Mouse liver T cells: Their change with aging and in comparison with peripheral T cells

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans.

1994 • 1,044 citations

A Subset of CD4 ⁺ Thymocytes Selected by MHC Class I Molecules

1994 • 464 citations

Interferon gamma production by natural killer (NK) cells and NK1.1+ T cells upon NKR-P1 cross-linking.

1996 • 349 citations

Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice.

1994 • 304 citations

Presence of hematopoietic stem cells in the adult liver

1996 • 300 citations

Pgp‐1^hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A

1989 • 279 citations

Clearance of adenovirus-infected hepatocytes by MHC class I-restricted CD4+ CTLs in vivo.

1995 • 269 citations

Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells.

1996 • 268 citations

NK1.1⁺ CD4⁺ CD8‐ thymocytes with specific lymphokine secretion

1993 • 265 citations

Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice.

1990 • 264 citations

Unexpected expansions of CD8-bearing cells in old mice.

1993 • 228 citations

Cytotoxic NK1.1 Ag+ alpha beta T cells with intermediate TCR induced in the liver of mice by IL-12.

1995 • 222 citations

Unusual T cell populations in adult murine bone marrow. Prevalence of CD3+CD4-CD8- and alpha beta TCR+NK1.1+ cells.

1990 • 196 citations

Evidence for extrathymic generation of intermediate T cell receptor cells in the liver revealed in thymectomized, irradiated mice subjected to bone marrow transplantation.

1995 • 194 citations

Relationships between intermediate TCR cells and NK1.1+ T cells in various immune organs. NK1.1+ T cells are present within a population of intermediate TCR cells.

1995 • 179 citations

Liver NK1.1+ CD4+ alpha beta T cells activated by IL-12 as a major effector in inhibition of experimental tumor metastasis.

1996 • 175 citations

Liver is a possible site for the proliferation of abnormal CD3+4-8- double-negative lymphocytes in autoimmune MRL-lpr/lpr mice.

1990 • 173 citations

Details of an isolation method for hepatic lymphocytes in mice

1992 • 169 citations

Positive selection of V beta 8+ CD4-8- thymocytes by class I molecules expressed by hematopoietic cells.

1993 • 165 citations

Class I dependence of the development of CD4+ CD8- NK1.1+ thymocytes.

1994 • 155 citations

Estrogen administration activates extrathymic T cell differentiation in the liver.

1992 • 153 citations

Isolation and flow cytometric analysis of the free lymphomyeloid cells present in murine liver

1990 • 148 citations

Age-related defect in signal transduction during lectin activation of murine T lymphocytes.

1987 • 147 citations

Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells

1995 • 141 citations

Selective expansion of cytotoxic T lymphocytes with a CD4+CD56+ surface phenotype and a T helper type 1 profile of cytokine secretion in the liver of patients chronically infected with Hepatitis B virus.

1994 • 136 citations

LPS induces NK1.1+ alpha beta T cells with potent cytotoxicity in the liver of mice via production of IL-12 from Kupffer cells.

1996 • 132 citations

Age-dependent increase of extrathymic T cells in the liver and their appearance in the periphery of older mice.

1992 • 130 citations

Tolerance-related V beta clonal deletions in normal CD4-8-, TCR-alpha/beta + and abnormal lpr and gld cell populations.

1989 • 127 citations

Unusual alpha beta-T cells expanded in autoimmune lpr mice are probably a counterpart of normal T cells in the liver.

1991 • 124 citations

c-kit+ stem cells and thymocyte precursors in the livers of adult mice.

1996 • 121 citations

Cytotoxic gammadelta or alphabeta T cells with a natural killer cell marker, CD56, induced from human peripheral blood lymphocytes by a combination of IL-12 and IL-2.

1996 • 121 citations

Persistence of T8+/HNK-1+ suppressor lymphocytes in the blood of long-term surviving patients after allogeneic bone marrow transplantation.

1986 • 105 citations

Spontaneous development of organ-specific autoimmune lesions in aged C57BL/6 mice.

1989 • 95 citations

IL-4 producing CD4⁺ TCRα β^int liver lymphocytes: influence of thymus, β₂-microglobulin and NK1.1 expression

1995 • 92 citations

The expanded null cell compartment in ageing: increase in the number of natural killer cells and changes in T-cell and NK-cell subsets in human blood.

1986 • 89 citations

Diminished Calcium Signal Generation in Subsets of T Lymphocytes That Predominate in Old Mice

1990 • 89 citations

Origin of CD57+ T cells which increase at tumour sites in patients with colorectal cancer

1995 • 70 citations

Extrathymic Pathways of T-cell Differentiation in the Liver and Other Organs

1994 • 68 citations

An inhibitor of cytotoxic functions produced by CD8⁺CD57⁺ T lymphocytes from patients suffering from AIDS and immunosuppressed bone marrow recipients

1994 • 65 citations

Age‐related increase of CD45RO⁺ lymphocytes in physically active adults

1993 • 65 citations

Reduced development of CD4⁻8⁻B220⁺ T cells but normal autoantibody production in lpr/lpr mice lacking major histocompatibility complex class I molecules

1995 • 64 citations

Evidence for extrathymic development of TNK cells. NK1+ CD3+ cells responsible for acute marrow graft rejection are present in thymus-deficient mice.

1992 • 64 citations

Extrathymic Differentiation of a T Cell Bearing Invariant Vα14Jα281 TCR

1994 • 46 citations

HNK-1+ (Leu-7) and other lymphocyte subsets in long-term survivors with renal allotransplants.

1985 • 40 citations

Interleukin‐12 induces cytotoxic NK1⁺αβ T cells in the lungs of euthymic and athymic mice

1996 • 37 citations

Thymus‐derived cytokine(s) including interleukin‐7 induce increase of T cell receptor α/β⁺ CD4⁻CD8⁻ T cells which are extrathymically differentiated in athymic nude mice

1993 • 36 citations

Supportive cellular elements for hepatic T cell differentiation: T cells expressing intermediate levels of the T cell receptor are cytotoxic against syngeneic hepatoma, and are lost after hepatocyte damage

1995 • 31 citations

V beta repertoire of murine hepatic T cells. Implication for selection of double negative alpha beta + T cells.

1994 • 24 citations

Vβ Gene Repertoire in the Aging Mouse: A Developmental Perspective

1995 • 15 citations

Precursor cells to CD3‐intermediate (CD3^int) liver mononuclear cells in the adult liver: Further evidence for the extrathymic development of CD3^int liver mononuclear cells

1995 • 14 citations

Development of autoreactivity and changes of T cell repertoire in different strains of aging mice

1995 • 10 citations