Rho Guanosine Triphosphatase Mediates the Selective Stabilization of Microtubules Induced by Lysophosphatidic Acid

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

2012 • 10,051 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

Rat monoclonal antitubulin antibodies derived by using a new nonsecreting rat cell line.

1982 • 923 citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

1996 • 872 citations

The p160 RhoA-Binding Kinase ROKα Is a Member of a Kinase Family and Is Involved in the Reorganization of the Cytoskeleton

1996 • 866 citations

Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule binding

1993 • 856 citations

Microtubules containing acetylated alpha-tubulin in mammalian cells in culture.

1987 • 833 citations

Small GTP-Binding Proteins and the Regulation of the Actin Cytoskeleton

1994 • 822 citations

Tau protein function in living cells.

1986 • 727 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 725 citations

A Novel Serine/Threonine Kinase Binding the Ras-related RhoA GTPase Which Translocates the Kinase to Peripheral Membranes

1995 • 711 citations

All classes of intermediate filaments share a common antigenic determinant defined by a monoclonal antibody

1981 • 654 citations

Distinct populations of microtubules: Tyrosinated and nontyrosinated alpha tubulin are distributed differently in vivo

1984 • 532 citations

Lysophosphatidic acid: G-protein signalling and cellular responses

1997 • 492 citations

Tubulin dynamics in cultured mammalian cells.

1984 • 489 citations

Life at the Leading Edge: The Formation of Cell Protrusions

1993 • 442 citations

Microtubules containing detyrosinated tubulin are less dynamic.

1987 • 429 citations

Identification of a Putative Target for Rho as the Serine-Threonine Kinase Protein Kinase N

1996 • 417 citations

Regulation of receptor-mediated endocytosis by Rho and Rac

1996 • 386 citations

Protein Kinase N (PKN) and PKN-Related Protein Rhophilin as Targets of Small GTPase Rho

1996 • 384 citations

Rhotekin, a New Putative Target for Rho Bearing Homology to a Serine/Threonine Kinase, PKN, and Rhophilin in the Rho-binding Domain

1996 • 378 citations

Posttranslational modification and microtubule stability.

1987 • 365 citations

Real-time observations of microtubule dynamic instability in living cells.

1988 • 364 citations

Involvement of microtubules in the control of adhesion-dependent signal transduction

1996 • 358 citations

Individual microtubules in the axon consist of domains that differ in both composition and stability.

1990 • 356 citations

Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA.

1989 • 354 citations

Microtubule dynamics in interphase cells.

1986 • 331 citations

Direct observation of microtubule dynamics in living cells

1988 • 318 citations

Fibroblast contractility and actin organization are stimulated by microtubule inhibitors

1989 • 303 citations

Two monoclonal antibodies to actin: One muscle selective and one generally reactive

1988 • 302 citations

Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum.

1988 • 299 citations

Postpolymerization detyrosination of alpha-tubulin: a mechanism for subcellular differentiation of microtubules.

1987 • 297 citations

Selective stabilization of microtubules oriented toward the direction of cell migration.

1988 • 296 citations

Enhanced stability of microtubules enriched in detyrosinated tubulin is not a direct function of detyrosination level.

1988 • 272 citations

Stabilization and post‐translational modification of microtubules during cellular morphogenesis

1991 • 269 citations

Differential turnover of tyrosinated and detyrosinated microtubules.

1987 • 250 citations

Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells.

1996 • 215 citations

Microtubule Disruption Induces the Formation of Actin Stress Fibers and Focal Adhesions in Cultured Cells: Possible Involvement of the Rho Signal Cascade.

1996 • 214 citations

Focal adhesion assembly

1997 • 212 citations

Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility.

1993 • 200 citations

Observation and quantification of individual microtubule behavior in vivo: microtubule dynamics are cell-type specific.

1993 • 197 citations

Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites and cleavage furrows.

1995 • 192 citations

New features of microtubule behaviour observed in vivo

1988 • 191 citations

A novel partner for the GTP‐bound forms of rho and rac

1995 • 166 citations

Stable, detyrosinated microtubules function to localize vimentin intermediate filaments in fibroblasts.

1995 • 161 citations

Dissociation of LPA-induced cytoskeletal contraction from stress fiber formation by differential localization of RhoA

1997 • 155 citations

Generation of a stable, posttranslationally modified microtubule array is an early event in myogenic differentiation.

1989 • 145 citations

Detyrosination of alpha tubulin does not stabilize microtubules in vivo [published erratum appears in J Cell Biol 1990 Sep;111(3):1325-6]

1990 • 141 citations

Microtubule arrays in differentiated cells contain elevated levels of a post-translationally modified form of tubulin.

1986 • 124 citations

ADP-ribosylation of a small size GTP-binding protein in bovine neutrophils by the C3 exoenzyme of Clostridium botulinum and effect on the cell motility

1991 • 117 citations

Microtubules are stabilized in confluent epithelial cells but not in fibroblasts.

1990 • 103 citations

Microtubule arrays in differentiated cells contain elevated levels of a post-translationally modified form of tubulin.

1986 • 100 citations

Modulation of microtubule dynamic instability in vivo by brain microtubule associated proteins

1995 • 99 citations

Protein phosphatase inhibitors induce the selective breakdown of stable microtubules in fibroblasts and epithelial cells.

1993 • 88 citations

Interaction of the Rho Family Small G Proteins with Kinectin, an Anchoring Protein of Kinesin Motor

1996 • 76 citations

Induction of stable microtubules in 3T3 fibroblasts by TGF-β and serum

1994 • 75 citations

Posttranslational modification of distinct microtubule subpopulations during cell polarization and differentiation in the mouse preimplantation embryo.

1989 • 69 citations

Functional Modification of a 21-Kilodalton G Protein when ADP-Ribosylated by Exoenzyme C3 of Clostridium botulinum

1988 • 66 citations

Centripetal transport of microtubules in motile cells

1995 • 63 citations

Involvement of rho p21 and Its Inhibitory GDP/GTP Exchange Protein (rho GDI) in Cell Motility

1993 • 46 citations

Distribution of detyrosinated microtubules in motile NRK fibroblasts is rapidly altered upon cell‐cell contact: Implications for contact inhibition of locomotion

1992 • 43 citations

Distribution of microtubules containing post‐translationally modified α‐tubulin during drosophila embryogenesis

1990 • 33 citations

In search of membrane receptors for microtubule-based motors — is kinectin a kinesin receptor?

1996 • 33 citations

Depletion of lysophosphatidic acid triggers a loss of oriented detyrosinated microtubules in motile fibroblasts

1996 • 30 citations

Spatial distribution of posttranslationally modified tubulins in polarized cells of developing Artemia

1991 • 29 citations

Morphological alteration of Xenopus oocytes induced by valine‐14 p21^rho depend on isoprenylation and are inhibited by Clostridium botulinum C3 ADP‐ribosyltranferase

1990 • 28 citations

Cells injected with guanosine 5'-[alpha, beta-methylene]triphosphate, an alpha, beta-nonhydrolyzable analog of GTP, show anomalous patterns of tubulin polymerization affecting cell translocation, intracellular movement, and the organization of Golgi elements.

1983 • 27 citations

Isolated plasma membranes induce the loss of oriented detyrosinated microtubules and other contact inhibition-like responses in migrating NRK cells

1994 • 9 citations