Delivery of Viral Vectors to Tumor Cells: Extracellular Transport, Systemic Distribution, and Strategies for Improvement

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

Cancer genes and the pathways they control

2004 • 4,172 citations

Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5

1997 • 3,081 citations

Progress and problems with the use of viral vectors for gene therapy

2003 • 2,389 citations

Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment

1998 • 2,375 citations

New Methods of Drug Delivery

1990 • 1,730 citations

Gene therapy - promises, problems and prospects

1997 • 1,692 citations

Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.

1995 • 1,682 citations

Openings between Defective Endothelial Cells Explain Tumor Vessel Leakiness

2000 • 1,627 citations

Synthetic DNA delivery systems

2000 • 1,618 citations

Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation

1997 • 1,590 citations

Determinants of tumor blood flow: a review.

1988 • 1,362 citations

Transport of molecules in the tumor interstitium: a review.

1987 • 1,360 citations

Convection-enhanced delivery of macromolecules in the brain.

1994 • 1,357 citations

Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics

2001 • 1,314 citations

Transfer of Genes to Humans: Early Lessons and Obstacles to Success

1995 • 1,023 citations

Modelling the molecular circuitry of cancer

2002 • 948 citations

Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.

1994 • 904 citations

Delivery of molecular and cellular medicine to solid tumors

2012 • 766 citations

An Adenovirus Vector with Genetically Modified Fibers Demonstrates Expanded Tropism via Utilization of a Coxsackievirus and Adenovirus Receptor-Independent Cell Entry Mechanism

1998 • 764 citations

Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy.

1990 • 742 citations

How Viruses Enter Animal Cells

2004 • 726 citations

DNA delivery from polymer matrices for tissue engineering

1999 • 669 citations

Gene Therapy for Cancer: What Have We Done and Where Are We Going?

1997 • 635 citations

Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size.

2000 • 622 citations

Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

2001 • 534 citations

Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice.

1993 • 531 citations

Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies

2003 • 529 citations

Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse.

1992 • 501 citations

Epigenetics and cancer

2004 • 486 citations

Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini

2001 • 481 citations

Enzyme-Catalyzed Activation of Anticancer Prodrugs

2004 • 479 citations

Phase II Trial of Intratumoral Administration of ONYX-015, a Replication-Selective Adenovirus, in Patients With Refractory Head and Neck Cancer

2001 • 467 citations

Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows.

1994 • 463 citations

Targeted gene delivery by tropism-modified adenoviral vectors

1996 • 431 citations

Replicative adenoviruses for cancer therapy

2000 • 424 citations

The next frontier of molecular medicine: Delivery of therapeutics

1998 • 408 citations

PEGylation of Adenovirus with Retention of Infectivity and Protection from Neutralizing Antibody in Vitro and in Vivo

1999 • 399 citations

Breast carcinoma: Pattern of metastasis at autopsy

1983 • 398 citations

Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier.

1992 • 397 citations

Blood clearance rates of adenovirus type 5 in mice

2000 • 397 citations

A phase I trial of CV706, a replication-competent, PSA selective oncolytic adenovirus, for the treatment of locally recurrent prostate cancer following radiation therapy.

2001 • 380 citations

Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissue.

1993 • 368 citations

Insider information: what viruses tell us about endocytosis

2003 • 356 citations

Gene therapy clinical trials worldwide 1989–2004—an overview

2004 • 353 citations

Convection-enhanced distribution of large molecules in gray matter during interstitial drug infusion

1995 • 350 citations

Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: role of gap-junctional intercellular communication.

2000 • 347 citations

Tumor hypoxia: A target for selective cancer therapy

2003 • 341 citations

The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants.

1995 • 339 citations

Variables affecting convection-enhanced delivery to the striatum: a systematic examination of rate of infusion, cannula size, infusate concentration, and tissue—cannula sealing time

1999 • 333 citations

Spatial and temporal control of gene therapy using ionizing radiation

1995 • 316 citations

High-flow microinfusion: tissue penetration and pharmacodynamics

1994 • 311 citations

Expression of Coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers

1999 • 307 citations

Targeted adenovirus gene transfer to endothelial and smooth muscle cells by using bispecific antibodies

1996 • 293 citations

CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors

2001 • 289 citations

Immunity to adenovirus and adeno-associated viral vectors: implications for gene therapy

2003 • 282 citations

Steroid receptor induction of gene transcription: A two-step model

1997 • 269 citations

Evolution of Cell Recognition by Viruses

2001 • 269 citations

Delivery of molecular and cellular medicine to solid tumors

1997 • 268 citations

Targeted adeno-associated virus vector transduction of nonpermissive cells mediated by a bispecific F(ab'γ)2 antibody

1999 • 232 citations

“Stealth” Adenoviruses Blunt Cell-Mediated and Humoral Immune Responses against the Virus and Allow for Significant Gene Expression upon Readministration in the Lung

2001 • 225 citations

Controlled release systems for DNA delivery

2004 • 225 citations

Gene therapy: designer promoters for tumour targeting

2000 • 222 citations

The impact of developmental stage, route of administration and the immune system on adenovirus-mediated gene transfer.

