Focal Adhesions: A Nexus for Intracellular Signaling and Cytoskeletal Dynamics

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement

1999 • 1,452 citations

Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells

1999 • 1,015 citations

Rac Downregulates Rho Activity

1999 • 840 citations

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

1997 • 772 citations

Bidirectional signaling between the cytoskeleton and integrins

1999 • 765 citations

Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα ₁₃

1998 • 765 citations

Src family kinases are required for integrin but not PDGFR signal transduction

1999 • 733 citations

Integrin signaling and cell growth control

1998 • 655 citations

Interplay between Rac and Rho in the control of substrate contact dynamics

1999 • 623 citations

Integrin-mediated Signals Regulated by Members of the Rho Family of GTPases

1998 • 615 citations

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

1996 • 595 citations

Inhibition of Myosin Light Chain Kinase by p21-Activated Kinase

1999 • 592 citations

Molecular interactions in cell adhesion complexes

1997 • 583 citations

Focal adhesions – the cytoskeletal connection

2000 • 569 citations

P120 Catenin Regulates the Actin Cytoskeleton via Rho Family Gtpases

2000 • 563 citations

Adhesion in cell migration

1995 • 520 citations

ADP-Ribosylation Factor 6 Regulates a Novel Plasma Membrane Recycling Pathway

1997 • 494 citations

Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts

1999 • 491 citations

The Molecular Architecture of Focal Adhesions

1995 • 479 citations

Integrins and Actin Filaments: Reciprocal Regulation of Cell Adhesion and Signaling

2000 • 476 citations

Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.

1994 • 469 citations

Paxillin LD4 Motif Binds PAK and PIX through a Novel 95-kD Ankyrin Repeat, ARF–GAP Protein: A Role in Cytoskeletal Remodeling

1999 • 466 citations

Inhibition of RhoA by p120 catenin

2000 • 459 citations

Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK

2000 • 454 citations

Microtubule Targeting of Substrate Contacts Promotes Their Relaxation and Dissociation

1999 • 452 citations

Molecular diversity of cell-matrix adhesions

1999 • 444 citations

Gα12 and Gα13 Stimulate Rho-dependent Stress Fiber Formation and Focal Adhesion Assembly

1995 • 443 citations

αLβ2 Integrin/LFA-1 Binding to ICAM-1 Induced by Cytohesin-1, a Cytoplasmic Regulatory Molecule

1996 • 439 citations

Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism

2000 • 429 citations

Human Ect2 Is an Exchange Factor for Rho Gtpases, Phosphorylated in G2/M Phases, and Involved in Cytokinesis

1999 • 418 citations

The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases.

1995 • 410 citations

Analysis of receptor signaling pathways by mass spectrometry: Identification of Vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors

2000 • 409 citations

Physical State of the Extracellular Matrix Regulates the Structure and Molecular Composition of Cell-Matrix Adhesions

2000 • 402 citations

Protein-tyrosine Phosphatase Shp-2 Regulates Cell Spreading, Migration, and Focal Adhesion

1998 • 390 citations

Cyk-4

2000 • 386 citations

A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to Rho

1999 • 386 citations

Syndecan-4 signals cooperatively with integrins in a Rhodependent manner in the assembly of focal adhesions and actin stress fibers

1999 • 360 citations

Involvement of microtubules in the control of adhesion-dependent signal transduction

1996 • 358 citations

A New Member of the Rho Family, Rnd1, Promotes Disassembly of Actin Filament Structures and Loss of Cell Adhesion

1998 • 349 citations

Focal Adhesion Motility Revealed in Stationary Fibroblasts

1999 • 345 citations

The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions.

1995 • 329 citations

Targeting, Capture, and Stabilization of Microtubules at Early Focal Adhesions

1998 • 323 citations

Signaling networks linking integrins and Rho family GTPases

2000 • 310 citations

Fibroblast contractility and actin organization are stimulated by microtubule inhibitors

1989 • 303 citations

Cloning and Characterization of GEF-H1, a Microtubule-associated Guanine Nucleotide Exchange Factor for Rac and Rho GTPases

1998 • 296 citations

Oncogenic Ras Downregulates Rac Activity, Which Leads to Increased Rho Activity and Epithelial–Mesenchymal Transition

2000 • 290 citations

The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility

1998 • 290 citations

Protein Tyrosine Phosphatase-PEST Regulates Focal Adhesion Disassembly, Migration, and Cytokinesis in Fibroblasts

1999 • 284 citations

Monocyte Adhesion and Spreading on Human Endothelial Cells Is Dependent on Rho-regulated Receptor Clustering

1999 • 269 citations

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

1998 • 265 citations

Identification of a Novel Human Rho Protein with Unusual Properties: GTPase Deficiency and In Vivo Farnesylation

1996 • 265 citations

Dbl family proteins

1997 • 260 citations

Selective regulation of integrin–cytoskeleton interactions by the tyrosine kinase Src

1999 • 257 citations

Rho Guanosine Triphosphatase Mediates the Selective Stabilization of Microtubules Induced by Lysophosphatidic Acid

1998 • 257 citations

c-Src regulates the simultaneous rearrangement of actin cytoskeleton, p190RhoGAP, and p120RasGAP following epidermal growth factor stimulation.

1995 • 256 citations

Vav2 Is an Activator of Cdc42, Rac1, and RhoA

2000 • 250 citations

ASAP1, a Phospholipid-Dependent Arf GTPase-Activating Protein That Associates with and Is Phosphorylated by Src

1998 • 234 citations

Contraction due to microtubule disruption is associated with increased phosphorylation of myosin regulatory light chain.

1995 • 229 citations

Dynamics of beta 1 integrin-mediated adhesive contacts in motile fibroblasts.

