Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

1995 • 6,103 citations

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

1989 • 3,477 citations

Synthetic DNA delivery systems

2000 • 1,618 citations

Polyamidoamine cascade polymers mediate efficient transfection of cells in culture

1993 • 1,186 citations

Poly(ethylenimine) and its role in gene delivery

1999 • 1,182 citations

The Proton Sponge: a Trick to Enter Cells the Viruses Did Not Exploit

1997 • 868 citations

Amino Acid Analysis: Aqueous Dimethyl Sulfoxide As Solvent for the Ninhydrin Reaction

1968 • 826 citations

The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems.

1994 • 668 citations

Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle.

1992 • 657 citations

Transferrin-polycation conjugates as carriers for DNA uptake into cells.

1990 • 657 citations

Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery

2000 • 515 citations

Efficient Gene Transfer by Histidylated Polylysine/pDNA Complexes

1999 • 494 citations

Key issues in non-viral gene delivery

1998 • 441 citations

A Method for the High Efficiency of Water-Soluble Carbodiimide-Mediated Amidation

1994 • 326 citations

Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand

1992 • 325 citations

Design of imidazole-containing endosomolytic biopolymers for gene delivery

2000 • 264 citations

Branched Cationic Peptides for Gene Delivery: Role of Type and Number of Cationic Residues in Formation and in Vitro Activity of DNA Polyplexes

1999 • 227 citations

Peptide-Mediated Gene Delivery: Influence of Peptide Structure on Gene Expression

1997 • 218 citations

Structure of Nucleic Acid-Poly Base Complexes

1970 • 177 citations

Atomic force microscopic analysis of the influence of the molecular weight of poly(L)lysine on the size of polyelectrolyte complexes formed with DNA.

1996 • 153 citations

Polyhistidine mediates an acid-dependent fusion of negatively charged liposomes

1984 • 135 citations

Key issues in non-viral gene delivery: Adv Drug Deliv Rev

1998 • 131 citations

Poly(4-hydroxy-<scp>l</scp>-proline ester): Low-Temperature Polycondensation and Plasmid DNA Complexation

1999 • 121 citations

Polycation-induced fusion of negatively-charged vesicles

1982 • 115 citations

Delivery of DNA into mammalian cells by receptor-mediated endocytosis and gene therapy

1995 • 98 citations

Molecular aspects of the bilayer stabilization induced by poly(l-lysines) of varying size in cardiolipin liposomes

1985 • 86 citations

Biodegradable and pH‐sensitive hydrogels: Synthesis by crosslinking of N,N‐dimethylacrylamide copolymer precursors

1994 • 80 citations

DNA interpolyelectrolyte complexes as a tool for efficient cell transformation

1991 • 80 citations

Formation of Stable and Monodispersive Polyion Complex Micelles in Aqueous Medium from Poly(L-lysine) And Poly(Ethylene Glycol)-Poly(Aspartic Acid) Block Copolymer

1997 • 75 citations

Gene delivery systems: Bridging the gap between recombinant viruses and artificial vectors

1998 • 71 citations

Cytotoxicity for tumor cells of cationic proteins from human neutrophil granules.

1976 • 71 citations

Molecular “recognition” in interpolymer interactions and matrix polymerization

1989 • 59 citations

Polylysine-containing peptides, including the carboxyl-terminal segment of the human c-Ki-ras 2 protein, affect the activity of some key membrane enzymes.

1987 • 57 citations

Spin-label electron spin resonance studies on the interactions of lysine peptides with phospholipid membranes

1997 • 52 citations

Cytolytic effect of polylysine on rabbit polymorphonuclear leukocytes

1985 • 32 citations

Receptor-Targeted Transfection Using Stable Maleimido-Transferrin/Thio-Poly-L-Lysine Conjugates

1993 • 30 citations

Conformational studies of amphipathic α-helical peptides containing an amino acid with a long alkyl chain and their anchoring to lipid bilayer liposomes

1991 • 22 citations

Changes of plasma membrane permeability in neutrophils treated with polycations

1991 • 19 citations

Polylysine activates membrane-bound adenylyl cyclase from Xenopus laevis oocytes through the Gs transducing protein

1991 • 7 citations