Rho-stimulated Contractility Contributes to the Fibroblastic Phenotype of Ras-transformed Epithelial Cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Methods in Enzymology , Vol

1966 • 26,261 citations

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

Isolation and Characterization of a Spontaneously Immortalized Human Breast Epithelial Cell Line, MCF-10

1990 • 1,495 citations

Morphogenetic roles of classic cadherins

1995 • 1,468 citations

Silicone Rubber Substrata: A New Wrinkle in the Study of Cell Locomotion

1980 • 1,333 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion.

1989 • 961 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

1996 • 872 citations

The p160 RhoA-Binding Kinase ROKα Is a Member of a Kinase Family and Is Involved in the Reorganization of the Cytoskeleton

1996 • 866 citations

Expression of Cellular Oncogenes in Human Malignancies

1984 • 840 citations

Small GTP-Binding Proteins and the Regulation of the Actin Cytoskeleton

1994 • 822 citations

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

1997 • 772 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 725 citations

Microinjection of recombinant p21rho induces rapid changes in cell morphology.

1990 • 720 citations

Paxillin: a new vinculin-binding protein present in focal adhesions.

1990 • 687 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly.

1994 • 633 citations

Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway.

1996 • 601 citations

Regulation of Scatter Factor/Hepatocyte Growth Factor Responses by Ras, Rac, and Rho in MDCK Cells

1995 • 547 citations

A role for Rho in Ras transformation.

1995 • 538 citations

p160^ROCK, a Rho‐associated coiled‐coil forming protein kinase, works downstream of Rho and induces focal adhesions

1997 • 510 citations

Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase.

1987 • 503 citations

Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation.

1995 • 451 citations

Ras effectors

1996 • 445 citations

Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia.

1995 • 418 citations

Light-chain phosphorylation controls the conformation of vertebrate non-muscle and smooth muscle myosin molecules

1983 • 393 citations

Cell cycle-dependent activation of Ras

1996 • 389 citations

Protein Kinase N (PKN) and PKN-Related Protein Rhophilin as Targets of Small GTPase Rho

1996 • 384 citations

Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS

1996 • 377 citations

Involvement of microtubules in the control of adhesion-dependent signal transduction

1996 • 358 citations

Oncogenic Ras Activation of Raf/Mitogen-Activated Protein Kinase-Independent Pathways Is Sufficient To Cause Tumorigenic Transformation

1996 • 350 citations

Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members.

1994 • 347 citations

A gene family consisting of ezrin, radixin and moesin Its specific localization at actin filament/plasma membrane association sites

1992 • 334 citations

Association between GTPase activators for Rho and Ras families

1992 • 322 citations

Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia.

1995 • 304 citations

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

1996 • 285 citations

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.

1994 • 270 citations

Critical role of Rho in cell transformation by oncogenic Ras.

1995 • 256 citations

Are stress fibres contractile?

1981 • 224 citations

Aberrant function of the Ras signal transduction pathway in human breast cancer

1995 • 218 citations

Butanedione Monoxime Suppresses Contraction and ATPase Activity of Rabbit Skeletal Muscle1

1989 • 217 citations

Effect of 2,3-butanedione monoxime on myosin and myofibrillar ATPases. An example of an uncompetitive inhibitor

1992 • 206 citations

Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites and cleavage furrows.

1995 • 192 citations

Correlation of myosin light chain phosphorylation with isometric contraction of fibroblasts.

1993 • 186 citations

[74] Microinjection of early SV40 DNA fragments and T antigen

1980 • 176 citations

Transformation of Human Breast Epithelial Cells by c‐Ha‐ras Oncogene

1991 • 162 citations

Rho-stimulated Contractility Contributes to the Fibroblastic Phenotype of Ras-transformed Epithelial Cells

1997 • 161 citations

Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells.

1996 • 142 citations

Botulinum ADP-ribosyltransferase C3: a new tool to study low molecular weight GTP-binding proteins

1989 • 137 citations

KT5926, a potent and selective inhibitor of myosin light chain kinase.

1990 • 130 citations

Chromosome 5 suppresses tumorigenicity of PC3 prostate cancer cells: correlation with re-expression of alpha-catenin and restoration of E-cadherin function.

1995 • 121 citations

Effect of protein kinase inhibitor H‐7 on the contractility, integrity, and membrane anchorage of the microfilament system

1994 • 121 citations

The influence of 2,3-butanedione 2-monoxime (BDM) on the interaction between actin and myosin in solution and in skinned muscle fibres

1994 • 116 citations

ras gene alterations and enhanced levels of ras p21 expression in a spectrum of benign and malignant human mammary tissues.

1986 • 104 citations

Expression of fibronectin variants in vascular and visceral smooth muscle cells in development

1990 • 85 citations

Molecular mechanisms leading to loss of differentiation and gain of invasiveness in epithelial cells

1993 • 79 citations

Cytoskeletal involvement in the modulation of cell-cell junctions by the protein kinase inhibitor H-7

1994 • 79 citations

Effects of 2,3-butanedione monoxime on activation of contraction and crossbridge kinetics in intact and chemically skinned smooth muscle fibres from guinea pig taenia coli

1993 • 41 citations