Changes in Telomerase Activity and Telomere Length during Human T Lymphocyte Senescence

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Identification of a specific telomere terminal transferase activity in tetrahymena extracts

1985 • 3,331 citations

A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.

1988 • 2,281 citations

The RNA Component of Human Telomerase

1995 • 2,243 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

A theory of marginotomy

1973 • 1,770 citations

Telomere reduction in human colorectal carcinoma and with ageing

1990 • 1,672 citations

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

1989 • 1,607 citations

The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

1989 • 1,509 citations

A mutant with a defect in telomere elongation leads to senescence in yeast

1989 • 905 citations

Activation of telomerase in human lymphocytes and hematopoietic progenitor cells.

1995 • 871 citations

Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

1995 • 849 citations

Telomerase activity in normal and malignant hematopoietic cells.

1995 • 748 citations

Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.

1993 • 743 citations

Oxidative DNA damage and senescence of human diploid fibroblast cells.

1995 • 697 citations

Telomerase activity in normal leukocytes and in hematologic malignancies

1995 • 619 citations

Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity

1995 • 490 citations

In vivo loss of telomeric repeats with age in humans

1991 • 469 citations

Regulated expression of telomerase activity in human T lymphocyte development and activation.

1996 • 416 citations

Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts.

1996 • 378 citations

Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes

1994 • 360 citations

Regulation of Telomerase Activity in Immortal Cell Lines

1996 • 360 citations

Accelerated telomere shortening in ataxia telangiectasia

1996 • 334 citations

Cell cycle-dependent modulation of telomerase activity in tumor cells.

1996 • 226 citations

Telomerase regulation during entry into the cell cycle in normal human T cells.

1996 • 206 citations

Human T lymphocytes possess a limited in vitro life span

1989 • 121 citations

TEL2, an Essential Gene Required for Telomere Length Regulation and Telomere Position Effect in Saccharomyces cerevisiae

1996 • 96 citations

Telomerase Activity Is Induced by the Stimulation to Antigen Receptor in Human Peripheral Lymphocytes

1996 • 83 citations

In Vitro Cellular Aging in T-Lymphocyte Cultures: Analysis of DNA Content and Cell Size

1993 • 39 citations

Increase in expression levels of interferon-inducible genes in senescent human diploid fibroblasts and in SV40-transformed human fibroblasts with extended lifespan.

1995 • 37 citations

Extension of lifespan of human T lymphocytes by transfection with SV40 large T antigen

1992 • 7 citations

Maintenance of Normal T Lymphocyte Function after Transfection with SV40 Large T

1993 • 4 citations