1992 • 222 citations

Microtubule Disruption Induces the Formation of Actin Stress Fibers and Focal Adhesions in Cultured Cells: Possible Involvement of the Rho Signal Cascade.

1996 • 214 citations

The Arf GTPase-activating protein ASAP1 regulates the actin cytoskeleton

2000 • 212 citations

Focal adhesion assembly

1997 • 212 citations

Rhoa Function in Lamellae Formation and Migration Is Regulated by the α6β4 Integrin and Camp Metabolism

2000 • 208 citations

RhoE Regulates Actin Cytoskeleton Organization and Cell Migration

1998 • 208 citations

Caldesmon Inhibits Nonmuscle Cell Contractility and Interferes with the Formation of Focal Adhesions

1999 • 197 citations

Lysophosphatidic acid and microtubule-destabilizing agents stimulate fibronectin matrix assembly through Rho-dependent actin stress fiber formation and cell contraction.

1997 • 197 citations

Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1

1998 • 197 citations

Microtubule Depolymerization Induces Stress Fibers, Focal Adhesions, and DNA Synthesis via the GTP-Binding Protein Rho

1998 • 197 citations

Control of morphology, cytoskeleton and migration by syndecan-4

1999 • 191 citations

Vav2 Activates Rac1, Cdc42, and RhoA Downstream from Growth Factor Receptors but Not β1 Integrins

2000 • 191 citations

Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins.

1996 • 176 citations

Integrin dynamics on the tail region of migrating fibroblasts

1996 • 175 citations

ADP-Ribosylation Factor 6 Regulates Actin Cytoskeleton Remodeling in Coordination with Rac1 and RhoA

2000 • 173 citations

Contact formation during fibroblast locomotion: involvement of membrane ruffles and microtubules.

1988 • 171 citations

Syndecan-4 and integrins: combinatorial signaling in cell adhesion

1999 • 162 citations

Rho-stimulated Contractility Contributes to the Fibroblastic Phenotype of Ras-transformed Epithelial Cells

1997 • 161 citations

GIT Proteins, A Novel Family of Phosphatidylinositol 3,4,5-Trisphosphate-stimulated GTPase-activating Proteins for ARF6

2000 • 153 citations

Vav Family Proteins Couple to Diverse Cell Surface Receptors

2000 • 148 citations

Phosphoinositide 3-OH Kinase Activates the β2Integrin Adhesion Pathway and Induces Membrane Recruitment of Cytohesin-1

1998 • 148 citations

Role of P120 Ras-Gap in Directed Cell Movement

2000 • 148 citations

ARF1 Mediates Paxillin Recruitment to Focal Adhesions and Potentiates Rho-stimulated Stress Fiber Formation in Intact and Permeabilized Swiss 3T3 Fibroblasts

1998 • 143 citations

Tyrosine phosphorylation and cytoskeletal tension regulate the release of fibroblast adhesions.

1995 • 142 citations

Syndecan-4 Deficiency Impairs Focal Adhesion Formation Only under Restricted Conditions

2000 • 134 citations

Requirement for Rho in Integrin Signalling

1997 • 127 citations

Dissociation of FAK/p130CAS/c-Src Complex during Mitosis: Role of Mitosis-specific Serine Phosphorylation of FAK

1999 • 121 citations

A New Paxillin-binding Protein, PAG3/Papα/KIAA0400, Bearing an ADP-Ribosylation Factor GTPase-activating Protein Activity, Is Involved in Paxillin Recruitment to Focal Adhesions and Cell Migration

2000 • 108 citations

Evidence for a Calpeptin-sensitive Protein-tyrosine Phosphatase Upstream of the Small GTPase Rho

1999 • 107 citations

Syndecan-4 core protein is sufficient for the assembly of focal adhesions and actin stress fibers

1999 • 104 citations

Morphological Changes and Detachment of Adherent Cells Induced by p122, a GTPase-activating Protein for Rho

1999 • 101 citations

Cytoskeletal changes induced by GRAF, the <u>G</u>TPase <u>r</u>egulator <u>a</u>ssociated with <u>f</u>ocal adhesion kinase, are mediated by Rho

1999 • 100 citations

RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion

2000 • 98 citations

G13α-mediated PYK2 Activation

2000 • 81 citations

Antibody-induced engagement of beta 2 integrins on adherent human neutrophils triggers activation of p21ras through tyrosine phosphorylation of the protooncogene product Vav.

1996 • 81 citations

Rho‐specific binding and guanine nucleotide exchange catalysis by KIAA0380, a Dbl family member

1999 • 52 citations

The Carboxyl-terminal Tyrosine Residue of Protein-tyrosine Phosphatase α Mediates Association with Focal Adhesion Plaques

2000 • 50 citations

Cross-linking of integrins induces tyrosine phosphorylation of the proto-oncogene product Vav and the protein tyrosine kinase Syk in human factor-dependent myeloid cells.

1997 • 48 citations

Phosphorylation- and Activation-independent Association of the Tyrosine Kinase Syk and the Tyrosine Kinase Substrates Cbl and Vav with Tubulin in B-Cells

1999 • 42 citations

Maturation of Cell-Substratum Focal Adhesions Induced by Depolymerization of Microtubules is Mediated by Increased Cortical Tension

1998 • 41 citations

Integrin-dependent Tyrosine Phosphorylation and Growth Regulation by Vav

1999 • 34 citations

G Protein βγ Subunits Induce Stress Fiber Formation and Focal Adhesion Assembly in a Rho-dependent Manner in HeLa Cells

2000 • 24 citations

Relative frequency of B. coli communior in contaminated water

1912 • 12 citations

Deleted Work

1955 • 0 citations