Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice.

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas Molecule

1994 • 1,120 citations

Fas transduces activation signals in normal human T lymphocytes.

1993 • 521 citations

Interleukin‐6: A Cytokine for Gerontolgists

1993 • 457 citations

Human CD2 3′-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice

1989 • 385 citations

Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene.

1993 • 287 citations

Pgp‐1^hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A

1989 • 279 citations

Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice.

1990 • 264 citations

Growth factors as survival factors: Regulation of apoptosis

1994 • 201 citations

Effect of Age on Cytotoxic T Lymphocyte Memory as well as Serum and Local Antibody Responses Elicited by Inactivated Influenza Virus Vaccine

1993 • 189 citations

Memory B and T Cells

1991 • 183 citations

The age-associated increase in IFN-gamma synthesis by mouse CD8+ T cells correlates with shifts in the frequencies of cell subsets defined by membrane CD44, CD45RB, 3G11, and MEL-14 expression.

1993 • 168 citations

Age‐related changes in lymphokine production related to a decreased number of CD45RB^hi CD4⁺ T cells

1991 • 154 citations

The structure of the human CD2 gene and its expression in transgenic mice.

1988 • 150 citations

Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk.

1993 • 144 citations

Age-related effects in T cell activation and proliferation

1993 • 124 citations

Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosis

1995 • 123 citations

Age‐related accumulation of LFA‐1^high cells in a CD8⁺CD45RA^high T cell population

1993 • 101 citations

Increased function of P-glycoprotein in T lymphocyte subsets of aging mice.

1993 • 99 citations

Origin of CD4-CD8-B220+ T cells in MRL-lpr/lpr mice. Clues from a T cell receptor beta transgenic mouse.

1993 • 98 citations

Abnormal thymocyte development and production of autoreactive T cells in T cell receptor transgenic autoimmune mice.

1991 • 97 citations

Age‐associated changes in mitogen‐induced protein phosphorylation in murine T lymphocytes

1992 • 82 citations

Defective maintenance of T cell tolerance to a superantigen in MRL-lpr/lpr mice.

1992 • 71 citations

Accelerated programmed cell death of MRL-lpr/lpr T lymphocytes.

1992 • 71 citations

Splenic and inguinal lymph node T cells of aged mice respond differently to polyclonal and antigen-specific stimuli

1992 • 67 citations

Differential tyrosine-specific protein phosphorylation in mouse T lymphocyte subsets. Effect of age.

1993 • 63 citations

The Effect of Influenza Vaccination on IL2 Production in Healthy Elderly: Implications for Current Vaccination Practices

1992 • 57 citations

Pituitary epithelial cell implants reverse the accumulation of CD4-CD8- lymphocytes in thymus glands of aged rats.

1992 • 52 citations

L-selectin expression differentiates T cells isolated from different lymphoid tissues in cattle but does not correlate with memory.

1992 • 46 citations

IgE regulation and lymphokine patterns in aging humans

1992 • 45 citations

Natural Regulators of T-Cell Lymphokine Production In Vivo

1992 • 45 citations

The effect of age on mitogen responsive T cell precursors in human beings is completely restored by interleukin-2

1992 • 43 citations

Human B cel proliferative responses during aging. Reduced RNA synthesis and DNA replication after signal transduction by surface immunoglobulins compared to B cell antigenic determinants CD20 and CD40

1991 • 40 citations

Thymic Involution in Aging Prospects for Correction

1992 • 35 citations

Cellular Determinants of Age-related Decrements in the T-cell Mitogen Response of B6CBAF1 Mice

1992 • 34 citations

Age-related impairment of early and late events of signal transduction in mouse immune cells

1993 • 32 citations

Effect of synthetic thymic humoral factor (THF-γ2) on T cell activities in immunodeficient ageing mice

1992 • 31 citations

Thymopentin reduces the susceptibility of aged mice to cutaneous leishmaniasis by modulating CD4 T-cell subsets.

1992 • 30 citations

A mathematical model of the effect of aging on bone marrow cells colonizing the thymus

1993 • 26 citations

Signal transduction in human B cells during aging: alterations in stimulus-induced phosphorylations of tyrosine and serine/threonine substrates and in cytosolic calcium responsiveness.

1991 • 24 citations

Mixed interleukins and thymosin fraction V synergistically induce T lymphocyte development in hydrocortisone-treated aged mice

1992 • 20 citations

Patterns of dual lymphocyte development in co-cultures of foetal thymus and lymphohaemopoietic cells from young and old mice.

1992 • 18 citations

Variations in thymocyte susceptibility to clonal deletion during ontogeny. Implications for neonatal tolerance.

1991 • 17 citations

Comparison of CD3 and CD2 activation pathways in T cells from young and elderly adults

1992 • 17 citations

Age- and strain-related differences in murine spleen cell responses to different activation signals

1992 • 14 citations

T Cell Differentiation and Functional Maturation in Aging Mice

1993 • 13 citations

Hormones, genetic program and immunosenescence.

1992 • 10 citations

Pgp-1^ t lymphocytes accumulate with age in mice and respond poorly to concanavalin.

1989 • 1 citations