Immune dysregulation in the aging human lung.

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 • 1,950 citations

The Lung: Scientific Foundations

1991 • 1,181 citations

Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution

1986 • 1,093 citations

The respiratory burst of phagocytes.

1984 • 914 citations

Oxygen Metabolism and the Toxic Properties of Phagocytes

1980 • 886 citations

Bronchoalveolar lavage

2012 • 873 citations

Elasticity of human lungs in relation to age

1968 • 500 citations

Standardized single breath normal values for carbon monoxide diffusing capacity.

1981 • 499 citations

Interleukin‐6: A Cytokine for Gerontolgists

1993 • 457 citations

Biological properties of interleukin 10

1992 • 359 citations

Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction.

1993 • 322 citations

Lymphocyte Phytohemagglutinin Responsiveness, Immunoglobulins and Autoantibodies in Aging Humans

1973 • 286 citations

Neutrophils degrade subendothelial matrices in the presence of alpha-1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites.

1984 • 253 citations

Differential age-change in the numbers of CD4+CD45RA+ DC4+CD29+ T cell subsets in human peripheral blood

1992 • 239 citations

Continuous anti-interleukin 10 antibody administration depletes mice of Ly-1 B cells but not conventional B cells.

1992 • 197 citations

Effect of aging alone on mechanical properties of the normal adult human lung

1977 • 189 citations

Immunolocalization of elastase in human emphysematous lungs.

1986 • 185 citations

Impaired Delayed Hypersensitivity in an Aging Population

1968 • 183 citations

Immunological responses of healthy elderly population.

1982 • 177 citations

Age, Thymic Involution, and Circulating Thymic Hormone Activity*

1978 • 162 citations

Evaluation of monoclonal gammopathies in the “well” elderly

1987 • 134 citations

STUDIES ON THE COLLAGEN AND ELASTIN CONTENT OF THE HUMAN LUNG*†

1960 • 132 citations

Pericellular proteolysis by neutrophils in the presence of proteinase inhibitors: effects of substrate opsonization.

1988 • 128 citations

The Antibody Responses to Pneumococcal Capsular Polysaccharides in Aged Individuals

1980 • 117 citations

Bronchoalveolar Lavage Cellularity: The Distribution in Normal Volunteers

1992 • 115 citations

Autoimmunity-Prone B-L (Cd5 B) Cells, Natural Antibodies and Self Recognition

1993 • 77 citations

Inhibition of Human Leukocyte Elastase Bound to Elastin: Relative Ineffectiveness and Two Mechanisms of Inhibitory Activity

1990 • 63 citations

Subpopulations of mononuclear cells in ageing: expansion of the null cell compartment and decrease in the number of T and B cells in human blood.

1985 • 63 citations

Unusual pattern of surface marker expression on peripheral lymphocytes from aged humans suggestive of a population of less differentiated cells.

1983 • 57 citations

Altered immune status in the elderly.

1990 • 56 citations

Atypical Manifestations of Pneumonia in the Elderly

1991 • 54 citations

Studies of peritoneal macrophage function in mice with systemic lupus erythematosus: Depressed phagocytosis of opsonized sheep erythrocytes in vitro

1983 • 42 citations

Ductectasia; An Asymptomatic Pulmonary Change Related to Age

1965 • 41 citations

Altered Epithelial Lining Fluid Parameters in Old Normal Individuals

1992 • 38 citations

Lung diffusing capacity. Normal values in male smokers and non-smokers using the breath-holding technique.

1970 • 34 citations

Cellular basis for the age-associated increase in autoimmune reactions

1990 • 31 citations

Autoimmune abnormalities in a murine model of accelerated senescence.

1989 • 29 citations

Alveolar Macrophage Surface Carbohydrate Expression Is Altered in Interstitial Lung Disease as Determined by Lectin-binding Profiles

1993 • 17 citations

The Cellular Basis of Impaired T Lymphocyte Functions in the Elderly

1980 • 17 citations

Priming of Human Alveolar Macrophages and Blood Monocytes for Superoxide Anion Release by Interferons and Lipopolysaccharide

1991 • 11 citations

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