Targeting Retroviral Vectors to CD34-Expressing Cells: Binding to CD34 Does Not Catalyze Virus-Cell Fusion

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Membrane Fusion

1990 • 2,458 citations

Transcriptional Activation by Tetracyclines in Mammalian Cells

1995 • 2,458 citations

Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell

1996 • 2,160 citations

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

1983 • 1,857 citations

Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells.

1984 • 1,193 citations

CD34: structure, biology, and clinical utility [see comments]

1996 • 891 citations

Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells

1991 • 869 citations

CD34: structure, biology, and clinical utility [see comments]

1996 • 690 citations

A transient three-plasmid expression system for the production of high titer retroviral vectors

1995 • 686 citations

Regulation of Simian Virus 40 Transcription: Sensitive Analysis of the RNA Species Present Early in Infections by Virus or Viral DNA

1979 • 623 citations

Membrane Fusion

1992 • 613 citations

Tissue-Specific Targeting of Retroviral Vectors Through Ligand-Receptor Interactions

1994 • 424 citations

Function of the cytoplasmic domain of a retroviral transmembrane protein: p15E-p2E cleavage activates the membrane fusion capability of the murine leukemia virus Env protein

1994 • 247 citations

Receptor choice determinants in the envelope glycoproteins of amphotropic, xenotropic, and polytropic murine leukemia viruses

1992 • 242 citations

Retroviral retargeting by envelopes expressing an N-terminal binding domain

1995 • 225 citations

Retroviral vectors displaying functional antibody fragments

1993 • 207 citations

Structure of a Murine Leukemia Virus Receptor-Binding Glycoprotein at 2.0 Angstrom Resolution

1997 • 202 citations

Generation of targeted retroviral vectors by using single-chain variable fragment: an approach to in vivo gene delivery.

1995 • 201 citations

A versatile and potentially general approach to the targeting of specific cell types by retroviruses: application to the infection of human cells by means of major histocompatibility complex class I and class II antigens by mouse ecotropic murine leukemia virus-derived viruses.

1989 • 131 citations

An amino-terminal fragment of the Friend murine leukemia virus envelope glycoprotein binds the ecotropic receptor

1991 • 129 citations

Targeting retrovirus entry.

1996 • 117 citations

Targeted infection of human cells via major histocompatibility complex class I molecules by Moloney murine leukemia virus-derived viruses displaying single-chain antibody fragment-envelope fusion proteins

1996 • 114 citations

Basis for receptor specificity of nonecotropic murine leukemia virus surface glycoprotein gp70SU

1992 • 112 citations

Determination of the binding affinity of an anti-CD34 single-chain antibody using a novel, flow cytometry based assay

1997 • 95 citations

Identification of a subdomain in the Moloney murine leukemia virus envelope protein involved in receptor binding

1996 • 95 citations

Functional analysis of the cytoplasmic tail of Moloney murine leukemia virus envelope protein

1997 • 93 citations

Progress with retroviral gene vectors

2000 • 90 citations

Modifying the host range properties of retroviral vectors

1999 • 87 citations

The efficiency of cell targeting by recombinant retroviruses depends on the nature of the receptor and the composition of the artificial cell-virus linker

1992 • 87 citations

Chemical modification of an ecotropic murine leukemia virus results in redirection of its target cell specificity

1991 • 86 citations

Analysis of the functional and host range-determining regions of the murine ectropic and amphotropic retrovirus envelope proteins

1993 • 83 citations

Uncoupled expression of Moloney murine leukemia virus envelope polypeptides SU and TM: a functional analysis of the role of TM domains in viral entry

1994 • 76 citations

Detection of receptor-specific murine leukemia virus binding to cells by immunofluorescence analysis

1992 • 75 citations

Identification of the block in targeted retroviral-mediated gene transfer

1999 • 73 citations

Detection of an L-selectin ligand on a hematopoietic progenitor cell line

1994 • 61 citations

Retroviral Display of Antibody Fragments; Interdomain Spacing Strongly Influences Vector Infectivity

1996 • 60 citations

Expression of chimeric envelope proteins in helper cell lines and integration into Moloney murine leukemia virus particles.

1996 • 55 citations

Targeting Retroviral Vectors to Vascular Lesions by Genetic Engineering of the MoMLV gp70 Envelope Protein

1997 • 52 citations

Identification of Regions in the Moloney Murine Leukemia Virus SU Protein That Tolerate the Insertion of an Integrin-Binding Peptide

2000 • 51 citations

Identification of envelope protein residues required for the expanded host range of 10A1 murine leukemia virus

1997 • 50 citations

Functional Domains in the Retroviral Transmembrane Protein

1998 • 46 citations

Retroviral targeted delivery.

1996 • 45 citations

Antibody-mediated binding of a murine ecotropic moloney retroviral vector to human cells allows internalization but not the establishment of the proviral state

1988 • 43 citations

Functional interactions between monomers of the retroviral envelope protein complex

1997 • 42 citations

Mutational Analysis of the Fusion Peptide of Moloney Murine Leukemia Virus Transmembrane Protein p15E

1998 • 40 citations

Evaluation of retroviral vectors based on the gibbon ape leukemia virus.

1995 • 19 citations

Anti-CD34+ fabs generated against hematopoietic stem cells in HIV-derived combinatorial immunoglobulin library suggest antigen-selected autoantibodies

1998 • 10 citations

Development of Retroviral Vectors that Target Hematopoietic Stem Cells

2000 • 1 citations