T-cell regeneration: all repertoires are not created equal

Bone Marrow Transplant

1990 • 2,745 citations

Bone marrow transplant

1999 • 2,452 citations

IMMUNOLOGICAL FUNCTION OF THE THYMUS

1961 • 1,359 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

Age, Thymopoiesis, and CD4+ T-Lymphocyte Regeneration after Intensive Chemotherapy

1995 • 1,066 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

CD8 naive T cell counts decrease progressively in HIV-infected adults.

1995 • 495 citations

The kinetics of immune reconstitution after human marrow transplantation

1987 • 428 citations

Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing.

1996 • 418 citations

Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping: correlation with immune status

1995 • 400 citations

Interconversion of CD45R subsets of CD4 T cells in vivo

1990 • 371 citations

Lymphocyte depletion during treatment with intensive chemotherapy for cancer

1994 • 356 citations

Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo

1989 • 351 citations

Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. Correlation with immune status.

1994 • 345 citations

Lymphocyte depletion during treatment with intensive chemotherapy for cancer

1994 • 314 citations

Clonal predominance of T cell receptors within the CD8+ CD45RO+ subset in normal human subjects.

1993 • 298 citations

T-cell regeneration after bone marrow transplantation: differential CD45 isoform expression on thymic-derived versus thymic-independent progeny

1993 • 293 citations

Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse.

1993 • 265 citations

T cell reconstitution after bone marrow transplantation into adult patients does not resemble T cell development in early life.

1995 • 259 citations

T-cell regeneration after bone marrow transplantation: differential CD45 isoform expression on thymic-derived versus thymic-independent progeny

1993 • 250 citations

Analysis of T-cell repopulation after allogeneic bone marrow transplantation: significant differences between recipients of T-cell depleted and unmanipulated grafts

1996 • 231 citations

Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance.

1995 • 225 citations

The development of cellular immunity to Epstein-Barr virus after allogeneic bone marrow transplantation

1996 • 212 citations

Evidence for extrathymic generation of intermediate T cell receptor cells in the liver revealed in thymectomized, irradiated mice subjected to bone marrow transplantation.

1995 • 194 citations

The peripheral T cell repertoire: independent homeostatic regulation of virgin and activated CD8⁺ T cell pools

1995 • 174 citations

The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells.

1987 • 173 citations

The extrathymic T-cell development pathway

1992 • 169 citations

Altered representation of naive and memory CD8 T cell subsets in HIV-infected children.

1995 • 160 citations

The effect of thymic function on immunocompetence following bone marrow transplantation.

1995 • 155 citations

CD34+ marrow cells, devoid of T and B lymphocytes, reconstitute stable lymphopoiesis and myelopoiesis in lethally irradiated allogeneic baboons

1992 • 144 citations

Differentiation and functional maturation of bone marrow-derived intestinal epithelial T cells expressing membrane T cell receptor in athymic radiation chimeras.

1990 • 144 citations

Oligoclonal expansion of CD8+ CD57+ T cells with restricted T-cell receptor beta chain variability after bone marrow transplantation

1994 • 141 citations

Progress in bone marrow transplantation

1987 • 134 citations

Extrathymic development of V alpha 14-positive T cells.

1993 • 132 citations

Different use of T cell receptor transducing modules in two populations of gut intraepithelial lymphocytes are related to distinct pathways of T cell differentiation.

1994 • 120 citations

Severe lymphocytopenia and interstitial pneumonia in patients treated with paclitaxel and simultaneous radiotherapy for non-small-cell lung cancer.

1996 • 119 citations

Treatment of refractory rheumatoid arthritis with a chimeric ANTI‐CD4 monoclonal antibody

1994 • 118 citations

On the immunocompetence of H-2 incompatible irradiation bone marrow chimeras.

1980 • 118 citations

Definition of the thymic generative lineage by selective expression of high molecular weight isoforms of CD45 (T200)

1989 • 108 citations

In vitro regulation of immunoglobulin synthesis after marrow transplantation. I. T-cell and B-cell deficiencies in patients with and without chronic graft-versus-host disease

1981 • 106 citations

T cell repopulation from functionally restricted splenic progenitors: 10,000-fold expansion documented by using limiting dilution analyses.

1984 • 105 citations

A soluble factor released by CD8+CD57+ lymphocytes from bone marrow transplanted patients inhibits cell-mediated cytolysis

1991 • 99 citations

Emergence of oligoclonal t cell populations following therapeutic t cell depletion in rheumatoid arthritis

1995 • 97 citations

CD4+CD7-CD57+ T cells: a new T-lymphocyte subset expanded during human immunodeficiency virus infection

1992 • 90 citations

Extrathymic maturation of alpha beta T cells from hemopoietic stem cells.

