Thymocyte progenitors and T cell development in aging

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

The aging of hematopoietic stem cells

1996 • 850 citations

Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.

1993 • 743 citations

Human naive and memory T lymphocytes differ in telomeric length and replicative potential.

1995 • 424 citations

Aging and Immune Function

1991 • 361 citations

Effect of deoxyguanosine on lymphopoiesis in the developing thymus rudiment in vitro: Application in the production of chimeric thymus rudiments

1982 • 324 citations

Pgp‐1^hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A

1989 • 279 citations

Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice.

1990 • 264 citations

Reentry of T cells to the adult thymus is restricted to activated T cells.

1991 • 263 citations

Lineage relationships and developmental kinetics of immature thymocytes: CD3, CD4, and CD8 acquisition in vivo and in vitro.

1990 • 143 citations

Age-associated decline in precursor frequency for different T cell-mediated reactions, with preservation of helper or cytotoxic effect per precursor cell.

1984 • 140 citations

Polymorphism of age‐related changes in interleukin (IL) production: differential changes of T helper subpopulations, synthesizing IL 2, IL3 and IL4

1990 • 130 citations

Immunologic studies of aging. V. Impaired proliferation of PHA responsive human lymphocytes in culture.

1980 • 116 citations

The pattern of T lymphocyte differentiation is altered during thymic involution

1995 • 110 citations

Increased function of P-glycoprotein in T lymphocyte subsets of aging mice.

1993 • 99 citations

Cellular aspects of early T-cell development

1992 • 91 citations

Rare peripheral T cells migrate to and persist in normal mouse thymus.

1988 • 86 citations

Stimulation of murine T cell subsets with anti-CD3 antibody. Age-related defects in the expression of early activation molecules.

1989 • 85 citations

T Lymphocytes and Aging

1995 • 74 citations

Age-related changes in the capacity of bone marrow cells to differentiate in thymic organ cultures

1988 • 64 citations

Cell proliferation and cytokine production by CD4⁺ cells from old mice

1991 • 61 citations

In vitro analysis of age‐related changes in the developmental potential of bone marrow thymocyte progenitors

1990 • 60 citations

Age influence on the thymic capacity to promote differentiation of T cells: Induction of different composition of T cell subsets by aging thymus

1991 • 60 citations

Limiting dilution analysis of alloreactive cytotoxic precursor cells in aging mice.

1983 • 59 citations

Influence of age of thymic grafts on the differentiation of T cells in nude mice

1982 • 57 citations

Immunohistological analysis of immigration of thymocyte-precursors into the thymus: Evidence for immigration of peripheral T cells into the thymic medulla

1989 • 47 citations

Influence of age on the proliferation and peripheralization of thymic T cells.

1988 • 34 citations

Feedback Regulation of T Cell Development in the Thymus

1996 • 33 citations

Cellular immunosenescence: An overview

1991 • 27 citations

A mathematical model of the effect of aging on bone marrow cells colonizing the thymus

1993 • 26 citations

Developmental interactions of CD4 T cells and thymocytes: age-related differential effects

1994 • 23 citations

Migration of peripheral T and B cells into the thymus of aging (NZB × SJL)F1 female mice

1984 • 18 citations

THE EFFECT OF AGING ON CYTOKINE RELEASE AND ASSOCIATED IMMUNOLOGIC FUNCTIONS

1993 • 17 citations

Thymocyte development in an in vitro constructed chimera of irradiated fetal thymus and lymphohemopoietic cells.

1991 • 15 citations

Developmental Changes in Bone Marrow Thymocyte Progenitors and Thy1⁺Cells in Aging

1991 • 11 citations

Differential expression of membrane polypeptides on fetal thymic stroma co-cultured with bone marrow cells from young and old mice

1992 • 11 citations

Effect of thymus grafts of various ages on the immune system formation in CBA mice

1985 • 8 citations

Developmental Aspects of T Lymphocytes in Aging

1990 • 8 citations

Differentiation patterns of CD4CD8 thymocyte subsets in cocultures of fetal thymus and lymphohemopoietic cells from c-fos transgenic and normal mice

1992 • 3 citations