Retrovirus-mediated expression of a DNA repair protein in bone marrow protects hematopoietic cells from nitrosourea-induced toxicity in vitro and in vivo.

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

Selection of Drug-Resistant Bone Marrow Cells in Vivo After Retroviral Transfer of Human MDR 1

1992 • 500 citations

Chemotherapy for malignant gliomas

1988 • 343 citations

DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

1980 • 315 citations

Comparison of O⁶-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues

1986 • 277 citations

Detection of primitive macrophage progenitor cells in mouse bone marrow

1979 • 232 citations

Transfer and expression of the human multiple drug resistance gene into live mice.

1992 • 210 citations

Long-term in vivo expression of a murine adenosine deaminase gene in rhesus monkey hematopoietic cells of multiple lineages after retroviral mediated gene transfer into CD34+ bone marrow cells

1993 • 185 citations

Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow.

1987 • 144 citations

Serial transplantation of methotrexate-resistant bone marrow: protection of murine recipients from drug toxicity by progeny of transduced stem cells

1990 • 141 citations

Effects of recombinant human interleukin-11 on hematopoietic reconstitution in transplant mice: acceleration of recovery of peripheral blood neutrophils and platelets

1993 • 139 citations

Cross-linking of DNA induced by chloroethyinitrosourea is prevented by O⁶-methyiguanine-DNA methyttransferase

1983 • 137 citations

Long-term expression of human adenosine deaminase in mice transplanted with retrovirus-infected hematopoietic stem cells.

1989 • 133 citations

Expression and cloning of complementary DNA for a human enzyme that repairs O6-methylguanine in DNA

1990 • 130 citations

The nitrosoureas: carmustine (BCNU) and lomustine (CCNU)

1982 • 122 citations

Nitrosoureas: a review of experimental antitumor activity.

1976 • 91 citations

Differential effects of cytotoxic agents on hematopoietic progenitors.

1981 • 86 citations

The Role of O6-Methylguanine in Human Cell Killing, Sister Chromatid Exchange Induction and Mutagenesis: A Review

1987 • 78 citations

Retroviral gene transfer of human adenosine deaminase in murine hematopoietic cells: effect of selectable marker sequences on long-term expression

1991 • 77 citations

Effect of O6-alkylguanine pretreatment on the sensitivity of human colon tumor cells to the cytotoxic effects of chloroethylating agents.

1986 • 67 citations

Formation of covalent complexes between humanO⁶alkyltransferase and BCNU-treated defined length synthetic oligodeoxynucleotides

1988 • 56 citations

Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine DNA glycosylase.

1993 • 45 citations

Affinity purification and characterization of humanO⁶-alkylguanine-DNA aikyltransferase complexed with BCNU-treated, synthetic oligonudeotide

1989 • 41 citations

Increased survival and multilineage hematopoietic protection from delayed and severe myelosuppressive effects of a nitrosourea with recombinant interleukin-11.

1994 • 40 citations

Genetic transformation of murine bone marrow cells to methotrexate resistance

1983 • 35 citations