Oligoclonality of CD8 + T cells in health and disease: Aging, infection, or immune regulation?

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

Telomere loss: mitotic clock or genetic time bomb?

1991 • 1,144 citations

Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy".

1994 • 788 citations

Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.

1993 • 743 citations

Genetic determination of telomere size in humans: a twin study of three age groups.

1994 • 738 citations

The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments.

1993 • 664 citations

Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts.

1996 • 378 citations

Decline in CD28+ T cells in centenarians and in long-term T cell cultures: A possible cause for both in vivo and in vitro immunosenescence

1994 • 375 citations

Clonal predominance of T cell receptors within the CD8+ CD45RO+ subset in normal human subjects.

1993 • 298 citations

Analysis of clonal CD8+ T cell expansions in normal individuals and patients with rheumatoid arthritis.

1995 • 213 citations

Murine CD8+ T cells that specifically delete autologous CD4+ T cells expressing Vβ8 TCR: a role of the Qa-1 molecule

1995 • 175 citations

Oligoclonal CD8+ T cells are preferentially expanded in the CD57+ subset.

1995 • 162 citations

CD8highCD57+ T lymphocytes in normal, healthy individuals are oligoclonal and respond to human cytomegalovirus.

1995 • 160 citations

Human lymphocyte subpopulations identified by using three-color immunofluorescence and flow cytometry analysis: correlation of Leu-2, Leu-3, Leu-7, Leu-8, and Leu-11 cell surface antigen expression.

1984 • 159 citations

Clonal V alpha 12.1+ T cell expansions in the peripheral blood of rheumatoid arthritis patients.

1993 • 119 citations

Subsets of CD8+, CD57+ cells in normal, healthy individuals: correlations with human cytomegalovirus (HCMV) carrier status, phenotypic and functional analyses

1993 • 111 citations

Persistence of T8+/HNK-1+ suppressor lymphocytes in the blood of long-term surviving patients after allogeneic bone marrow transplantation.

1986 • 105 citations

Oligoclonality of V beta 3 TCR chains in the CD8+ T cell population of rheumatoid arthritis patients.

1996 • 95 citations

Presence of clonal T cell populations in chronic B lymphocytic leukemia and smoldering myeloma.

1990 • 93 citations

Benign Monoclonal Gammopathy

1982 • 93 citations

CD8 lymphocytosis in primary cytomegalovirus (CMV) infection of allograft recipients: expansion of an uncommon CD8+ CD57− subset and its progressive replacement by CD8+CD57+ T cells

1994 • 89 citations

The expanded null cell compartment in ageing: increase in the number of natural killer cells and changes in T-cell and NK-cell subsets in human blood.

1986 • 89 citations

Oligoclonality in the Human CD8+ T Cell Repertoire in Normal Subjects and Monozygotic Twins: Implications for Studies of Infectious and Autoimmune Diseases

1995 • 82 citations

A lectin‐binding soluble factor released by CD8⁺CD57⁺ lymphocytes from AIDS patients inhibits T cell cytotoxicity

1991 • 81 citations

Suppression of Immunoglobulin Synthesis by Lymphocyte Subpopulations in Patients With Crohn's Disease

1984 • 72 citations

Human CD8+ T lymphocyte clones specific for T cell receptor Vβ families expressed on autologous CD4+ T cells

1995 • 69 citations

A persistent T cell expansion in the peripheral blood of a normal adult male: a new clinical entity?

1992 • 57 citations

Abnormality of Leu 2+7+ cells in acquired immune deficiency syndrome (AIDS), AIDS-related complex, and asymptomatic homosexuals

1986 • 54 citations

Oligoclonality of CD8 + T cells in Multiple Sclerosis

1996 • 47 citations

CD8^high(CD57⁺) T cells in normal, healthy individuals specifically suppress the generation of cytotoxic T lymphocytes to Epstein‐Barr virus‐transformed B cell lines

1994 • 47 citations

T cell antigen receptors in autoimmunity.

1988 • 46 citations

Apoptosis of activated CD8+/CD57+ T cells is induced by some combinations of anti-CD2 mAb.

1993 • 42 citations

HNK-1+ (Leu-7) and other lymphocyte subsets in long-term survivors with renal allotransplants.

1985 • 40 citations

Role of CD2 in activation and cytotoxic function of CD8/Leu-7-positive T cells.

1988 • 29 citations

Induction of cytolytic function in resting peripheral blood CD8+/ Leu-7+ T cells through IL2/p 75 IL2-receptor interaction: A study in the allogeneic human bone marrow transplantation model

1990 • 9 citations