A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to Rho

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

The MAPK signaling cascade

1995 • 3,300 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

The rat brain postsynaptic density fraction contains a homolog of the drosophila discs-large tumor suppressor protein

1992 • 1,180 citations

p115 RhoGEF, a GTPase Activating Protein for Gα ₁₂ and Gα ₁₃

1998 • 834 citations

Small GTP-Binding Proteins and the Regulation of the Actin Cytoskeleton

1994 • 822 citations

The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades

1998 • 819 citations

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

1994 • 814 citations

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

1997 • 802 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα ₁₃

1998 • 765 citations

Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex.

1996 • 727 citations

Microinjection of recombinant p21rho induces rapid changes in cell morphology.

1990 • 720 citations

Structural determinants for activation of the α-subunit of a heterotrimeric G protein

1994 • 636 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

Mammalian RGS Proteins: Barbarians at the Gate

1998 • 487 citations

PH Domains: Diverse Sequences with a Common Fold Recruit Signaling Molecules to the Cell Surface

1996 • 464 citations

Gα12 and Gα13 Stimulate Rho-dependent Stress Fiber Formation and Focal Adhesion Assembly

1995 • 443 citations

G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.

1994 • 441 citations

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product

1991 • 424 citations

The Small GTPase Rho: Cellular Functions and Signal Transduction

1996 • 404 citations

How receptor tyrosine kinases activate ras

1993 • 393 citations

The Rho GTPase and a Putative RhoGEF Mediate a Signaling Pathway for the Cell Shape Changes in Drosophila Gastrulation

1997 • 384 citations

Rho effectors and reorganization of actin cytoskeleton

1997 • 379 citations

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

1992 • 361 citations

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

1992 • 361 citations

Signaling from the Small GTP-binding Proteins Rac1 and Cdc42 to the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway

1996 • 340 citations

The drosophila gastrulation gene concertina encodes a Gα-like protein

1991 • 319 citations

A putative cell signal encoded by the folded gastrulation gene coordinates cell shape changes during Drosophila gastrulation

1994 • 317 citations

Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product.

1994 • 314 citations

DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila

1998 • 309 citations

Protein–protein interactions: PDZ domain networks

1996 • 292 citations

The pleckstrin homology domain: An intriguing multifunctional protein module

1996 • 285 citations

The G-protein G13 but Not G12 Mediates Signaling from Lysophosphatidic Acid Receptor via Epidermal Growth Factor Receptor to Rho

1998 • 265 citations

The Son of sevenless Gene Product: a Putative Activator of Ras

1992 • 263 citations

G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits.

1991 • 250 citations

GAPs for rho-related GTPases

1994 • 248 citations

Molecular Cloning of the Human Edg2 Protein and Its Identification as a Functional Cellular Receptor for Lysophosphatidic Acid

1997 • 232 citations

Regulated Membrane Localization of Tiam1, Mediated by the NH2-terminal Pleckstrin Homology Domain, Is Required for Rac-dependent Membrane Ruffling and C-Jun NH2-terminal Kinase Activation

1997 • 230 citations

Transforming G Protein-coupled Receptors Potently Activate JNK (SAPK)

1995 • 211 citations

The small GTP-binding protein Rho links G protein-coupled receptors and Gα ₁₂ to the serum response element and to cellular transformation

1997 • 211 citations

A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways.

1994 • 195 citations

Tyrosine Phosphorylation of the vav Proto-Oncogene Product in Activated B Cells

1992 • 195 citations

A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells.

1993 • 176 citations

Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells.

1992 • 161 citations

Identification of a Novel Guanine Nucleotide Exchange Factor for the Rho GTPase

1996 • 161 citations

Signaling by the G Class of G Proteins

1996 • 143 citations

Botulinum ADP-ribosyltransferase C3: a new tool to study low molecular weight GTP-binding proteins

1989 • 137 citations

Lfc and Lsc Oncoproteins Represent Two New Guanine Nucleotide Exchange Factors for the Rho GTP-binding Protein

1996 • 125 citations

Molecular Cloning and Expression Analysis of RatRgs12andRgs14

1997 • 115 citations

Tyrosine Phosphorylation of the vav Proto-oncogene Product Links FcεRI to the Rac1-JNK Pathway

1997 • 113 citations

Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells.

1991 • 110 citations

Interactions between Ras and Raf: Key regulatory proteins in cellular transformation

1995 • 102 citations

Potent Transforming Activity of the G13 α Subunit Defines a Novel Family of Oncogenes

1994 • 99 citations

Minireview: Signal Transduction by G Proteins: 1994 Edition

1995 • 97 citations

G12 Requirement for Thrombin-stimulated Gene Expression and DNA Synthesis in 1321N1 Astrocytoma Cells

1995 • 96 citations

Expression Cloning of lsc, a Novel Oncogene with Structural Similarities to the Dbl Family of Guanine Nucleotide Exchange Factors

1996 • 91 citations

Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin.

1995 • 79 citations

The VAV Family of Signal Transduction Molecules

1996 • 66 citations

Regulation of the actin cytoskeleton, integrins and cell growth by the Rho family of small GTPases.

1996 • 56 citations

Identification of the protein encoded by the human diffuse B-cell lymphoma (dbl) oncogene.

1986 • 40 citations

The G12 coupled thrombin receptor stimulates mitogenesis through the Shc SH2 domain

1997 • 33 citations