1994 • 217 citations

Points to Consider Response with Clinical Protocol, July 6, 1990

1990 • 213 citations

Preclinical in vivo evaluation of pseudotyped adeno-associated virus vectors for liver gene therapy

2003 • 205 citations

A Targetable, Injectable Adenoviral Vector for Selective Gene Delivery to Pulmonary Endothelium in Vivo

2000 • 202 citations

Integrin αvβ1 Is an Adenovirus Coreceptor

2001 • 198 citations

Extended plasma circulation time and decreased toxicity of polymer-coated adenovirus

2004 • 198 citations

Polymeric implants for cancer chemotherapy

1997 • 193 citations

Monoclonal Antibody Therapy for Cancer

2003 • 192 citations

Targeted gene delivery to Kaposi's sarcoma cells via the fibroblast growth factor receptor.

1997 • 177 citations

Selective activation of anticancer prodrugs by monoclonal antibody–enzyme conjugates

2001 • 174 citations

Adenovirus-mediated interleukin-12 gene therapy for prostate cancer: suppression of orthotopic tumor growth and pre-established lung metastases in an orthotopic model

1999 • 170 citations

Adenovirus Biodistribution and Noninvasive Imaging of Gene Expression In Vivo by Positron Emission Tomography Using Human Sodium/Iodide Symporter as Reporter Gene

2002 • 165 citations

PEGylation of E1-Deleted Adenovirus Vectors Allows Significant Gene Expression on Readministration to Liver

2002 • 163 citations

Liposomal-entrapped doxorubicin: an active agent in AIDS-related Kaposi's sarcoma.

1995 • 163 citations

Concepts of oxygen transport at the microcirculatory level

1998 • 160 citations

Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer and expression in vivo.

1999 • 159 citations

Amphotropic Murine Leukemia Retrovirus Is Not an Acute Pathogen for Primates

1990 • 153 citations

PEGylation of a Vesicular Stomatitis Virus G Pseudotyped Lentivirus Vector Prevents Inactivation in Serum

2003 • 145 citations

Clinical Studies of Liposome-Encapsulated Doxorubicin

1994 • 145 citations

Viral vectors, tools for gene transfer in the nervous system

1998 • 142 citations

Gene therapy for cancer using tumour-specific prodrug activation.

1994 • 136 citations

Biodistribution and Toxicity Studies of VSVG-Pseudotyped Lentiviral Vector after Intravenous Administration in Mice with the Observation of in Vivo Transduction of Bone Marrow

2002 • 134 citations

Antibody-Linked Cytotoxic Agents in the Treatment of Cancer: Current Status and Future Prospects<xref ref-type="fn" rid="FN2">2</xref>

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Transvascular drug delivery in solid tumors

1998 • 132 citations

The molecular basis of the hypoxia response pathway: tumour hypoxia as a therapy target.

1998 • 131 citations

Endocytosis of adenovirus and adenovirus capsid proteins

2003 • 130 citations

Biodistribution of an adenoviral vector carrying the luciferase reporter gene following intravesical or intravenous administration to a mouse

1999 • 129 citations

Biological impediments to monoclonal antibody–based cancer immunotherapy

2004 • 126 citations

Gene therapy strategies for tumor antiangiogenesis

1998 • 126 citations

Intratumoral Spread of Wild-Type Adenovirus Is Limited After Local Injection of Human Xenograft Tumors: Virus Persists and Spreads Systemically at Late Time Points

2003 • 122 citations

Protein, peptide and non-peptide drug PEGylation for therapeutic application

2004 • 122 citations

Adenoviral TNF-α gene therapy and radiation damage tumor vasculature in a human malignant glioma xenograft

1998 • 121 citations

Heat-induced gene expression as a novel targeted cancer gene therapy strategy.

