Increase of interleukin 6 and decrease of interleukin 2 production during the ageing process are influenced by the health status

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

<scp>gp</scp>130 AND THE INTERLEUKIN-6 FAMILY OF CYTOKINES

1997 • 1,468 citations

Admission criteria for immunogerontological studies in man: The senieur protocol

1984 • 754 citations

Increased cytokine production in mononuclear cells of healthy elderly people

1993 • 648 citations

Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines.

1990 • 642 citations

IgG1 plasmacytosis in interleukin 6 transgenic mice.

1989 • 597 citations

Corticotropin-Releasing Activity of Monokines

1985 • 500 citations

Increase of plasma IL-6 concentration with age in healthy subjects

1992 • 393 citations

Interleukin-6 and interleukin-8 protein and gene expression in human arterial atherosclerotic wall

1996 • 336 citations

Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction.

1993 • 322 citations

Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6

1992 • 299 citations

Endotoxin, tumor necrosis factor-α and interleukin 1 induce interleukin 6 production in vivo

1989 • 298 citations

Thyroid and other organ-specific autoantibodies in healthy ceritenarians

1992 • 223 citations

Interleukin-6 and selected plasma proteins in healthy persons of different ages

1994 • 176 citations

Immune dysregulation in the aging human lung.

1996 • 173 citations

Immunoglobulin patterns in humans over 95 years of age.

1975 • 148 citations

The biological effects of interleukin 6

1996 • 142 citations

Age-related effects in T cell activation and proliferation

1993 • 124 citations

Age-Related Decreases in IL-2 Production by Human T Cells Are Associated with Impaired Activation of Nuclear Transcriptional Factors AP-1 and NF-AT

1996 • 119 citations

Human recombinant IL-6/B cell stimulatory factor 2 augments murine antigen-specific antibody responses in vitro and in vivo.

1988 • 110 citations

Changes in Lymphocyte Subsets, Interleukin 2, and Soluble Interleukin 2 Receptor in Old and Very Old Age

1996 • 110 citations

Cancer in the aged. An epidemiologic perspective on treatment issues

1991 • 100 citations

Increased production of tumor necrosis factor and interleukin-6 by arterial wall of aged rats

1995 • 93 citations

Evidence for Lowered Induction of Nuclear Factor Kappa B in Activated Human T Lymphocytes during Aging

1996 • 79 citations

Aging and Immunity

1992 • 70 citations

Interleukin 2, interleukin 2 receptor, and interferon-γ synthesis and mRNA expression in phorbol myristate acetate and calcium lonophore A23187-stimulated T cells from elderly humans

1989 • 69 citations

Contribution of IL-6 to the antiproliferative effect of IL-1 and tumor necrosis factor on tumor cell lines.

1989 • 62 citations

Immune Response of Elderly Adults to Pneumococcus: Variation by Age, Sex, and Functional Impairment

1987 • 58 citations

Influence of Age on Human Marrow

1995 • 47 citations

Secretion of interleukin-6 (IL-6) by human monocytes stimulated by muramyl dipeptide and tumour necrosis factor alpha.

1990 • 46 citations

Comparison of the effect of IL-2 and IL-6 on the lytic activity of purified human peripheral blood large granular lymphocytes.

1991 • 39 citations

Age-related changes of expression of IL-2 receptor subunits and kinetics of IL-2 internalization in T cells after mitogenic stimulation

1988 • 34 citations

Synergism of interleukin 6 and 1α,25-dihydroxyvitamin D3 in induction of myeloid differentiation of human leukemic cell lines

1992 • 31 citations

Aging and lymphokine production by t cell subsets

1993 • 29 citations

CANCER IN THE AGED

1964 • 27 citations

Ageing and the immune response — A unifying hypothesis?

1984 • 26 citations

Nutritional Status of Centenarians Assessed by Activity and Anthropometric, Hematological and Biochemical Characteristics.

1997 • 24 citations

Mucosal Cytokine Production in Small-Intestinal Bacterial Overgrowth

1996 • 24 citations

Interleukin-6 is constitutively produced by human CTL clones and is required to maintain their cytolytic function

1991 • 23 citations

Soluble interleukin-2 receptor release defect in vitro in elderly subjects

1991 • 23 citations

Recombinant interferons or interleukin-2 increase cytotoxicity by human monocytes and NK cells.

1987 • 22 citations

The influence of recombinant human interleukin-6 on blood and immune parameters in middle-aged and old rhesus monkeys.

1993 • 22 citations

Increased spontaneous secretion of IL-6 from B cells of patients with B chronic lymphatic leukaemia (B-CLL) and autoimmunity

1991 • 21 citations

Interleukin-6 autoantibodies: possible biological and clinical significance.

1995 • 21 citations

Overactivity of Tumor Necrosis Factor-Alpha but Not Interleukin 6 Is Associated with Low Natural Killer Cytotoxic Activity in the Elderly

1997 • 20 citations

Effects of endotoxin on immunity in aging mice

1982 • 15 citations

Accessory cell-derived helper signals in human T-cell activation with phytohemagglutinin: Induction of interleukin 2, responsiveness of interleukin 6, and production of interleukin 2 by interleukin 1

1990 • 14 citations