Interleukin-12 release by mitogen-stimulated mononuclear cells in the elderly

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

The Adjuvant Effect of Interleukin-12 in a Vaccine Against Leishmania major

1994 • 687 citations

Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand

1995 • 476 citations

Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction

1995 • 427 citations

Biology of human TH1 and TH2 cells

1995 • 408 citations

Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells.

1994 • 367 citations

Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion.

1996 • 349 citations

Regulation of human cytolytic lymphocyte responses by interleukin-12

1992 • 331 citations

The Cellular and Subcellular Bases of Immunosenescence

1989 • 326 citations

Mechanisms of IFN-gamma induction by natural killer cell stimulatory factor (NKSF/IL-12). Role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2.

1992 • 284 citations

Pgp‐1^hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A

1989 • 279 citations

A soluble form of TRAP (CD40 ligand) is rapidly released after T cell activation

1995 • 252 citations

Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids.

1995 • 215 citations

CD40/CD40 ligand interactions are required for T cell‐dependent production of interleukin‐12 by mouse macrophages

1996 • 184 citations

Human dendritic cells activate T lymphocytes via a CD40: CD40 ligand‐dependent pathway

1996 • 149 citations

Cytokine production pathway in the elderly

1996 • 138 citations

Accessory signaling by CD40 for T cell activation: induction of Th1 and Th2 cytokines and synergy with interleukin‐12 for interferon‐γ production

1996 • 126 citations

Age-related effects in T cell activation and proliferation

1993 • 124 citations

Age-Related Decreases in IL-2 Production by Human T Cells Are Associated with Impaired Activation of Nuclear Transcriptional Factors AP-1 and NF-AT

1996 • 119 citations

The T cell in the ageing individual1This article is based on a presentation to the First International Conference on Aging and Immunology, Bethesda, MD, 16–19 June, 1996.1

1997 • 111 citations

Differential roles for IL-12 in the maintenance of immune responses in infectious versus autoimmune disease.

1996 • 98 citations

Evidence of enhanced type 2 immune response and impaired upregulation of a type 1 response in frail elderly nursing home residents

1997 • 88 citations

Regulation of apoptosis in immune cells

1995 • 72 citations

lnterleukin-12

1995 • 72 citations

Age‐related increase of CD45RO⁺ lymphocytes in physically active adults

1993 • 65 citations

γ-Interferon, Interleukin-4 and Interleukin-6 In Vitro Production in Old Subjects

1993 • 64 citations

Molecular and cell biological studies of ageing and their application to considerations of T lymphocyte immunosenescence

1995 • 63 citations

Cell proliferation and cytokine production by CD4⁺ cells from old mice

1991 • 61 citations

Impairment of signal transduction in T cells from old mice

1997 • 58 citations

The effect of age on mitogen responsive T cell precursors in human beings is completely restored by interleukin-2

1992 • 43 citations

In vitro T cell activation in elderly individuals: failure in CD69 and CD71 expression

1996 • 34 citations

Differential effects of viable and killed bacteria on IL-12 expression of macrophages.

1996 • 33 citations

Induction and Regulation of NFκB during Aging: Role of Protein Kinases

1996 • 26 citations

Soluble interleukin-2 receptor release defect in vitro in elderly subjects

1991 • 23 citations

Different accessory function for T_H1 cells of bone marrow derived macrophages cultured in granulocyte macrophage colony stimulating factor or macrophage colony stimulating factor

1992 • 18 citations