2000 • 120 citations

Increasing Volume of Distribution to the Brain with Interstitial Infusion: Dose, Rather Than Convection, Might Be the Most Important Factor

1996 • 115 citations

Delivery of a stringent dimerizer-regulated gene expression system in a single retroviral vector

2000 • 113 citations

Advancing role of radiolabeled antibodies in the therapy of cancer

2003 • 113 citations

Targeting adenoviral vectors using heterofunctional polyethylene glycol FGF2 conjugates

2003 • 112 citations

Delivery systems intended for in vivo gene therapy of cancer: targeting and replication competent viral vectors

2001 • 111 citations

Generation of Fiber-Mutant Recombinant Adenoviruses for Gene Therapy of Malignant Glioma

1998 • 111 citations

Pre-existing immunity to adenovirus does not prevent tumor regression following intratumoral administration of a vector expressing IL-12 but inhibits virus dissemination

1997 • 108 citations

Adenoviral-mediated transfer of a heat-inducible double suicide gene into prostate carcinoma cells.

1998 • 104 citations

Method for Multiple Portal Vein Infusions in Mice: Quantitation of Adenovirus-Mediated Hepatic Gene Transfer

1996 • 103 citations

Recombinant viruses as a tool for therapeutic vaccination against human cancers

2000 • 99 citations

A Gene Delivery System Activatable by Disease-Associated Matrix Metalloproteinases

1997 • 99 citations

Immune Response to Poxvirus Infections in Various Animals

2002 • 98 citations

Available volume fraction of macromolecules in the extravascular space of a fibrosarcoma: implications for drug delivery.

1999 • 97 citations

Intravenous administration of recombinant adenoviruses causes thrombocytopenia, anemia and erythroblastosis in rabbits

1999 • 96 citations

Dangerous liaisons: the role of “danger” signals in the immune response to gene therapy

2002 • 95 citations

Pharmaceutical Perspectives of Nucleic Acid-Based Therapy

2002 • 95 citations

UPTAKE OF LIPOSOMES BY RAT AND MOUSE HEPATOCYTES AND KUPFFER CELLS

1983 • 94 citations

A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology

2002 • 93 citations

Use of Transcriptional Regulatory Sequences of Telomerase (hTER and hTERT) for Selective Killing of Cancer Cells

2000 • 90 citations

Imaging and tissue biodistribution of 99mTc-labeled adenovirus knob (serotype 5)

1998 • 89 citations

The efficiency of cell targeting by recombinant retroviruses depends on the nature of the receptor and the composition of the artificial cell-virus linker

1992 • 87 citations

Gene therapy for cancer

1999 • 87 citations

Therapeutic efficacy of the suicide gene driven by the promoter of vascular endothelial growth factor gene against hypoxic tumor cells.

2000 • 87 citations

In vivo cancer gene therapy with a recombinant interleukin-2 adenovirus vector.

1996 • 81 citations

Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini

2001 • 79 citations

Evaluation of the Biodistribution, Persistence, Toxicity, and Potential of Germ-Line Transmission of a Replication-Competent Human Adenovirus Following Intraprostatic Administration in the Mouse

2000 • 79 citations

Interstitial hydraulic conductivity in a fibrosarcoma

2000 • 78 citations

Use of a novel cross-linking method to modify adenovirus tropism

1997 • 78 citations

Systemic dissemination of viral vectors during intratumoral injection.

2003 • 76 citations

Conditional gene targeting for cancer gene therapy

2001 • 75 citations

Amplification and Spread of Viruses in a Growing Plaque

1999 • 73 citations

Cytokine- and chemokine-based gene therapy for cancer.

2003 • 73 citations

Strategy for achieving selective killing of carcinomas.

1994 • 71 citations

Activation of the Radiosensitive EGR-1 Promoter Induces Expression of the Herpes Simplex Virus Thymidine Kinase Gene and Sensitivity of Human Glioma Cells to Ganciclovir

1995 • 69 citations

How to overcome (and exploit) tumor hypoxia for targeted gene therapy

2003 • 69 citations

Selective transduction of protease-rich tumors by matrix-metalloproteinase-targeted retroviral vectors

1999 • 67 citations

Poly(Ethylene Glycol) with Reactive Endgroups: I. Modification of Proteins

1995 • 67 citations

Mapping theIn VivoDistribution of Herpes Simplex Virions

1998 • 66 citations

The Liver Is a Major Organ for Clearing Simian Immunodeficiency Virus in Rhesus Monkeys

2002 • 66 citations

Use of Quantitative TaqMan Real-Time PCR to Track the Time-Dependent Distribution of Gene Transfer Vectors in Vivo

2000 • 65 citations

Adaptive and innate immune responses to gene transfer vectors: role of cytokines and chemokines in vector function

