Susceptibility to apoptosis of T lymphocytes from elderly humans is associated with increased in vivo expression of functional Fas receptors

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

"Panning" for lymphocytes: a method for cell selection.

1978 • 1,319 citations

Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.

1992 • 857 citations

Checkpoints of dueling dimers foil death wishes

1994 • 806 citations

Admission criteria for immunogerontological studies in man: The senieur protocol

1984 • 754 citations

Fas and FasL in the homeostatic regulation of immune responses

1995 • 579 citations

Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus.

1994 • 555 citations

Purification and characterization of the Fas-ligand that induces apoptosis.

1994 • 521 citations

Fas transduces activation signals in normal human T lymphocytes.

1993 • 521 citations

Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood.

1992 • 510 citations

The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells

1994 • 457 citations

Role of Ceramide in Cellular Senescence

1995 • 453 citations

Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens.

1992 • 282 citations

Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors.

1988 • 257 citations

Differential age-change in the numbers of CD4+CD45RA+ DC4+CD29+ T cell subsets in human peripheral blood

1992 • 239 citations

Effects of the lpr mutation on elimination and inactivation of self-reactive B cells.

1994 • 156 citations

Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice.

1995 • 151 citations

Age-related defect in signal transduction during lectin activation of murine T lymphocytes.

1987 • 147 citations

Age-Related Decreases in IL-2 Production by Human T Cells Are Associated with Impaired Activation of Nuclear Transcriptional Factors AP-1 and NF-AT

1996 • 119 citations

Involvement of apoptosis antigen Fas in clonal deletion of human thymocytes

1994 • 97 citations

Age-Related Reductions in the Activation of Mitogen-Activated Protein Kinases p44mapk/ERK1 and p42mapk/ERK2 in Human T Cells Stimulated via Ligation of the T Cell Receptor Complex

1996 • 94 citations

Expression and Function of Fas Antigen and bcl-2 in Human Systemic Lupus Erythematosus Lymphocytes

1994 • 93 citations

Excessive apoptosis of mature T lymphocytes is a characteristic feature of human immune senescence

1996 • 78 citations

A comprehensive analysis of peripheral blood lymphocytes in healthy aged humans by flow cytometry

1993 • 72 citations

Age-related tyrosine-specific protein phosphorylation defect in human T lymphocytes activated through CD3, CD4, CD8 or the IL-2 receptor

1996 • 53 citations

Differential Expression of Fas Antigen and Bcl-2 Protein on CD4+ T Cells, CD8+ T Cells, and Monocytes

1995 • 48 citations

Anti‐CD3‐Induced Apoptosis in T‐Cells From Young and Old Mice

1995 • 46 citations

Decreased steady state c-myc mRNA in activated T cell cultures from old humans is caused by a smaller proportion of T cells that transcribe the c-myc gene.

1990 • 44 citations

Physiological T‐Cell Death: Susceptibility is Modulated by Activation, Aging, and Transformation, but the Mechanism is Constant

1994 • 39 citations

Fas Antigen and Sphingomyelin‐Ceramide Turnover‐Mediated Signaling: Role in Life and Death of T Lymphocytes¹

1994 • 37 citations

Restricted expression of mitogen-induced high affinity IL-2 receptors in aging mice.

1988 • 35 citations

Expression of c-fos, c-jun and jun B in peripheral blood lymphocytes from young and elderly adults

1992 • 32 citations

Phytohemagglutinin induced changes of membrane lipid packing , c-myc and c-myb encoded protein expression in human lymphocytes during aging

1992 • 18 citations

Apoptose et sénescence

1995 • 3 citations