Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Identification of a specific telomere terminal transferase activity in tetrahymena extracts

1985 • 3,331 citations

A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.

1988 • 2,281 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

Telomere reduction in human colorectal carcinoma and with ageing

1990 • 1,672 citations

Origin of Concatemeric T7DNA

1972 • 1,591 citations

The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

1989 • 1,509 citations

Telomere loss: mitotic clock or genetic time bomb?

1991 • 1,144 citations

Telomere end-replication problem and cell aging

1992 • 1,044 citations

A mutant with a defect in telomere elongation leads to senescence in yeast

1989 • 905 citations

THE MOLECULAR STRUCTURE OF CENTROMERES AND TELOMERES

1984 • 693 citations

[Principle of marginotomy in template synthesis of polynucleotides].

1971 • 566 citations

RAP1 protein interacts with yeast telomeres in vivo: Overproduction alters telomere structure and decreases chromosome stability

1990 • 436 citations

Human telomeres contain at least three types of G–rich repeat distributed non-randomly

1989 • 374 citations

The Cellular and Subcellular Bases of Immunosenescence

1989 • 326 citations

Genetic syndromes in man with potential relevance to the pathobiology of aging.

1978 • 290 citations

Defining cellular senescence in IMR-90 cells: a flow cytometric analysis.

1988 • 196 citations

ANEUPLOIDY IN THE DEGENERATIVE PHASE OF SERIAL CULTIVATION OF HUMAN CELL STRAINS

1963 • 193 citations

Immunology of Down syndrome: A review

2005 • 179 citations

Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos.

1976 • 166 citations

Purification of human T and B cells by a discontinuous density gradient of percoll

1979 • 122 citations

Age-related expansion of functionally inefficient cells with markers of natural killer activity in Down's syndrome

1991 • 110 citations

Chromosomal aberration and sister-chromatid exchange frequencies in peripheral blood lymphocytes of a large human population sample II. Extension of age range

1989 • 104 citations

Isolation of large numbers of fully viable human neutrophils: a preparative technique using percoll density gradient centrifugation.

1982 • 87 citations

T-Cell Function in Aging: Mechanisms of Decline

1991 • 86 citations

Aging, Longevity, and Cancer: Studies in Down's Syndrome and Centenarians^a

1991 • 52 citations

Trisomy 21 (Down's syndrome): Autoimmunity, aging and monoclonal antibody-defined T-cell abnormalities

1989 • 35 citations