Immune responses to replication-defective HSV-1 type vectors within the CNS: implications for gene therapy

Herpes Simplex Virus-1 Entry into Cells Mediated by a Novel Member of the TNF/NGF Receptor Family

1996 • 1,068 citations

Entry of Alphaherpesviruses Mediated by Poliovirus Receptor-Related Protein 1 and Poliovirus Receptor

1998 • 905 citations

Infections with Herpes Simplex Viruses

1986 • 774 citations

A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes

1994 • 553 citations

The herpes simplex virus amplicon: A new eucaryotic defective-virus cloning-amplifying vector

1982 • 507 citations

A Cell Surface Protein with Herpesvirus Entry Activity (HveB) Confers Susceptibility to Infection by Mutants of Herpes Simplex Virus Type 1, Herpes Simplex Virus Type 2, and Pseudorabies Virus

1998 • 497 citations

A Defective HSV-1 Vector Expresses Escherichia coli β-Galactosidase in Cultured Peripheral Neurons

1988 • 417 citations

A Newly Identified Member of the Tumor Necrosis Factor Receptor Superfamily with a Wide Tissue Distribution and Involvement in Lymphocyte Activation

1997 • 302 citations

Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1

1992 • 296 citations

Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells

1996 • 277 citations

Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP.

1996 • 271 citations

A latent, nonpathogenic HSV-1-derived vector stably expresses β-galactosidase in mouse neurons

1990 • 264 citations

Deletion of multiple immediate–early genes from herpes simplex virus reduces cytotoxicity and permits long-term gene expression in neurons

1998 • 242 citations

Herpesvirus vector gene transfer and expression of β–glucuronidase in the central nervous system of MRS VII mice

1992 • 207 citations

In Vivo Expression of β-Galactosidase in Hippocampal Neurons by HSV-Mediated Gene Transfer

1992 • 204 citations

Expression of nerve growth factor in vivo from a defective herpes simplex virus 1 vector prevents effects of axotomy on sympathetic ganglia.

1992 • 203 citations

Herpes Simplex Virus Type 1 DNA Amplified as Bacterial Artificial Chromosome inEscherichia coli:Rescue of Replication-Competent Virus Progeny and Packaging of Amplicon Vectors

1998 • 198 citations

Improved Helper Virus-Free Packaging System for HSV Amplicon Vectors Using an ICP27-Deleted, Oversized HSV-1 DNA in a Bacterial Artificial Chromosome

2001 • 193 citations

An Enhanced Packaging System for Helper-Dependent Herpes Simplex Virus Vectors

1998 • 183 citations

An infectious transfer and expression system for genomic DNA loci in human and mouse cells

2001 • 170 citations

Replication-defective herpes simplex virus vectors for gene transfer in vivo.

1996 • 168 citations

A novel function of the herpes simplex virus type 1 Fc receptor: participation in bipolar bridging of antiviral immunoglobulin G

1989 • 166 citations

Periodic transcription of yeast histone genes

1982 • 160 citations

Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection

1988 • 135 citations

In Vivo Immune Evasion Mediated by the Herpes Simplex Virus Type 1 Immunoglobulin G Fc Receptor

1998 • 130 citations

Expression of human HPRT mRNA in brains of mice infected with a recombinant herpes simplex virus-1 vector

1989 • 127 citations

HLA class I molecules are not transported to the cell surface in cells infected with herpes simplex virus types 1 and 2.

1994 • 126 citations

Herpesviruses--Immune Escape Artists?

1992 • 116 citations

Herpes Simplex Virus Type 1 Glycoprotein gC Mediates Immune Evasion In Vivo

1998 • 111 citations

Human CD8+ herpes simplex virus-specific cytotoxic T-lymphocyte clones recognize diverse virion protein antigens

1992 • 105 citations

Gene Transfer into Mammalian Central Nervous System Using Herpes Virus Vectors: Extended Expression of Bacterial lacZ in Neurons Using the Neuron-Specific Enolase Promoter

1992 • 104 citations

Inflammatory effects of gene transfer into the CNS with defective HSV-1 vectors.

1994 • 101 citations

Expression of herpes simplex virus 1 glycoprotein B by a recombinant vaccinia virus and protection of mice against lethal herpes simplex virus 1 infection.

1987 • 94 citations

HSV-1 Amplicon Vectors—Simplicity and Versatility

2000 • 82 citations

Herpes Simplex Virus Latency-Associated Transcript Encodes a Protein Which Greatly Enhances Virus Growth, Can Compensate for Deficiencies in Immediate-Early Gene Expression, and Is Likely To Function during Reactivation from Virus Latency

1999 • 67 citations

Masters of deception: A review of herpesvirus immune evasion strategies

1996 • 65 citations

Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS

2003 • 64 citations

Role of keratinocytes in human recurrent herpetic lesions. Ability to present herpes simplex virus antigen and act as targets for T lymphocyte cytotoxicity in vitro.

1989 • 64 citations

Gene transfer to brain using herpes simplex virus vectors

1994 • 63 citations

Development of herpes simplex virus-1 amplicon–based immunotherapy for chronic lymphocytic leukemia

2001 • 62 citations

Expression of vhs and VP16 during HSV-1 helper virus-free amplicon packaging enhances titers

2001 • 58 citations

Expression of Human Immunodeficiency Virus Type 1 gp120 from Herpes Simplex Virus Type 1-Derived Amplicons Results in Potent, Specific, and Durable Cellular and Humoral Immune Responses

2002 • 55 citations

Transfer of the nerve growth factor gene into cell lines and cultured neurons using a defective Herpes Simplex virus vector. Transfer of the NGF gene into cells by a HSV-1 vector

1994 • 53 citations

Dendritic Cells Transduced with HSV-1 Amplicons Expressing Prostate-Specific Antigen Generate Antitumor Immunity in Mice

2001 • 52 citations

Discordance between Expression and Genome Transfer Titering of HSV Amplicon Vectors: Recommendation for Standardized Enumeration

2000 • 50 citations

Design and application of HSV vectors for neuroprotection

2000 • 45 citations

Human natural killer cell recognition of herpes simplex virus type 1 glycoproteins: specificity analysis with the use of monoclonal antibodies and antigenic variants.

1984 • 42 citations

In vitro neutralization of HSV‐2: Inhibition by binding of normal IgG and purified Fc to virion Fc receptor (FcR)

1984 • 36 citations

Immunological hiding of herpesvirus-infected cells

2000 • 35 citations

Replication-defective herpes simplex virus vectors for neurotrophic factor gene transfer in vitro and in vivo

1999 • 33 citations

Gene Transfer and Therapy in the Nervous System

1992 • 23 citations

Vaccines Against Genital Herpes

2002 • 22 citations

Characterization of RNA transcripts from herpes simplex virus-1 DNA fragment BamHI-B

1989 • 22 citations

HSV Amplicon-Mediated Delivery of LIGHT Enhances the Antigen-Presenting Capacity of Chronic Lymphocytic Leukemia

2002 • 21 citations

Gene Transfer into the Nervous System using Recombinant Herpes Virus Vectors

1992 • 11 citations

Transfer of Human HPRT Gene Sequence into Neuronal Cells by a Herpes Simplex Virus Derived Vector

1989 • 5 citations