2003 • 63 citations

Endothelial Cell-Specific Expression of Tumor Necrosis Factor-αfrom the KDR or E-Selectin Promoters Following Retroviral Delivery

1997 • 62 citations

Fibroblast Growth Factor 2-Retargeted Adenoviral Vectors Exhibit a Modified Biolocalization Pattern and Display Reduced Toxicity Relative to Native Adenoviral Vectors

2000 • 61 citations

Distribution of drugs following controlled delivery to the brain interstitium

1995 • 59 citations

Review: Poly(Ethylene Glycol)s with Reactive Endgroups. II. Practical Consideration for the Preparation of Protein-PEG Conjugates

1996 • 59 citations

Targeting Retroviral Vectors to CD34-Expressing Cells: Binding to CD34 Does Not Catalyze Virus-Cell Fusion

1999 • 58 citations

Retrovirus Targeting by Tropism Restriction to Melanoma Cells

1999 • 57 citations

Use of L-plastin promoter to develop an adenoviral system that confers transgene expression in ovarian cancer cells but not in normal mesothelial cells

1999 • 56 citations

Biomedical Engineering

2005 • 56 citations

The Resistance of Retroviral Vectors Produced from Human Cells to Serum Inactivation In Vivo and In Vitro Is Primate Species Dependent

1999 • 54 citations

A Novel Method for Viral Gene Delivery in Solid Tumors

2005 • 54 citations

Cellular and Intercellular Transport Pathways in Exchange Vessels

1992 • 51 citations

Available Space and Extracellular Transport of Macromolecules: Effects of Pore Size and Connectedness

2001 • 49 citations

Quantification of Sinusoidal Cell Function in Vivo

1993 • 46 citations

Delivery of adenoviral vectors to the prostate for gene therapy

1999 • 45 citations

Butyrate-inducible and tumor-restricted gene expression by adenovirus vectors.

1994 • 44 citations

Immune responses to replication-defective HSV-1 type vectors within the CNS: implications for gene therapy

2003 • 44 citations

Cancer Gene Therapy: Past Achievements And Future Challenges

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Eradication of Myc-overexpressing small cell lung cancer cells transfected with herpes simplex virus thymidine kinase gene containing Myc-Max response elements.

1996 • 42 citations

Quantitative analysis of intratumoral infusion of color molecules

2001 • 42 citations

Extended release of adenovirus from polymer microspheres: potential use in gene therapy for brain tumors

1997 • 40 citations

Interaction of viruses with sinusoidal cells.

1982 • 40 citations

Phase I trial of dose-intense liposome-encapsulated doxorubicin in patients with advanced sarcoma.

1997 • 36 citations

Characterisation of systemic dissemination of nonreplicating adenoviral vectors from tumours in local gene delivery

2005 • 34 citations

Envelope-Targeted Retrovirus Vectors Transduce Melanoma Xenografts but Not Spleen or Liver

2002 • 33 citations

Liver Sinusoidal Endothelial Cells Are Not Permissive for Adenovirus Type 5

2000 • 31 citations

Atomic force microscopy imaging of retroviruses: Human immunodeficiency virus and murine leukemia virus

2004 • 29 citations

Targeting a Recombinant Adenovirus Vector to HCC Cells Using a Bifunctional Fab-Antibody Conjugate

2000 • 27 citations

Selective Targeting and Inducible Destruction of Human Cancer Cells by Retroviruses with Envelope Proteins Bearing Short Peptide Ligands

2002 • 25 citations

Factors Affecting Long-Term Expression of a Secreted Transgene Product after Intravenous Administration of a Retroviral Vector

2001 • 25 citations

Virology and immunology of gene therapy, or virology and immunology of high MOI infection with defective viruses

2003 • 24 citations

Signaling antibodies complexed with adenovirus circumvent CAR and integrin interactions and improve gene delivery

2000 • 24 citations

Catalytic Antibodies as Magic Bullets

2000 • 23 citations

Propagation of viruses on micropatterned host cells

2003 • 23 citations

Retroviral hybrid LTR vector strategy: functional analysis of LTR elements and generation of endothelial cell specificity

2004 • 20 citations

Generation of Fiber-Mutant Recombinant Adenoviruses for Gene Therapy of Malignant Glioma

1998 • 15 citations

Gene therapy for carcinoma of the breast: Genetic ablation strategies

1999 • 11 citations

Use of hypoxia-regulated gene expression in tumor-specific gene therapy.

2001 • 8 citations

Preface

1997 • 6 citations

Interstitial transport of macromolecules: implication for nucleic acid delivery in solid tumors

2002 • 6 citations

Interstitial transport of macromolecules

2010 • 3 citations