1995 • 90 citations

Analysis of recent thymic emigrants with subse- and maturity-related markers

1990 • 83 citations

Reconstitution of T-cell function after CD6-depleted allogeneic bone marrow transplantation

1990 • 79 citations

Recovery of T cell subsets after autologous bone marrow transplantation is mainly due to proliferation of mature T cells in the graft

1985 • 73 citations

Stable clonal expansion of T cells induced by bone marrow transplantation

1996 • 70 citations

T cell regeneration after allogeneic bone marrow transplantation.

1983 • 69 citations

In vitro regulation of immunoglobulin synthesis by T-cell subpopulations defined by a new human T-cell antigen (9.3)

1982 • 65 citations

Reconstitution of T-cell function after CD6-depleted allogeneic bone marrow transplantation

1990 • 62 citations

The role of thymus in the aging of T_h cell subpopulations and age-associated alteration of cytokine production by these cells

1995 • 60 citations

Regeneration of functional and activated NK and T sub-subset cells in the marrow and blood after autologous bone marrow transplantation: a prospective phenotypic study with 2/3-color FACS analysis.

1989 • 60 citations

Cellular interactions in marrow-grafted patients. I. Impairment of cell-mediated lympholysis associated with graft-vs-host disease and the effect of interleukin 2.

1983 • 57 citations

The reappearance of 10 differentiation antigens on peripheral blood lymphocytes after allogeneic bone marrow transplantation.

1991 • 57 citations

T lymphocyte ontogeny in adenosine deaminase-deficient severe combined immune deficiency after treatment with polyethylene glycol-modified adenosine deaminase.

1993 • 56 citations

The regulation of Ig synthesis after marrow transplantation. IV. T4 and T8 subset function in patients with chronic graft-vs-host disease.

1982 • 54 citations

Inhibiton of IL 2 production after human allogeneic bone marrow transplantation.

1983 • 53 citations

Population kinetics of precursors of IL 2-producing peripheral T lymphocytes: evidence for short life expectancy, continuous renewal, and post-thymic expansion.

1987 • 53 citations

CELLULAR INTERACTIONS IN MARROW-GRAFTED PATIENTS

1985 • 50 citations

Interleukin-2 production and response to interleukin-2 by peripheral blood mononuclear cells from patients after bone marrow transplantation: II. Patients receiving soybean lectin-separated and T cell-depleted bone marrow

1987 • 50 citations

Alterations of T cell repertoire after bone marrow transplantation: characterization of over-represented subsets.

1995 • 45 citations

Human bone marrow allograft recipients: production of, and responsiveness to, interleukin 2.

1983 • 45 citations

The regulation of immunoglobulin synthesis after HLA-identical bone marrow transplantation: VI. Differential rates of maturation of distinct functional groups within lymphoid subpopulations in patients after human marrow grafting

1985 • 45 citations

The thymus in patients with allogeneic bone marrow transplants.

1978 • 44 citations

Characterization of V_β‐bearing cells in athymic (nu/nu) mice suggests an extrathymic pathway for T cell differentiation

1990 • 41 citations

Lymphokine profile in bone marrow transplant recipients

1991 • 33 citations

Marked increase of CD8+S6F1+ and CD8+CD57+ cells in patients with graft-versus-host disease after allogeneic bone marrow transplantation.

1994 • 27 citations

Cellular interactions in marrow-grafted patients. II. Normal monocyte antigen-presenting and defective T-cell-proliferative functions early after grafting and during chronic graft-versus-host disease.

1984 • 25 citations

Failure of T cell receptor-anti-CD3 monoclonal antibody interaction in T cells from marrow recipients to induce increases in intracellular ionized calcium.

1990 • 24 citations

Lymphokine profile in bone marrow transplant recipients

1991 • 21 citations

CELLULAR INTERACTIONS IN MARROW-GRAFTED PATIENTS

1984 • 16 citations

Fidelity of the repertoire in T cell reconstituted athymic nude rats. Preservation of a deficit in alloresponsiveness over one year.

1989 • 15 citations

CARDIAC ALLOGRAFT SURVIVAL ACROSS MAJOR HISTOCOMPATIBILITY COMPLEX BARRIERS IN THE RHESUS MONKEY FOLLOWING T LYMPHOCYTE-DEPLETED AUTOLOGOUS MARROW TRANSPLANTATION

1989 • 11 citations