Selective inhibition of telomerase activity during terminal differentiation of immortal cell lines.

1996 • 127 citations

Regulation of telomerase RNA template expression in human T lymphocyte development and activation.

1997 • 112 citations

Telomerase Activity Is Induced in Human Peripheral B Lymphocytes by the Stimulation to Antigen Receptor

1997 • 110 citations

TRF1, a mammalian telomeric protein

1997 • 109 citations

Oligoclonality of CD8 + T cells in health and disease: Aging, infection, or immune regulation?

1996 • 107 citations

Telomerase is up-regulated in human germinal center B cells in vivo and can be re-expressed in memory B cells activated in vitro.

1997 • 98 citations

Cytological detection of telomerase activity using an in situ telomeric repeat amplification protocol assay.

1997 • 97 citations

Telomerase activity and in situ telomerase RNA expression in malignant and non-malignant lymph nodes.

1997 • 93 citations

Telomerase Regulation, Cell Cycle, and Telomere Stability in Primitive Hematopoietic Cells

1997 • 86 citations

Telomerase and cancer: revisiting the telomere hypothesis

1996 • 85 citations

Telomerase Activity Is Induced by the Stimulation to Antigen Receptor in Human Peripheral Lymphocytes

1996 • 83 citations

Down-regulation of Telomerase Activity Is an Early Event in the Differentiation of HL60 Cells

1996 • 81 citations

Changes in Telomerase Activity and Telomere Length during Human T Lymphocyte Senescence

1997 • 67 citations

Regulation of CD28 costimulation in human CD8+ T cells.

1997 • 52 citations

Identification of a tonsil IgD⁺ B cell subset with phenotypical and functional characteristics of germinal center B cells

1996 • 32 citations

Cellular aging and cell death

1996 • 32 citations

Telomerase activity in human hematopoietic progenitor cells.

1997 • 16 citations

Subtelomeric as well as telomeric sequences are lost from chromosomes in proliferating B lymphocytes

1993 • 16 citations

T cell development and selection in the thymus.

1992 • 15 citations

Telomere dynamics and cytogenetic changes in human hematologic neoplasias: A working hypothesis

1997 • 15 citations

Germinal centers: A second childhood for lymphocytes

1997 • 15 citations

Apoptosis and the B Cell Response to Antigen

1997 • 13 citations