Concepts of oxygen transport at the microcirculatory level

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1989 • 3,308 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

1955 • 2,174 citations

Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation

1997 • 1,590 citations

Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.

1996 • 1,183 citations

Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck

1997 • 1,057 citations

Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck

1996 • 930 citations

Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

1988 • 811 citations

Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix

1993 • 811 citations

Pathophysiology of ischaemia reperfusion injury: Central role of the neutrophil

1991 • 520 citations

23 Genetic instability induced by the tumor microenvironment

1997 • 429 citations

Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers

1996 • 424 citations

Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells.

1988 • 380 citations

Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma.

1996 • 365 citations

Microvascular and tissue oxygen distribution

1996 • 277 citations

Analysis of the Effects of Oxygen Supply and Demand on Hypoxic Fraction in Tumors

1995 • 268 citations

Acute hypoxia in tumors: Implications for modifiers of radiation effects

1986 • 267 citations

Blood flow, metabolism, cellular microenvironment, and growth rate of human tumor xenografts.

1989 • 266 citations

Intussusceptive Microvascular Growth in a Human Colon Adenocarcinoma Xenograft: A Novel Mechanism of Tumor Angiogenesis

1996 • 258 citations

Cell distribution in capillary networks

1980 • 219 citations

A reduction in the in situ rates of oxygen and glucose consumption of cells in EMT6/Ro spheroids during growth

1985 • 186 citations

Mammary fibroblasts may influence breast tumor angiogenesis via hypoxia-induced vascular endothelial growth factor up-regulation and protein expression.

1994 • 185 citations

Drug Resistance in Oncology

1994 • 173 citations

Microvascular studies on the origins of perfusion-limited hypoxia.

1996 • 162 citations

Drug Resistance in Oncology

1997 • 160 citations

Morphologic and hemodynamic comparison of tumor and healing normal tissue microvasculature

1989 • 152 citations

Measuring Tumor Hypoxia.

1996 • 131 citations

The importance of the pre-irradiation breathing times of oxygen and carbogen (5% CO2: 95% O2) on the in vivo radiation response of a murine sarcoma

1977 • 128 citations

Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck

1996 • 123 citations

Temporal heterogeneity in microregional erythrocyte flux in experimental solid tumours

1995 • 108 citations

Hypoxia-induced drug resistance: comparison to P-glycoprotein-associated drug resistance

1991 • 108 citations

Measuring tumor hypoxia

1996 • 104 citations

Fluctuations in microvascular blood flow parameters caused by hemodynamic mechanisms

1994 • 103 citations

Perivascular oxygen tensions in a transplantable mammary tumor growing in a dorsal flap window chamber.

1992 • 103 citations

Tumor hypoxia and heterogeneity: Challenges and opportunities for the future

1996 • 103 citations

Determination of local oxygen consumption rates in tumors.

1994 • 100 citations

Theoretical Simulation of Oxygen Transport to Tumors by Three-Dimensional Networks of Microvessels

1998 • 95 citations

A comparison of tumor and normal tissue microvascular hematocrits and red cell fluxes in a rat window chamber model

1993 • 89 citations

Perivascular Oxygen Tensions in a Transplantable Mammary Tumor Growing in a Dorsal Flap Window Chamber

1992 • 86 citations

Measurement of oxygen diffusion distance in tumor cubes using a fluorescent hypoxia probe

1992 • 81 citations

Microregional blood flow in murine and human tumours assessed using laser Doppler microprobes.

1996 • 64 citations

Arteriolar oxygenation in tumour and subcutaneous arterioles: effects of inspired air oxygen content.

1996 • 58 citations

The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment

1993 • 54 citations

The effect of hypoxia on acquired drug resistance and response to epidermal growth factor in chinese hamster lung fibroblasts and human breast‐cancer cells in vitro

1993 • 43 citations

Anomalous patterns of nitroimidazole binding adjacent to necrosis in human glioma xenografts: possible role of decreased oxygen consumption

1997 • 38 citations

Effect of vascular marker Hoechst 33342 on tumour perfusion and cardiovascular function in the mouse

1990 • 38 citations

Cinnarizine and flunarizine as radiation sensitisers in two murine tumours

1988 • 34 citations

Micro-regional mapping of HbO2 saturations and blood flow following nicotinamide administration

1994 • 19 citations

Effects of the Calcium Channel Blocker Flunarizine on the Hemodynamics and Oxygenation of Tumor Microvasculature

1992 • 19 citations

A feasibility study of a new approach to clinical radiosensitisation: hypothermia and hyperbaric oxygen in combination with pharmacological vasodilatation

1986 • 14 citations

Factors Influencing the Thermosensitivity of Two Rodent Tumors

1992 • 9 citations

In vivo oxygen consumption rate of DS sarcoma cells on inhibition of DNA synthesis.

1996 • 8 citations

The effect of flunarizine on the viscosity of human and rat erythrocyte suspensions in conditions of extreme hypoxia and lactic acidosis

1992 • 4 citations