Dbl family proteins

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

ras GENES

1987 • 3,818 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Prediction of Protein Secondary Structure at Better than 70% Accuracy

1993 • 2,958 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1985 • 1,650 citations

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

1984 • 1,644 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Combining evolutionary information and neural networks to predict protein secondary structure

1994 • 1,471 citations

Tyrosine Kinase Activity and Transformation Potency of bcr-abl Oncogene Products

1990 • 1,305 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity

1984 • 913 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

Small GTP-Binding Proteins and the Regulation of the Actin Cytoskeleton

1994 • 822 citations

Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2

1993 • 788 citations

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate

1994 • 749 citations

Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors

1992 • 703 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

Complex formation between RAS and RAF and other protein kinases.

1993 • 633 citations

CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae.

1990 • 605 citations

The ras protein family: evolutionary tree and role of conserved amino acids

1991 • 573 citations

Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain.

1995 • 569 citations

A role for Rac in Tiaml-induced membrane ruffling and invasion

1995 • 562 citations

A role for Rho in Ras transformation.

1995 • 538 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL.

1990 • 535 citations

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

1994 • 518 citations

The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains.

1996 • 452 citations

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product

1991 • 424 citations

Genetic control of bud site selection in yeast by a set of gene products that constitute a morphogenetic pathway

1991 • 411 citations

Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1.

1989 • 406 citations

Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia

1987 • 405 citations

GTPase cascades choreographing cellular behavior: Movement, morphogenesis, and more

1995 • 394 citations

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

1991 • 392 citations

In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome.

1987 • 380 citations

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

1992 • 361 citations

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

1992 • 361 citations

The Ras signal transduction pathway

1994 • 345 citations

The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C.

1994 • 322 citations

PH domain: the first anniversary

1994 • 318 citations

Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates

1992 • 306 citations

Cooperative interaction of S. pombe proteins required for mating and morphogenesis

1994 • 303 citations

Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: A putative RhoRac guanine nucleotide exchange factor

1994 • 297 citations

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.

1992 • 286 citations

Oncogene ect2 is related to regulators of small GTP-binding proteins

1993 • 281 citations

Yeast BUD5, encoding a putative GDP-GTP exchange factor, is necessary for bud site selection and interacts with bud formation gene BEM1

1991 • 280 citations

The BCR gene encodes a novel serine/threonine kinase activity within a single exon

1991 • 273 citations

Crystal structure at 2.2 Å resolution of the pleckstrin homology domain from human dynamin

1994 • 268 citations

Roles of the CDC24 gene product in cellular morphogenesis during the Saccharomyces cerevisiae cell cycle.

1981 • 264 citations

Expression of a Distinctive BCR-ABL Oncogene in Ph ¹ -Positive Acute Lymphocytic Leukemia (ALL)

1988 • 252 citations

Development of cell polarity in budding yeast

1991 • 252 citations

Guanine nucleotide exchange factors: Activators of the Ras superfamily of proteins

1995 • 217 citations

Isolation of a new human oncogene from a diffuse B-cell lymphoma

1985 • 210 citations

Interactions among Proteins Involved in Bud-site Selection and Bud-site Assembly in Saccharomyces cerevisiae

1995 • 209 citations

Pheromone Response in Yeast: Association of Bem1p with Proteins of the MAP Kinase Cascade and Actin

1995 • 209 citations

byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype.

1991 • 208 citations

Tyrosine Phosphorylation of the vav Proto-Oncogene Product in Activated B Cells

1992 • 195 citations

Increased neutrophil respiratory burst in bcr-null mutants

1995 • 193 citations

Pheromone Signalling in Saccharomyces cerevisiae Requires the Small GTP-Binding Protein Cdc42p and Its Activator CDC24

1995 • 192 citations

Expression Cloning of lfc, a Novel Oncogene with Structural Similarities to Guanine Nucleotide Exchange Factors and to the Regulatory Region of Protein Kinase C

1995 • 188 citations

BUD2 encodes a GTPase-activating protein for Budl/Rsrl necessary for proper bud-site selection in yeast

1993 • 185 citations

Membrane ruffling and signal transduction

1994 • 183 citations

The ABL-BCR fusion gene is expressed in chronic myeloid leukemia

1993 • 183 citations

The BCR-ABL oncogene transforms Rat-1 cells and cooperates with v-myc.

1989 • 180 citations

Rho-related proteins: actin cytoskeleton and cell cycle

1995 • 176 citations

Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.

1995 • 162 citations

Direct Involvement of the Small GTP-binding Protein Rho in lbc Oncogene Function

1995 • 156 citations

Alternative forms of the BCR-ABL oncogene have quantitatively different potencies for stimulation of immature lymphoid cells.

1989 • 145 citations

Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome.

1986 • 138 citations

Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras.

1994 • 134 citations

Lfc and Lsc Oncoproteins Represent Two New Guanine Nucleotide Exchange Factors for the Rho GTP-binding Protein

1996 • 125 citations

Guanine nucleotides, protein phosphorylation and the control of translation

1986 • 124 citations

Mechanism of activation of the vav protooncogene.

1991 • 122 citations

Ras-related proteins

1993 • 118 citations

The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro.

1995 • 111 citations

Guanine-nucleotide exchange factors: a family of positive regulators of Ras and related GTPases

1994 • 104 citations

Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae.

1992 • 91 citations

Differences in oncogenic potency but not target cell specificity distinguish the two forms of the BCR/ABL oncogene.

1991 • 89 citations

The Dbl Oncogene Product as a GDP/GTP Exchange Protein for the Rho Family: Its Properties in Comparison with Those of Smg GDS

1994 • 81 citations

Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe.

1994 • 81 citations

Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein.

1994 • 78 citations

Genetic evidence for the roles of the bud-site-selection genes BUD5 and BUD2 in control of the Rsr1p (Bud1p) GTPase in yeast.

1993 • 77 citations

Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides.

1994 • 75 citations

A tumor-specific membrane phosphoprotein marker in human cell hybrids

1981 • 73 citations

Functional Roles for the Pleckstrin and Dbl Homology Regions in the Ras Exchange Factor Son-of-sevenless

1995 • 65 citations

Tyrosine phosphorylation and activation of Vav GTP/GDP exchange activity in antigen receptor-triggered B cells.

1994 • 57 citations

BCR-ABL, ABL-BCR, BCR, and ABL genes are all expressed in individual granulocyte-macrophage colony-forming unit colonies derived from blood of patients with chronic myeloid leukemia

1995 • 50 citations

Hematopoietic development of vav-/- mouse embryonic stem cells.

1994 • 49 citations

Selective transformation of primitive lymphoid cells by the BCR/ABL oncogene expressed in long-term lymphoid or myeloid cultures.

1988 • 48 citations

Regulated and Constitutive Activity by CDC25^Mm (GRF), a Ras-Specific Exchange Factor

1993 • 47 citations

Reduced hormone-stimulated adenylate cyclase activity in NIH-3T3 cells expressing the EJ human bladder ras oncogene.

1986 • 37 citations

Regulated and constitutive activity by CDC25Mm (GRF), a Ras-specific exchange factor.

1993 • 32 citations

Oncogenic Activation of Ras Proteins

1993 • 24 citations

Preferential expression of the dbl protooncogene in some tumors of neuroectodermal origin.

1991 • 11 citations