Physical State of the Extracellular Matrix Regulates the Structure and Molecular Composition of Cell-Matrix Adhesions

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Cell locomotion and focal adhesions are regulated by substrate flexibility

1997 • 2,930 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Extracellular Matrix Rigidity Causes Strengthening of Integrin–Cytoskeleton Linkages

1997 • 1,218 citations

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.

1995 • 1,202 citations

Synergistic Roles for Receptor Occupancy and Aggregation in Integrin Transmembrane Function

1995 • 900 citations

Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin.

1992 • 811 citations

A 130K protein from chicken gizzard: Its localization at the termini of microfilament bundles in cultured chicken cells

1979 • 794 citations

Cell-to-substrate contacts in living fibroblasts: an interference reflexion study with an evaluation of the technique

1976 • 705 citations

Modulation of Cell Proliferation and Differentiation through Substrate-dependent Changes in Fibronectin Conformation

1999 • 649 citations

Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization.

1989 • 627 citations

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.

1995 • 620 citations

Integrin transmembrane signaling and cytoskeletal control

1995 • 616 citations

Molecular interactions in cell adhesion complexes

1997 • 583 citations

Dynamics and segregation of cell–matrix adhesions in cultured fibroblasts

2000 • 574 citations

Cellular control lies in the balance of forces

1998 • 530 citations

The Zinc-Finger Protein Slug Causes Desmosome Dissociation, an Initial and Necessary Step for Growth Factor–induced Epithelial–Mesenchymal Transition

1997 • 515 citations

The Molecular Architecture of Focal Adhesions

1995 • 479 citations

Molecular diversity of cell-matrix adhesions

1999 • 444 citations

Relationships between fibronectin (LETS protein) and actin

1978 • 428 citations

Immunoelectron microscopic studies of the sites of cell-substratum and cell-cell contacts in cultured fibroblasts.

1982 • 369 citations

Temporal relationships of F-actin bundle formation, collagen and fibronectin matrix assembly, and fibronectin receptor expression to wound contraction.

1990 • 363 citations

Involvement of microtubules in the control of adhesion-dependent signal transduction

1996 • 358 citations

Integrin-cytoskeletal interactions in migrating fibroblasts are dynamic, asymmetric, and regulated.

1993 • 336 citations

Adhesions of fibroblasts to substratum during contact inhibition observed by interference reflection microscopy

1975 • 324 citations

Development of cell surface linkage complexes in cultured fibroblasts.

1985 • 320 citations

Mapping of the alpha-actinin binding site within the beta 1 integrin cytoplasmic domain.

1993 • 267 citations

Assembly of focal adhesions: progress, paradigms, and portents

1996 • 265 citations

Fibronectin and vitronectin regulate the organization of their respective Arg-Gly-Asp adhesion receptors in cultured human endothelial cells.

1988 • 256 citations

Cell surface distribution of fibronectin and vitronectin receptors depends on substrate composition and extracellular matrix accumulation.

1988 • 228 citations

Integrin activation: the link between ligand binding and signal transduction

1996 • 227 citations

Mechanical Stressing of Integrin Receptors Induces Enhanced Tyrosine Phosphorylation of Cytoskeletally Anchored Proteins

1998 • 216 citations

Focal adhesion assembly

1997 • 212 citations

Caldesmon Inhibits Nonmuscle Cell Contractility and Interferes with the Formation of Focal Adhesions

1999 • 197 citations

Focal contacts: Transmembrane links between the extracellular matrix and the cytoskeleton

1989 • 193 citations

The removal of extracellular fibronectin from areas of cell-substrate contact

1981 • 191 citations

Rho-stimulated Contractility Contributes to the Fibroblastic Phenotype of Ras-transformed Epithelial Cells

1997 • 161 citations

Monoclonal antibody characterization of two distant sites required for function of the central cell-binding domain of fibronectin in cell adhesion, cell migration, and matrix assembly.

1991 • 156 citations

Identification of a novel anti‐integrin monoclonal antibody that recognises a ligand‐induced binding site epitope on the β1 subunit

1995 • 151 citations

The distribution of distinct integrins in focal contacts is determined by the substratum composition

1989 • 137 citations

The Inhibitory Anti-β1 Integrin Monoclonal Antibody 13 Recognizes an Epitope That Is Attenuated by Ligand Occupancy

1996 • 130 citations

Actin—membrane interaction in focal adhesions

1990 • 130 citations

Effect of protein kinase inhibitor H‐7 on the contractility, integrity, and membrane anchorage of the microfilament system

1994 • 121 citations

α-Actinin: a direct link between actin and integrins

1991 • 102 citations

Fibronectin and its alpha 5 beta 1-integrin receptor are involved in the wound-repair process of airway epithelium

1996 • 90 citations

Fibronectin is not present in the focal adhesions formed between normal cultured fibroblasts and their substrata.

1980 • 84 citations

Molecular mechanisms for focal adhesion assembly through regulation of protein–protein interactions

1996 • 79 citations

Cell adhesion to laminin 1 or 5 induces isoform-specific clustering of integrins and other focal adhesion components

1998 • 79 citations

Mapping of adherens junction components using microscopic resonance energy transfer imaging

1995 • 58 citations

Fibronectin filaments and actin microfilaments are organized into a fibronexus in Dupuytren's diseased tissue

1991 • 55 citations

Fibronectin Facilitates Corneal Epithelial Wound Healing in Diabetic Rats

1997 • 53 citations

The distribution of fibronectin in attachment sites of chick fibroblasts

1980 • 45 citations

Mutually Exclusive Distribution of the Focal Adhesion Associated Proteins and the Erythrocyte Membrane Skeleton Proteins in the Human Fibroblast Plasma Membrane Undercoat.

1996 • 14 citations