An antibody specific for interleukin‐6 reverses age‐associated changes in spontaneous and induced cytokine production in mice

Lymphocyte responses and cytokines

1994 • 1,860 citations

The Aging Immune System: Primer and Prospectus

1996 • 1,166 citations

Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells

1997 • 823 citations

Cytokines and macrophages

1994 • 442 citations

Role of cytokines in determining T-lymphocyte function

1994 • 396 citations

Patterns of cytokine gene expression by CD4+ T cells from young and old mice.

1993 • 357 citations

Pgp‐1^hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A

1989 • 279 citations

Dysregulation between TH1 and TH2 T cell subpopulations in the elderly

1996 • 178 citations

The age-associated increase in IFN-gamma synthesis by mouse CD8+ T cells correlates with shifts in the frequencies of cell subsets defined by membrane CD44, CD45RB, 3G11, and MEL-14 expression.

1993 • 168 citations

Cytokine production pathway in the elderly

1996 • 138 citations

Induction of cytokines by zinc ions in human peripheral blood mononuclear cells and separated monocytes.

1994 • 131 citations

Polymorphism of age‐related changes in interleukin (IL) production: differential changes of T helper subpopulations, synthesizing IL 2, IL3 and IL4

1990 • 130 citations

Aged T cells are hyporesponsive to costimulation mediated by CD28.

1994 • 116 citations

Dehydroepiandrosterone and Diseases of Aging

1996 • 102 citations

Investigations of the lymphokine system in elderly individuals

1993 • 98 citations

Age-Related Reductions in the Activation of Mitogen-Activated Protein Kinases p44mapk/ERK1 and p42mapk/ERK2 in Human T Cells Stimulated via Ligation of the T Cell Receptor Complex

1996 • 94 citations

Dysregulation of IL-10 production with aging: Possible linkage to the age-associated decline in DHEA and its sulfated derivative

1996 • 87 citations

Age‐associated changes in mitogen‐induced protein phosphorylation in murine T lymphocytes

1992 • 82 citations

T Lymphocytes and Aging

1995 • 74 citations

lnterleukin-12

1995 • 72 citations

T-Cell Subsets: Who does the polarizing?

1995 • 65 citations

Influence of age on the signal transduction of T cells in mice

1993 • 60 citations

Anti‐CD3‐Induced Apoptosis in T‐Cells From Young and Old Mice

1995 • 46 citations

Evidence for a Defective Accumulation of Protective T Cells in Old Mice Infected with Mycobacterium tuberculosis

1993 • 42 citations

Age‐related changes in salivary antibodies to commensal oral and gut biota

1997 • 41 citations

Differential production of IL-12 in BALB/c and DBA/2 mice controls IL-4 versus IFN-γ synthesis in primed CD4 lymphocytes

1996 • 37 citations

Secretion of cytokines upon allogeneic stimulation: effect of aging.

1994 • 23 citations

Age-related changes in interleukin production in BALB/cNNia and SJL/J mice and their modification after administration of foreign macromolecules

1993 • 20 citations

[Role of oxidative stress in aging].

1996 • 5 citations

[Molecular mechanisms of age-related lymphocyte dysfunction].

1996 • 5 citations