The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

The Regulation of Rabbit Skeletal Muscle Contraction

1971 • 4,491 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator

1991 • 3,314 citations

Functional interaction of β-catenin with the transcription factor LEF-1

1996 • 2,847 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Association of the APC Tumor Suppressor Protein with Catenins

1993 • 1,202 citations

Morphogenesis of the Polarized Epithelial Cell Phenotype

1989 • 1,087 citations

From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion

1993 • 997 citations

Cadherins in cancer: implications for invasion and metastasis

1993 • 939 citations

Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.

1993 • 912 citations

Synergistic Roles for Receptor Occupancy and Aggregation in Integrin Transmembrane Function

1995 • 900 citations

The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex.

1988 • 810 citations

ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons.

1994 • 790 citations

Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex.

1995 • 739 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 725 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin.

1995 • 651 citations

Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway.

1996 • 601 citations

Regulation of Scatter Factor/Hepatocyte Growth Factor Responses by Ras, Rac, and Rho in MDCK Cells

1995 • 547 citations

Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts.

1992 • 519 citations

Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity

1990 • 444 citations

Tyrosine Phosphorylation of β-Catenin and Plakoglobin Enhanced by Hepatocyte Growth Factor and Epidermal Growth Factor in Human Carcinoma Cells

1994 • 421 citations

Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia.

1995 • 418 citations

The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases.

1995 • 410 citations

Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin

1994 • 405 citations

Signal transduction by β-catenin

1995 • 398 citations

Regulation of receptor-mediated endocytosis by Rho and Rac

1996 • 386 citations

Intracellular localization of the P21rho proteins.

1992 • 382 citations

Role of Actin Polymerization and Adhesion to Extracellular Matrix in Rac- and Rho-induced Cytoskeletal Reorganization

1997 • 378 citations

Regulation of connexin 43-mediated gap junctional intercellular communication by Ca2+ in mouse epidermal cells is controlled by E-cadherin.

1991 • 366 citations

Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo.

1995 • 313 citations

The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions.

1992 • 312 citations

Signal transduction and actin filament organization

1996 • 309 citations

Lateral dimerization is required for the homophilic binding activity of C-cadherin.

1996 • 307 citations

Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia.

1995 • 304 citations

Construction of epithelioid sheets by transfection of mouse sarcoma cells with cDNAs for chicken cell adhesion molecules.

1988 • 301 citations

Rho: theme and variations

1996 • 290 citations

Purified N-cadherin is a potent substrate for the rapid induction of neurite outgrowth.

1990 • 273 citations

Rho: a connection between membrane receptor signalling and the cytoskeleton

1996 • 271 citations

Phosphorylation of the Drosophila Adherens Junction Protein Armadillo: Roles for Wingless Signal and Zeste-white 3 Kinase

1994 • 251 citations

Ankyrin-binding domain of CD44(GP85) is required for the expression of hyaluronic acid-mediated adhesion function.

1994 • 249 citations

Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion.

1993 • 249 citations

Soluble 80‐kd fragment of cell‐CAM 120/80 disrupts cell‐cell adhesion

1987 • 239 citations

Cytoskeleton—membrane interactions

1996 • 231 citations

Regulation of keratinocyte intercellular junction organization and epidermal morphogenesis by E-cadherin

1992 • 228 citations

Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation

1994 • 223 citations

Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP binding protein, rho.

1993 • 223 citations

Regulated binding of PTP1B-like phosphatase to N-cadherin: control of cadherin-mediated adhesion by dephosphorylation of beta-catenin.

1996 • 221 citations

V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta catenin is not required for the shift.

1995 • 216 citations

Expression and role of E- and P-cadherin adhesion molecules in embryonic histogenesis II. Skin morphogenesis

1989 • 201 citations

CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium.

1995 • 190 citations

Cell Growth and Division

1967 • 187 citations

Deletion of an Amino-Terminal Sequence Stabilizes β-Catenin In Vivo and Promotes Hyperphosphorylation of the Adenomatous Polyposis Coli Tumor Suppressor Protein

1996 • 186 citations

The relationship between intermediate filaments and microfilaments before and during the formation of desmosomes and adherens-type junctions in mouse epidermal keratinocytes.

1987 • 183 citations

Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins.

1996 • 176 citations

Cadherin Function Is Required for Human Keratinocytes to Assemble Desmosomes and Stratify in Response to Calcium

1994 • 172 citations

A dominant inhibitory version of the small GTP-binding protein Rac disrupts cytoskeletal structures and inhibits developmental cell shape changes in Drosophila

1995 • 169 citations

Integrin VLA-3: ultrastructural localization at cell-cell contact sites of human cell cultures.

1989 • 163 citations

Regulation of human B-cell precursor adhesion to bone marrow stromal cells by cytokines that exert opposing effects on the expression of vascular cell adhesion molecule-1 (VCAM-1)

1993 • 155 citations

Rac GTPase interacts with GAPs and target proteins through multiple effector sites.

1995 • 126 citations

Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues.

1989 • 120 citations

Antidesmosomal monoclonal antibody in the diagnosis of intracranial tumours

1987 • 119 citations

Both stimulatory and inhibitory exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins

1992 • 116 citations

Involvement of the GTP binding protein Rho in constitutive endocytosis in Xenopus laevis oocytes.

1995 • 110 citations

Identification and characterization of the human Pgp-1 glycoprotein

1986 • 97 citations

Calcium-induced changes in cytoskeleton and motility of cultured human keratinocytes

1987 • 80 citations

Delayed Assembly of Desmosomes in Keratinocytes with Disrupted Classic-Cadherin-Mediated Cell Adhesion by a Dominant Negative Mutant

1995 • 74 citations

Calcium-Induced Changes in Distribution and Solubility of Cadherins, Integrins and Their Associated Cytoplasmic Proteins in Human Keratinocytes

1995 • 64 citations

An Immunofluorescence Study of the Calcium-Induced Coordinated Reorganization of Microfilaments, Keratin Intermediate Filaments, and Microtubules in Cultured Human Epidermal Keratinocytes

1991 • 48 citations

Arthropod evolution: Same Hox genes, different body plans

1997 • 27 citations

Calcium-Induced Intercellular Adhesion of Keratinocytes Does not Involve Accumulation of β₁Integrins at Cell-Cell Contacts and Does not Involve Changes in the Levels or Phosphorylation of Catenins

1998 • 17 citations