Tumor hypoxia: A target for selective cancer therapy

Hypoxia — a key regulatory factor in tumour growth

2002 • 4,942 citations

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

2001 • 4,537 citations

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1989 • 3,308 citations

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

2001 • 3,215 citations

Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects

2001 • 2,558 citations

In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse

1999 • 2,410 citations

Regulation of angiogenesis by hypoxia: role of the HIF system

2003 • 2,404 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Regulation of Mammalian O₂Homeostasis by Hypoxia-Inducible Factor 1

1999 • 1,882 citations

Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix.

1996 • 1,747 citations

Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

2002 • 1,512 citations

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

2001 • 1,326 citations

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

2003 • 1,276 citations

HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression

2001 • 1,230 citations

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.

2000 • 1,087 citations

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α

2000 • 893 citations

Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effect in Carcinogenesis

2002 • 785 citations

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF

2003 • 713 citations

Hypoxia Induces Cyclooxygenase-2 via the NF-κB p65 Transcription Factor in Human Vascular Endothelial Cells

1997 • 673 citations

Hypoxia and drug resistance

1994 • 555 citations

Mechanisms of p53-dependent apoptosis

2001 • 542 citations

Combination bacteriolytic therapy for the treatment of experimental tumors

2001 • 532 citations

Mechanisms of p53-dependent apoptosis

2001 • 474 citations

TAT-Mediated Protein Transduction into Mammalian Cells

2001 • 381 citations

The E-cadherin–catenin complex in tumour metastasis

2000 • 347 citations

Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategies

2000 • 345 citations

Tumor angiogenesis and accessibility: Role of vascular endothelial growth factor

2002 • 262 citations

Hypoxia-associated Induction of Early Growth Response-1 Gene Expression

1999 • 250 citations

Tumor angiogenesis and accessibility: Role of vascular endothelial growth factor

2002 • 239 citations

The macrophage – a novel system to deliver gene therapy to pathological hypoxia

2000 • 208 citations

Protection against ischemic brain injury by protein therapeutics

2002 • 196 citations

Regulation of macrophage production of vascular endothelial growth factor (VEGF) by hypoxia and transforming growth factor β-1

1998 • 193 citations

Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis

2002 • 190 citations

Hypoxia as a target for combined modality treatments

2002 • 180 citations

Bcl-2 Family Members and Functional Electron Transport Chain Regulate Oxygen Deprivation-Induced Cell Death

2002 • 175 citations

Oxygen deprivation induced cell death: an update.

2002 • 165 citations

Dominant-Negative Hypoxia-Inducible Factor-1α Reduces Tumorigenicity of Pancreatic Cancer Cells through the Suppression of Glucose Metabolism

2003 • 165 citations

AQ4N: a new approach to hypoxia-activated cancer chemotherapy

2000 • 162 citations

Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1.

1999 • 162 citations

Bifidobacterium longum as a delivery system for gene therapy of chemically induced rat mammary tumors

2001 • 152 citations

Antitumor effect of TAT-oxygen-dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells.

2002 • 144 citations

A novel hypoxia-inducible factor (HIF) activated oncolytic adenovirus for cancer therapy

2003 • 129 citations

Tirapazamine: a hypoxia-activated topoisomerase II poison.

2002 • 121 citations

New Oncolytic Adenoviruses with Hypoxia- and Estrogen Receptor-Regulated Replication

2002 • 115 citations

The influence of microenvironmental factors during cancer therapy.

1994 • 113 citations

Hypoxia-mediated tumour targeting

2003 • 94 citations

Apoptosis-Resistance of Hypoxic Cells

2003 • 90 citations

Identification of Genes Differentially Induced by Hypoxia in Pancreatic Cancer Cells

2001 • 81 citations

Hypoxia response elements.

1997 • 81 citations

Hdm2 Recruits a Hypoxia-Sensitive Corepressor to Negatively Regulate p53-Dependent Transcription

2003 • 73 citations

Hypoxia response elements

2004 • 45 citations

New antimetastatic hypoxic cell radiosensitizers: design, synthesis, and biological activities of 2-nitroimidazole-acetamide, TX-1877, and its analogues

2001 • 43 citations

Can Gene Therapy Overcome the Problem of Hypoxia in Radiotherapy?

2000 • 28 citations